Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C

Aizawa, Yoshifusa; Y, Shibamoto; Takagi, Ichiro; Zeniya, Mikio; Toda, Gotaro

doi:10.1002/1097-0142(20000701)89:1<53::aid-cncr8>3.0.co;2-6

Cited by 105 publications

(57 citation statements)

References 30 publications

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“…10 They reported in another study that the cumulative probability of HCC development in patients with chronic hepatitis C (excluding cirrhosis) was 4.8% at 5 years (n ϭ 1500), 11 whereas Takano et al reported a probability of approximately 4% (n ϭ 124) in patients with chronic hepatitis C at 5 years, 12 and Aizawa et al reported a probability of approximately 9% (n ϭ 153) at 5 years in patients with chronic HCV or cirrhosis. 13 In the U.S., Hu et al reported that the cumulative probability of HCC development in patients with compensated cirrhosis was 10% at 5 years (n ϭ 112). 14 In France, Serfaty et al reported that the cumulative probability of HCC development in patients with compensated cirrhosis was 11.5% at 4 years (n ϭ 103).…”

Section: Discussionmentioning

confidence: 99%

“…Some multivariate regression studies demonstrated the same outcome as the current study. 13 However, IFN was reported to prevent the development of HCC even in patients in whom the therapy was not effective. 16 Further follow-up studies of IFN-treated patients are essential given that the incidence of HCC in patients with chronic HCV infection increases with its progress over the time of follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

Hamada

Yatsuhashi

Yano

et al. 2002

Cancer

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BACKGROUNDHepatitis C virus (HCV) infection is a heterogeneous disease, the natural history of which remains controversial. There is solid evidence that chronic HCV infection is responsible for the occurrence of hepatocellular carcinoma (HCC). The aim of the current cohort study was to determine the rate of the development of HCC from the time of primary HCV infection and to assess the risk factors for the development of HCC in chronic posttransfusion hepatitis C patients.METHODSFour hundred sixty‐nine patients with clinically compensated HCV, who had undergone a single blood transfusion comprised the current study cohort. Patients with other risk factors for chronic liver disease were excluded. All patients were referred to the liver center at the National Nagasaki Medical Center between December 1980 and December 1998 and were followed prospectively until the end of the analysis (June 2000).RESULTSFollow‐up data were obtained for 445 patients. The mean duration from HCV infection to the end of the observation was 28 years. Fifty‐two patients (11.1%) progressed to HCC. The mean duration from the time of blood transfusion to the diagnosis of HCC was 31 years. Multivariate Cox regression analyses revealed age, fibrosis, duration from HCV infection to study entry, and alcohol consumption to be the independent factors affecting the development of HCC. The risk of developing HCC in patients age ≥ 56 years was increased 7.8‐fold compared with that in patients age < 56 years. The mean age of patients at the time of HCC diagnosis was 65 years (range, 58–79 years).CONCLUSIONSAt the time of diagnosis, 92% of the 52 HCC patients were age > 60 years and 38 of the HCC patients (73%) were in their 60s. There was a significantly negative correlation between the duration from HCV infection to the development of HCC and the age of the patient at the time of infection (correlation coefficient = 0.702; P < 0.0001; Y = 61.1–0.82X), indicating that the age of patients, rather than the duration of HCV infection, is more significant for HCC development in patients with posttransfusion HCV. Moreover, these data may contribute to the design of an optimal follow‐up schedule for patients with posttransfusion HCV. Cancer 2002;95:331–9. © 2002 American Cancer Society.DOI 10.1002/cncr.10662

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

Hamada

Yatsuhashi

Yano

et al. 2002

Cancer

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“…The Italian population-based Dionysos study showed a higher rate of cirrhosis among HCV-positive subjects who drank >30 g/day of alcohol compared to those who drank less, and that all the five patients with HCC among 162 HCV RNApositive subjects examined were alcohol abusers, with a mean alcohol intake of 122 g/day (Bellentani et al, 1999). Other cross-sectional and cohort studies carried out among patients with chronic HCV infection found that alcohol intake favoured the development of cirrhosis and HCC (RoudotThoraval et al, 1997;Ikeda et al, 1998;Aizawa et al, 2000;Harris et al, 2001), and caused the development of HCC at a lower age among alcohol drinkers than non-drinkers (Yotsuyanagi et al, 2004). Reciprocally, studies among alcoholics showed a higher severity of liver disease and a higher risk of HCC in the presence of HCV infection (Mendenhall et al, 1991), and a higher HCC incidence among patients with alcoholic liver cirrhosis with HBsAg or Anti-HCV than those without hepatitis virus infection (Yamanaka et al, 2001).…”

Section: Interaction With Hepatitis C Virusmentioning

confidence: 95%

Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

et al. 2006

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Hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol consumption are major causes of hepatocellular carcinoma (HCC) worldwide. We performed a systematic review of epidemiologic studies carried out on HCC aetiology in Southern Europe, an area with an intermediatehigh prevalence of these agents as well as of putative risk factors such as tobacco smoking, diabetes and obesity. To retrieve the articles, we performed a Medline search for titles and abstracts of articles. After the Medline search, we reviewed the papers and reference lists to identify additional articles. A synergism between HCV infection and HBV infection, overt (hepatitis B virus antigen (HbsAg) positivity) or occult (HBsAg negativity with presence of HBV DNA in liver or serum), is suggested by the results of some studies. The pattern of the risk for HCC due to alcohol intake shows a continuous dose-effect curve without a definite threshold, although most studies found that HCC risk increased only for alcohol consumption above 40-60 g of ethanol per day. Some evidence supports a positive interaction of alcohol intake probably with HCV infection and possibly with HBV infection. A few studies found that coffee has a protective effect on HCC risk due to various risk factors. Some data also support a role of tobacco smoking, diabetes and obesity as single agents or preferably cofactors in causing HCC. In countries with a relatively high alcohol consumption and intermediate levels of HCV and HBV infections (1-3% of population infected by each virus), such as Mediterranean countries, the three main risk factors together account for about 85% of the total HCC cases, leaving little space to other known risk factors, such as haemochromatosis, and to new, still unrecognised, factors as independent causes of HCC.

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“…1 Patients with chronic hepatitis and cirrhosis caused by HBV or HCV are at high risk for HCC. 2 Treatment with IFN-␣ decreases the incidence of HCC in patients with chronic hepatitis C with or without cirrhosis, especially in biologic or virologic responders. [3][4][5][6] Once HCC has developed, possible treatments include surgical resection, transcatheter arterial embolization and radiofrequency, ethanol, and microwave ablation.…”

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confidence: 99%

Inhibition of spontaneous development of liver tumors by inoculation with dendritic cells loaded with hepatocellular carcinoma cells in C3H/HeNCRJ mice

Irie

Homma

Komita

et al. 2004

Intl Journal of Cancer

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Analysis of factors affecting the appearance of hepatocellular carcinoma in patients with chronic hepatitis C

Cited by 105 publications

References 30 publications

Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

Impact of aging on the development of hepatocellular carcinoma in patients with posttransfusion chronic hepatitis C

Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

Inhibition of spontaneous development of liver tumors by inoculation with dendritic cells loaded with hepatocellular carcinoma cells in C3H/HeNCRJ mice

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