This study explored the effects of training computer mouse use in the nondominant hand on clicking performance of the dominant and nondominant hands. Computer mouse use is a daily operation in the workplace and requires minute hand and wrist movements developed and refined through practice and training for many years. Our study had eleven right-handed computer mouse users train their nondominant hand for 15 min a day, five days per week, for six weeks. This study found improved performance with the computer mouse in the dominant hand following nondominant hand training because of the bilateral transfer effect of training. Additionally, our study showed that the nondominant hand is capable of learning the complex movements that our dominant hand has trained for many years. Last, our research showed that nondominant hand performance decreases when the skill is not trained for over a year, but the performance is significantly higher than that prior to the original training and can be rapidly relearned. Overall, training the nondominant hand on the computer mouse will allow for improved performance in industry while allowing safer, sustainable, and more achievable work in a multitude of economies.