Analysis of epidermal fibrous proteins in inflammatory linear verrucous epidermal nevus

Abstract

A baby had inflammatory linear verrucous epidermal nevus (ILVEN). Scale from the lesion was analyzed by sodium lauryl sulfate polyacrylamide gel electrophoresis. It showed a pattern different from psoriatic scale. This procedure was useful in distinguishing the lesion (or ILVEN) from psoriasis, the diagnosis that had been made earlier.

The group of epidermal nevus syndromes

“…They include the presence of one single ventricle 262 or only one coronary ostium, 263 mitral valve defect, 256 septal defect, 264,266 dilated right ventricle, 263 coarctation of the aorta, 256 subaortic stenosis, 256 and Fallot tetralogy. 267 Additional ipsilateral defects comprise an absence of the kidney, 244,268 hydronephrosis and hydroureter, 269 and hypoplasia of lung. 255,264 In exceptional cases, numerous other organs, such as thyroid, adrenal, and ovary are likewise hypoplastic or absent.…”

“…275 Remarkably, dextrocardia has been found in a case of lateralization to the left. 256 In cases of CHILD syndrome, historical misdiagnoses include ILVEN, 251,252,254,267,276 ''epidermal nevus syndrome of Solomon,'' 277 psoriasis, 258,278 ichthyosis, 263,264,266 ''atypical erythrokeratodermia,'' 272 ''large polydystrophic systematized verrucous nevus,'' 250 chondrodysplasia punctata, 253 Conradi syndrome, 276 Olmsted syndrome, 279 and ''verruciform xanthoma.'' [280][281][282][283] Conversely, CHILD syndrome has erroneously been diagnosed in a case of unilateral Conradi-Hünermann-Happle syndrome.…”

The group of epidermal nevus syndromes

“…24,25 Several authors have suggested that some cases of inflammatory linear verrucous epidermal nevus (ILVEN) coexisting with CNS defects may not be coincidental, [26][27][28][29][30][31] but there is so far no convincing evidence for such a nosologic relationship. Most of these patients may have had a CHILD nevus, [32][33][34][35] even in the absence of a detectable NSDHL mutation. Others had, in fact, a noninflammatory EN.…”

Psoríase pustulosa linear X Nevil: relato de caso

“…6 Hence, new attempts have been implemented in the search for diagnostic ellucidation. Adrian and Baden, 11 by means of electrophoretic analysis of epidermal proteins in lauryl-polyacrylamide sulfate gel (SLS-PAGE), demonstrated differences in the electrophoretic patterns of patients with hard-to-diagnose psoriasis. Later on, using this same principle, Bernhard et al 3 demonstrated, in four ILVEN cases, distinct patterns from those found in normal and psoriatic skin.…”