Analysis of endometrial carcinoma in young women at a high-volume cancer center

Biler, Alper; Solmaz, Ulaş; Erkılınç, Selçuk; Gökçü, Mehmet; Bağci, Mustafa; Temel, Orhan; Karadeniz, Tugba; Şancı, Muzaffer

doi:10.1016/j.ijsu.2017.06.083

Cited by 9 publications

(12 citation statements)

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“…Endometrial cancer is mainly a disease that occurs primarily in postmenopausal women, with 75–80% of women being postmenopausal at the time of diagnosis [ 3 , 4 , 5 ]. The incidence of endometrial cancer among premenopausal women varies in the different studies depending on the cut-off age used or evaluation of the ovarian activity [ 6 , 7 , 8 , 9 ]. The average menopausal age for the Malaysian population is around 51 years old [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome

Manap

Phon

et al. 2022

IJERPH

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Endometrial cancer is the sixth most common malignancy in women, and it is known to be a disease among postmenopausal women, but there is rising in the number of endometrial cancers among premenopausal women. This study aims to determine the clinical characteristic, risk factors, outcomes, and survival in pre and postmenopausal women with endometrial cancer in Malaysia. A retrospective study was conducted in Hospital Melaka that involved all women who were diagnosed with endometrial cancer in Hospital Melaka from January 2002 until July 2020. All subjects’ histopathological examination result was confirmed, and their clinical data were extracted and transferred into a standardized data checklist and analysed. A total number of 392 cases was obtained from the Annual Cancer Registry Hospital Melaka. However, only 281 cases were studied, including 44.8% premenopausal and 55.2% postmenopausal women. In the premenopausal group, there were higher incidence of obesity (30.8 + 8.6 vs. 28.9 + 7.1), younger age at menarche (12.7 + 1.5 vs. 13.3 + 1.6), lesser parity (1.47 vs. 3.26), and a higher number of nulliparous women (46.8% vs. 19.4%) as compared to postmenopausal group. The premenopausal group tends to be presented with a well-differentiated grading of tumour (52.4%) and a higher incidence of having concomitant endometrial hyperplasia (41.3%). The mean survival among the premenopausal group (200.3 + 7.9 months) is higher compared to postmenopausal group (153.9 + 6.5 months). These findings correlate with good survival and prognosis among the premenopausal group compared to the postmenopausal group.

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Section: Introductionmentioning

confidence: 99%

“…A tumour with better differentiation has better prognostic value. As the tumour loses its differentiation, the prognostic survival reduces [ 9 , 20 ]. The histologic subtype of the endometrial cell is also a major determinant of the prognosis.…”

Section: Introductionmentioning

confidence: 99%

Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome

Manap

Phon

et al. 2022

IJERPH

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“…Young premenopausal patients under 40 years of age usually have early stage disease and low-grade tumours. 26 Artificially induced menopause and its consequences should be avoided. Therefore, ovarian preservation should be considered in selected cases.…”

Section: Surgical Treatmentmentioning

confidence: 99%

Surgical treatment and fertility perservation in endometrial cancer

Kovačević

2021

Radiology and Oncology

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BackgroundEndometrial cancer (EC) represents a high health burden in Slovenia and worldwide. The incidence is increasing due to lifestyle and behavioural risk factors such as obesity, smoking, oestrogen exposure and aging of the population. In many cases, endometrial cancer is diagnosed at an early stage due to obvious signs and symptoms. The standard treatment is surgery with or without adjuvant therapy, depending on the stage of the disease and the risk of recurrence. However, treatment modalities have changed in the last decades, considerably in the extent of lymphadenectomy.ConclusionsThe gold standard of treatment for is surgery, which may be the only treatment modality in the early stages of low-grade tumours. In recent years, a minimally invasive approach with sentinel node biopsy (SNB) has been proposed. A conservative approach with hormonal treatment is used if fertility preservation is desired. If EC is in advance stage, high-risk histology, or high grade, radiotherapy, chemotherapy, or a combination of both is recommended.

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“…Endometrial cancer is one of the most common malignancies affecting women, with around 9,700 new cases diagnosed in the UK every year (1). Whilst the exact prevalence of endometrial cancer in young women is equivocal, it has been estimated that up to 14% of cases occur in young women aged less than 40 years (2)(3)(4). Risk factors associated with the incidence of endometrial cancer in young women include higher body mass index, nulliparity and polycystic ovarian syndrome (3,5,6).…”

Section: Introductionmentioning

confidence: 99%

Case report: Spontaneous remission of synchronous endometrial and ovarian cancers following pregnancy

et al. 2022

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IntroductionEndometrial cancer is one of the most common malignancies affecting women. It is uncommonly diagnosed in young women, particularly in the absence of abnormal vaginal bleeding symptoms.Case presentationA 28-year-old woman was referred to our department with lower abdominal pain. Transvaginal ultrasound showed a complex right adnexal mass with mixed echogenicity. Magnetic resonance imaging (MRI) identified a right-sided, torted, cystic solid ovarian mass, and a polypoid lesion in the uterine cavity.DiagnosisFollowing multidisciplinary team advice, hysteroscopic transcervical resection of endometrial polypoid mass and laparoscopic right salpingo-oophorectomy was performed. Histopathologic assessment of the endometrial tissue showed changes consistent with grade 1 endometrioid endometrial carcinoma, while the right ovarian mass showed a well-differentiated endometrioid carcinoma.InterventionThe patient underwent hormonal treatment and surveillance whilst making a final decision regarding further surgical management. However, the patient stopped hormonal treatment after 2 weeks, went abroad and absconded from treatment for 8 months. On her return, she had conceived naturally and was in the first trimester of pregnancy. Further management was postponed until the patient was 7 weeks postnatal. The patient was not keen on any further surgical management and opted for close surveillance with ultrasound scans and hysteroscopies with endometrial biopsies. All subsequent endometrial biopsies showed normal endometrium, with no evidence of hyperplasia or malignancy.OutcomeTo date, the patient remains on a 6-monthly surveillance plan and is considered to have had complete natural remission of her endometrial and ovarian cancers following pregnancy.ConclusionThis unique case demonstrates a natural phenomenon, in which the complete, natural remission of endometrial and ovarian cancers occurred following pregnancy and childbirth. The aetiology may be related to the high progesterone levels occurring in pregnancy.

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Analysis of endometrial carcinoma in young women at a high-volume cancer center

Abstract: Our study demonstrated that a cancer antigen 125 level ≥ 35 is the only independent prognostic factor for both progression-free survival and overall survival in patients aged ≤40 years with endometrial cancer.

Cited by 9 publications

References 32 publications

Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome

Endometrial Cancer in Pre-Menopausal Women and Younger: Risk Factors and Outcome

Surgical treatment and fertility perservation in endometrial cancer

Case report: Spontaneous remission of synchronous endometrial and ovarian cancers following pregnancy

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