Abstract:Rationale: Lasalocid (LAS), an ionophore, is used in cattle and poultry farming as feed additive for its antibiotic and growth-promoting properties. Literature on transformation products (TP) resulting from LAS degradation is limited. So far, only hydroxylation is found to occur as the metabolic reaction during the LAS degradation. To investigate potential TPs of LAS, we used electrochemistry (EC) and liver microsome (LM) assays to synthesize TPs, which were identified using liquid chromatography high-resoluti… Show more
“… 167 Knoche et al studied the possible TPs of lasalocid, an antibiotic and growth-promoting feed additive used in cattle and poultry farming. 168 The authors compared EC and a liver microsome assay both followed by LC-MS. The EC was concluded to be time and cost-saving as no costly enzymes or microsomes are needed as well as no incubation time (90 minutes).…”
While the advent of modern analytical technology has allowed scientists to determine the complexity of mixtures, it also spurred the demand to understand these sophisticated mixtures better. Chemical transformation can...
“… 167 Knoche et al studied the possible TPs of lasalocid, an antibiotic and growth-promoting feed additive used in cattle and poultry farming. 168 The authors compared EC and a liver microsome assay both followed by LC-MS. The EC was concluded to be time and cost-saving as no costly enzymes or microsomes are needed as well as no incubation time (90 minutes).…”
While the advent of modern analytical technology has allowed scientists to determine the complexity of mixtures, it also spurred the demand to understand these sophisticated mixtures better. Chemical transformation can...
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