Analysis of E‐Selectin S128R gene polymorphism in pancreatic cancer

Panoussopoulos, George S.; Theodoropoulos, George; Michalopoulos, Nikolaos V.; Gazouli, Maria; Flessas, John; Taka, Stela; Stamopoulos, Paraskevas; Manouras, Andreas; Zografos, George

doi:10.1002/jso.21648

Cited by 9 publications

(14 citation statements)

References 30 publications

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“…Although the association wasnotstatisticallysupportedforthegenotypes,wefounda higherrepresentationoftheSer/ArgandArg/Arggenotypes inbreastcancerpatientscomparedwiththehealthyindividuals, which is in agreement with other studies on pancreatic [20]andcolorectal [18,19]cancer.Sincethisistheonlypaper thatevaluatestheE-selectinpolymorphisminbreastcancer, we compared the allelic and genotypic distribution of our healthycontrolswiththoserecruitedforpancreatic [20]and colorectalcancer [18,19]studies.AmongtheFrenchhealthy subjects, Hebbar et al [19] noted that the Ser/Ser genotype waspresentin85.5%,theArgallelegenotype(Ser/Arg+Arg/ Arg)in14.5%,andtheArgallelein7.9%oftheindividuals. Alessandroetal.…”

Section: Discussionsupporting

confidence: 90%

“…[18]reportedthat90%ofCaucasianswere Ser/Ser homozygotes, 10% were carriers of the Arg allele genotype,and5%werecarriersoftheArgallele.Inanother study,Panoussopoulosetal. [20]foundthat63.75and36.25% of the Greek healthy subjects were carriers of Ser/Ser and Argallelegenotypes,respectively,and22.8%werecarriersof…”

Section: Discussionmentioning

confidence: 98%

“…A common single nucleotide polymorphism (SNP) has been detected in exon 4 of the E-selectin gene resulting an amino acid substitution of serine (Ser) for arginine (Arg) at position128withintheextracellulardomainofthereceptor, whichincreasesitsaffinityforligandssuggestingitsroleasa functionalpolymorphism.Earlierstudieshaveshownthatthe Ser128Argvariantincreasestheadhesionoflymphocytesand myeloidcellstoendothelialcells [15,16].Furthermore,endothelial cells harboring the variant support significantly more rolling and adhesion of neutrophils and mononuclear cells [17]comparedwithendothelialcellshavingthewild-typeEselectin.TodatetheroleoftheSer128Argpolymorphismof E-selectinhasbeeninvestigatedincolon [18,19]andpancreatic [20] cancers, but no information is available on breast cancer. Recently, studies on colorectal cancer have shown thatindividualswhowerecarriersofthepolymorphismhave agreaterriskofdevelopingthediseaseaswellasanincreased susceptibility to develop metastases [18,19].…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Recently, studies on colorectal cancer have shown thatindividualswhowerecarriersofthepolymorphismhave agreaterriskofdevelopingthediseaseaswellasanincreased susceptibility to develop metastases [18,19]. The polymorphismwasalsofoundtoincreasetheriskofpancreaticcancer butnoaffectwasseenforthedevelopmentofmetastases [20]. Studies on colon cancer cells revealed that the tumor cells carryingtheArgvariantmayfacilitatetheadhesionofcirculatingtumorcellstotheendotheliumatdistantsitesleading toahigherriskofmetastaticseeding [18].…”

Section: Immunohistochemistrymentioning

confidence: 99%

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Polymorphic Variant Ser128Arg of E-Selectin is Associated with Breast Cancer Risk and High Grade Tumors

2011

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Background: The present study aimed to evaluate the association between the E-Selectin Ser128Arg polymorphism and breast cancer risk and clinicopathological characteristics of the patients. Materials and Methods: The genotypes of 387 breast cancer patients and 252 healthy women who had no history of any malignancy were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in a hospital-based Malaysian population. Results: The frequency of the Arg allele was significantly (p = 0.030) higher in breast cancer patients than in healthy individuals. Women who were Ser/Arg heterozygotes (adjusted odds ratio (OR^adj) = 1.607; 95% confidence interval (CI) = 1.008–2.564), and carriers of the Arg allele genotype (OR^adj = 1.587; 95% CI = 1.037–2.430) or Arg allele (OR^adj = 1.509; 95% CI = 1.040–2.189) showed a significantly increased risk of breast cancer. Patients who were carriers of the Arg allele genotype showed a significant association with poorly differentiated tumors (p = 0.002). Conclusion: The Ser128Arg polymorphism might confer an increased susceptibility to breast cancer and contribute to aggressive phenotypic characteristics.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Immunohistochemistrymentioning

confidence: 99%

Section: Immunohistochemistrymentioning

confidence: 99%

See 2 more Smart Citations

Polymorphic Variant Ser128Arg of E-Selectin is Associated with Breast Cancer Risk and High Grade Tumors

2011

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“…Of these, 150 publications were excluded because of case reports, or reviews, or non-relevance research, or duplicate data, or incomplete date. Finally, eight studies were included in this metaanalysis, with a total of 1,675 cancer cases and 2,285 controls (Alessandro et al, 2007;Bai, 2009;Hebbar et al, 2009;Panoussopoulos et al, 2010;Naidu et al, 2011;Xia et al, 2012;Kontogianni et al, 2013;Liarmakopoulos et al, 2013). A flow diagram schematized the process of selecting and excluding articles with specific reasons was shown in Figure 1, and the main characteristics of eligible studies were shown in Table 1.…”

Section: Studies Selection and Characteristicsmentioning

confidence: 99%

E-Selectin S128R Polymorphism is Associated with Cancer Risk: a Meta-analysis

Cheng

Hao²,

Zhou³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Genetic factors have been shown to play an important role in the development of cancers. However, individual studies may fail to completely demonstrate complicated genetic relationships because of small sample size. Therefore, we performed a meta-analysis to evaluate the association of E-selectin Ser128Arg (S128R) with cancer risk. Materials and Methods: A literature search in PubMed, Embase, Web of Science, Science Direct, SpringerLink, EBSCO, Wanfang, and Chinese National Knowledge Infrastructure databases was carried out to identify studies of the association between E-selectin S128R polymorphism and cancer risk. The odds ratio (OR) with 95% confidence intervals (95%CIs) were used to assess the strength of association. Results: A total of eight studies involving 1,675 cancer cases and 2,285 controls were included in the meta-analysis. In overall populations, S128R polymorphism seemed to be associated with cancer risk (Arg allele vs Ser allele: OR=1.65, 95%CI =1.33-2.04, p<0.01; Arg/Arg+Arg/Ser vs Ser/Ser: OR=1.87, 95%CI =1.48-2.36, p<0.01; Arg/Ser vs Ser/Ser: OR=1.80, 95%CI =1.51-2.14, p<0.01). Similarly, subgroup analysis by ethnicity and source of control also revealed that this polymorphism was related to cancer risk. Conclusions: Our meta-analysis revealed that there was association between the E-selectin S128R polymorphism and the risk of cancer. Further large and well-designed studies are needed to confirm this association.

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E‐selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population

Xia

et al. 2011

Molecular Carcinogenesis

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Host immune responses are critical steps for carcinogenesis. Single nucleotide polymorphisms (SNPs) in immunoregulatory genes may influence gastric cancer risk. We performed a genotyping analysis for immunoregulatory genes in 311 gastric cancer cases and 425 controls from a Chinese population. We found that there were significant differences of E-selectin variant rs5361 (A>C) and FCGR2A variant rs1801274 (T>C) between cases and controls (P = 0.022 and P = 0.0001, respectively). Logistic regression analysis indicated that genotype of E-selectin rs5361AC increased the risk of gastric cancer significantly (P = 0.026, adjusted Odds ratio (OR) = 2.84, 95% confidence interval (CI) = 1.13-7.12). C allele of E-selectin rs5361 showed a significant increased frequency in cases (P = 0.023). However, the E-selectin variant did not affect the protein expression. E-selectin protein was observed not only in tumor interstitial vascular endothelial cells, but also in gastric cancer cells at primary and metastatic sites. The protein was associated with clinicopathological characteristics of gastric cancer, such as age (P = 0.008), tumor size (P = 0.027), differentiation (P = 0.000), and tumor-node-metastasis (TNM) stage (P = 0.006). CT and CC + CT genotypes of FCGR2A variant rs1801274 increased gastric cancer risk (P = 0.000, adjusted OR = 1.92, 95%CI = 1.36-2.72; P = 0.003, adjusted OR = 1.68, 95%CI = 1.20-2.35, respectively). Interleukin-4 receptor (IL-4R) variant rs2107356 presented negative correlations to E-selectin variant rs5361 and FCGR2A variant rs1801274 (P = 0.035 and P = 0.023) in conferring susceptibility to gastric cancer. We concluded E-selectin variant rs5361 and FCGR2A variant rs1801274 were significantly associated with gastric cancer risk. Expression of E-selectin protein would promote progression of gastric cancer.

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Analysis of E‐Selectin S128R gene polymorphism in pancreatic cancer

Abstract: E-selectin S128R "C" allele may confer an increased susceptibility to pancreatic cancer development, while its carriage status does not appear to be related to the aggressive features of this malignancy.

Cited by 9 publications

References 30 publications

Polymorphic Variant Ser128Arg of E-Selectin is Associated with Breast Cancer Risk and High Grade Tumors

Polymorphic Variant Ser128Arg of E-Selectin is Associated with Breast Cancer Risk and High Grade Tumors

E-Selectin S128R Polymorphism is Associated with Cancer Risk: a Meta-analysis

E‐selectin rs5361 and FCGR2A rs1801274 variants were associated with increased risk of gastric cancer in a Chinese population

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