This work selected a PV power station located in the low latitude and high altitude plateau area of Sichuan, China, as the research object. The environment, climate, operation and maintenance status of the PV power station were investigated and the dust on PV panels was collected to measure its properties to analyse the source and composition of the dust. The results showed that the main component of the dust was SiO2 and the dust particles were relatively uniform in size and regular in shape but not uniform spherical particles. Meanwhile, EDEM-FLUENT simulation soft wares were employed to simulate the accumulation process of dust on the surface of PV panels at different wind speeds under the installation inclination of 25 degrees and 35 degrees, respectively. Furthermore, systematically analysing the force between the dust and PV panels, exploring the action modes of various forces and sorting out the dominant force were carried out for the establishment of a mechanical model for dust accumulation or dust removal. The force of dust in this PV power station mainly included gravity 10−9~10−8N, van der Waals force 10−9N, electrostatic force 10−9~10−11N and fluid force. Meanwhile, the larger particles almost accumulated in the front row of PV modules while the smaller particles can float farther with the wind. Finally, combined with the mechanical model of dust on the PV panel’s surface, dust’s adhesion process and accumulation mechanism were explained.