Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report

Abstract

Background: The human leucocyte antigen (HLA) system plays an important role in the modulation of the immune response. An association between HLA and pulmonary tuberculosis (TB) has been examined in several populations but the results have been inconsistent. The aim of this study was to evaluate the correlation of DQB1 alleles with TB patients and healthy controls in the same ethnic group in Poland. Method: The DQB1 alleles of 38 patients with TB and 58 healthy university staff volunteers were determined by a PCR-SSP low resolution method. Results: The DQB1*05 allele occurred more frequently (p adjusted for multiple comparison = 0.002, OR = 2.84, 95% CI 1.57 to 5.15) and the DQB1*02 allele occurred less frequently (p = 0.01, OR = 0.39, 95% CI 0.21 to 0.71) in patients with TB than in controls. The occurrence of DQB1*03,*04,*06 alleles was similar in the two populations. Conclusions: The occurrence of specific DQB1 alleles may be linked to susceptibility/resistance to tuberculosis.

Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis

“…Alleles HLA-A*31 and HLA-B*55, with higher frequencies in the patients group, may also contribute to an impaired humoral response and thus be involved in susceptibility to leptospirosis, as they were associated with IgG subgroup deficiency (IgGSD) in a North American cohort [22]. Some HLA alleles outside the 8.1 haplotype with increased frequencies in the patient group have been associated with other infections, namely, HIV (HLA-B*55, HLA-B*58, and HLA-Cw*04 have a positive association with disease progression) [23], HBV (HLA-DRB1*13 appears to be protective) [24], HCV (HLA-Cw*04 is related to the persistence of the infection) [25], tuberculosis (HLA-DQB1*05 confers susceptibility) [26], dengue hemorrhagic fever (HLA-A*31 relates to susceptibility and HLA-DRB1*04 to protection) [27,28], and human papillomavirus (HPV; HLA-DRB1*04, HLA-DRB1*13, and HLA-DQB1*05 appear to provide some protection) [29,30]. The influence of HLA class I polymorphisms in the susceptibility to leptospirosis is probably related to alterations in the affinity of the HLA molecule binding site to the leptospiral antigens.…”

HLA and disease

“…Poland [82] DQB1*05 *These are some of the representative population studies from various continents. Heterodimer DQA1*0501-DQB1*0201/02 Dutch [65] DQ2 Homozygotes, DQA1*05-DQB1*02/DQA1*0201-DQB1*02 heterozygotes France [66] HLA-DQ2 (DQA1*0501/DQB1*0201) and DR53 Italy [67] HLA-DQ2 Netherlands [68] HLA-DQ2.5/2.5 homozygotes, HLA-DQ2.5/2.2 heterozygotes Norway [69] HLA-DQ2 (DQA 1*0501, DQB 1*0201) Spain [70] HLA-DRB1*04 (DR4) *These are some of the representative population studies from various continents.…”

Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia

“…Several studies have supported a weak to moderate association of HLA with TB; the implicated antigens include HLA-DR2, encoded by HLA-DR*15 and HLA-DR*16 alleles in Indians, Indonesians, and Poles [9 -13], -DR13 in Poles [14], -DR14 in Iranians [15], HLA-DQB1 in Cambodians and Poles [16,17], and HLA-DQw1 in Indonesians [10]. However, other studies have reported no such associations [18 -20].…”