Analysis of DNA ploidy and expression of tumour-associated antigens on human oral carcinomas xenografted in nude mice

The site-dependent growth characteristics of a human xenotransplanted basaloid squamous cell carcinoma

“…Unfortunately the lack of suitable biological models has restricted progress in the elucidation of the cellular and molecular mechanism implicated in the malignant progression of oral carcinoma (Damodaran et al 1997).…”

“…in the histogenetically equivalent organ, because it is possible that some of the malignant phenotypes, such as invasive growth, can only be expressed if the tumour grows in the original organ environment (Giavazzi et al 1986;Gutman and Fidler 1995). Recently it has been reported that, among 12 transplanted human oral carcinomas, 7 ± with poor to moderate dierentiation state ± were accepted as xenografts (Damodaran et al 1997). These xenografted oral carcinomas re¯ected many of the characteristic features of the primary tumour from which they were derived; nevertheless, some showed increased dierentiation of the tumour with excessive keratinisation.…”