Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction

Fauzi, Muhammad Al Rizqi Dharma; Hendradi, Esti; Pudjiastuti, Pratiwi; Widodo, Riyanto Teguh

doi:10.22146/ijc.55047

Cited by 5 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevated levels of ash content can render the capsule shell more brittle and prone to breakage. Additionally, ash content has implications for the disintegration time of the capsule shell, as it can serve as a barrier to water penetration, potentially slowing down the disintegration process [15].…”

Section: Ash Contentmentioning

confidence: 99%

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Soraya,

Putri,

Purwoto

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

Recently, seaweed-based capsule shells have become more popular because of their reliable quality and animal-free source. But these shells’ prolonged disintegration times are a common problem. This research aims to look for formulations with disintegrant substitution or a combination of several disintegrants to obtain capsule shells that disintegrate quickly. Several studies have explored the incorporation of additional disintegrants such as Polyvinylpyrrolidone (PVP) K-30, Sodium starch glycolate (primogel), Croscarmellose sodium (SSC), and Sodium carboxymethylcellulose (Na-CMC) to address this challenge. The study investigates various combinations of disintegrants in the formulation of capsule shells to achieve rapid disintegration time. The variation in composition of disintegrants was determined using Simplex Lattice Design (SLD) in Design Expert® 13.0.12. Balancing the desirable characteristics of quick disintegration with other factors posed a significant challenge. All types of disintegrants exerted a notable influence on the response variables. To achieve a substantial reduction in disintegration time, the utilization of primogel is strongly recommended. However, it should be noted that primogel contains minerals that do not disintegrate, resulting in an elevated ash content. In contrast, PVP K-30 demonstrates promising performance but falls slightly short of primogel’s efficacy in accelerating disintegration. Additionally, PVP K-30 exhibits a marked advantage in minimizing ash content within the capsule shell. Optimization results indicate that a combination of PVP K-30 and primogel yields a capsule shell with the fastest disintegration time, approximately 23.908 minutes, while maintaining a minimal ash content of 10.487%.

show abstract

Section: Ash Contentmentioning

confidence: 99%

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Soraya,

Putri,

Purwoto

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…In this analysis, the zero-order release kinetic model is used to determine the relationship between the release time and percentage of microcapsules. The zero-order kinetic model is effectively considered for the sustained released samples [23][24].…”

Section: ■ Introductionmentioning

confidence: 99%

Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts Using Alginate: Preparation, Biological Activities, and Release

et al. 2023

View full text Add to dashboard Cite

The bioactive compounds naturally present in plants have great importance due to their biological characteristics. These substances could lose their active characteristics since they are highly unstable. Microencapsulation is one of the techniques to improve stability and protect these compounds. In this work, Ruellia tuberosa L. ethanolic extracts microcapsules were prepared using a freeze-drying method by varying pH, alginate concentration, and stirring time. The encapsulation efficiency (EE), characteristics, alpha-amylase inhibition activity, and release behavior of the microcapsules were investigated. The results highlighted that the highest encapsulation efficiency for the microcapsules was obtained at pH 6, alginate concentration of 1% (w/v), and 30 min of stirring time (51.63% EE). The microcapsules mostly had spherical shapes with a mean diameter of 197.53 μm. The alpha-amylase inhibition assay from microcapsules resulted in the IC50 value of 46.66 ± 0.13 μg/mL, demonstrating high biological activity. The bioactive substances from microcapsules were released during intervals of 30–120 min at pH values of 1.2 and 7.4. Only 3.51% of the bioactive substances were released at pH 1.2 after 120 min, compared to 55.78% at pH 7.4. Overall, this work confirms the possibility of developing plant extracts with preserved biological activity using the produced microcapsules.

show abstract

“…Radioactive mineral, especially uranium, can be used as a core element of nuclear fuel [8]. Other radioactive element such as thorium is also considered as potential fuel that could complement uranium.…”

Section: Introduction mentioning

confidence: 99%

Uncovering the Distribution Zones of Uranium and Thorium in Bangka Island

Ngadenin,

Fauzi,

Syaeful

et al. 2023

Atom Indo.

View full text Add to dashboard Cite

Radioactive minerals, especially containing uranium and thorium, can be used as a core element of nuclear fuel. Bangka Island is located in The Southeast Asian Tin Belt where it has a large uranium and thorium potential. The purpose of this study is to delineate distribution zone of uranium and thorium in Bangka Island. The study methods consist of radiometric measurement and mapping, petrographic analysis, and mineralogical analysis of pan concentrate samples. Based on radiometric measurement, positive anomaly value of equivalent uranium (eU) is ranging from 5-15 ppm while of equivalent thorium (eTh) is ranging from 45-75 ppm. The result of petrographic analysis from several outcrops of Klabat Granite indicated that there are monazites found in several samples of Mangkol Granite and of Bebuluh Granite. Radioactive mineral indication also can be identified as pleochroic halo within biotite in samples of Pelangas Granite and Menumbing Granite. Based on the result of mineralogical analysis of pan concentrate samples, it was identified that monazites can be found in all samples. Monazites constitute the percentages ranging from 2.82-10.66 %. Zircon also can be identified with percentages ranging from 9.13-76.75 % while ilmenite and magnetite minerals have average percentages of 24.09 % and 5.97 %, respectively. Favorable zones can be delineated in outcrops of Klabat Granite, Ranggam Formation and alluvial deposits in northern, northwestern, northeastern, central, and southeastern parts of Bangka Island. The occurrences of monazites in those lithological units are the main factors of high radioactivity in Bangka Island. Based on petrographic and mineralogical composition, those granite bodies which are correlated with Klabat Granite are mostly associated with ilmenite series with S-Type granitic rocks.

show abstract

Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction

Cited by 5 publications

References 17 publications

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Enhancing carrageenan-based capsule shell formulation from kappaphycus striatum for accelerated disintegration time with multiple disintegrant

Microencapsulation of <i>Ruellia tuberosa</i> L. Extracts Using Alginate: Preparation, Biological Activities, and Release

Uncovering the Distribution Zones of Uranium and Thorium in Bangka Island

Contact Info

Product

Resources

About