Analysis of Direct Renal Actions of Alpha and Beta Adrenergic Stimulation Upon Sodium Excretion Compared to Acetylcholine

Pearson, James E.; Williams, Ronald L.

doi:10.1111/j.1476-5381.1968.tb00984.x

Cited by 20 publications

(12 citation statements)

References 29 publications

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“…This efficient renal inactivation of the drug allowed us to examine the direct effect of intrarenal beta adrenergic stimulation on water diuresis in the absence of concomitant alterations in systemic hemodynamics. While previous investigators have infused isoproterenol into the renal artery (22,23,28), in none of these studies have the systemic effects of the drug been adequately evaluated. In some of these studies arterial pressure has been shown to decrease (22,23) while in other studies the arterial pressure has been unchanged during the intravenous administration of isoproterenol (28).…”

Section: Introductionmentioning

confidence: 99%

“…While previous investigators have infused isoproterenol into the renal artery (22,23,28), in none of these studies have the systemic effects of the drug been adequately evaluated. In some of these studies arterial pressure has been shown to decrease (22,23) while in other studies the arterial pressure has been unchanged during the intravenous administration of isoproterenol (28). However, as demonstrated in the present study, arterial pressure may remain constant in the presence of substantial systemic effects of beta adrenergic stimulation to increase cardiac output and to decrease total peripheral resistance.…”

Section: Introductionmentioning

confidence: 99%

“…3, Table I). We can not exclude, however, the possibility that the fall in systemic arterial pressure during intravenous isoproterenol was associated with a baroreceptormediated increase in renal sympathetic tone which was obscured by the direct renal-vasodilating effect of the drug (22,23). If present, such an effect of increased renal sympathetic tone would have to be mediated by circulating catecholamines in the denervated kidneys.…”

Section: Introductionmentioning

confidence: 99%

“…The results also excluded a major role of alterations in renal hemodynamics and renal sympathetic tone in this antidiuretic response. Moreover, no experimental evidence was obtained to support a direct effect of beta [20][21][22][23][24][25][26][27][28][29][30] kg. In these animals food was withheld 18 hr before study, but water was allowed ad lib.…”

Section: Introductionmentioning

confidence: 99%

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Mechanism of Antidiuretic Effect of Beta Adrenergic Stimulation

Schrier¹,

Lieberman²,

Ufferman³

et al. 1972

J. Clin. Invest.

114

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A B S T R A C T The effect of beta adrenergic stimulation on renal-diluting capacity was examined in the dog. Beta adrenergic stimulation with intravenous isoproterenol significantly increased urinary osmolality (Uo.m) and decreased free water clearance (CH:}O), and these effects were rapidly reversible with cessation of the infusion. This antidiuretic effect of systemic beta adrenergic stimulation was comparable in innervated and denervated kidneys and was not associated with alterations in glomerular filtration rate or renal vascular resistance. Renal perfusion pressure was maintained constant in all of the experiments. The same dose of isoproterenol, which produced the antidiuretic effect and markedly stimulated cardiac beta adrenergic receptors when infused intravenously, was not found either to increase Uosm or to decrease CH2O when infused directly into the renal artery. Removal of the source of production and release of antidiuretic hormone (ADH) was, however, found to abolish the effect of intravenous isoproterenol on Uoar. A small effect on CH20 persisted and appeared to be related to an increase in arterial hematocrit. Thus, the results of the study exclude a major role of alterations in renal hemodynamics and renal innervation in the antidiuretic response to betaadrenergic stimulation with isoproterenol. They also provide no support for the hypothesis that beta adrenergic stimulation may directly alter the water permeability of the renal tubular epithelium. Rather the results suggest that the primary mechanism of the antidiuretic effect of beta adrenergic stimulation involves the integrity of the hypothalamoneurohypophyial system and the release of ADH.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mechanism of Antidiuretic Effect of Beta Adrenergic Stimulation

Schrier¹,

Lieberman²,

Ufferman³

et al. 1972

J. Clin. Invest.

114

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show abstract

“…In another study, a brief infusion of isoproterenol into a renal artery of a saline-loaded dog increased renal blood flow and sodium excretion (UNaV) ipsilaterally but did not appear to alter glomerular filtration rate (GFR) (4 (6).…”

Section: Introductionmentioning

confidence: 99%

Depression of proximal tubular sodium reabsorption in the dog in response to renal beta adrenergic stimulation by isoproterenol

Gill¹,

Casper²

1971

J. Clin. Invest.

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A B S T R A C T Water diuresis was produced in anesthetized hypophysectomized, cortisone-treated dogs by infusion of 2.5% dextrose. Alpha adrenergic blockade of the left kidney produced by infusion of phenoxybenzamine in the left renal artery was associated with a significantly (P < 0.05) greater rate of urine flow (V) and free water excretion (CH2o) in the left kidney than in the right despite similar glomerular filtration rates (GFR) (17 ±1.3 ml/min, left; 18 ±0.9 ml/min, right). Sodium excretion (UNaV) was similar in the two kidneys (3 and 5 iEq/min).When beta adrenergic stimulation of the left kidney was superimposed on alpha blockade by the addition of isoproterenol to the left renal artery infusate, GFR remained unchanged and similar in the two kidneys, as V and CH20 increased significantly (P < 0.01) in the left kidney but not in the right. When isoproterenol was discontinued, V and CH2o returned towards control in the left kidney and remained unchanged in the right. The ratios of the left kidney to the right during control, isoproterenol, and postcontrol were 1.22, 1.65, and 1.35, respectively, for V and 1.36, 1.90, and 1.44, respectively, for CH20. Sodium excretion remained unchanged and similar in the two kidneys throughout the study.The results indicate that blockade of alpha adrenergic activity inhibits the increased proximal tubular sodium reabsorption which anesthesia induces in the dog.Beta adrenergic stimulation appears to decrease proximal tubular sodium reabsorption but does not prevent virtually complete reabsorption of the increased quantity of delivered sodium by the ascending limb of the loop of Henle and the distal tubule. These changes in sodium reabsorption presumably are not associated with changes in colloid osmotic pressure or hydrostatic pressure in the peritubular capillary inasmuch as cortical and noncortical plasma flow, filtration fraction, and mean arterial pressure in the left kidney were unchanged. Thus, isoproterenol probably produced its effects through a direct action on the renal tubule, possibly through the mediation of the adenyl cyclase system.

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Neural Control of Renal Function

Moss

Colindres

Gottschalk

1992

Comprehensive Physiology

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The sections in this article are: Current Research Historical Perspective Neuroanatomy and Neurophysiology Efferent Renal Innervation Afferent Renal Innervation Renal Adrenergic Receptors General Concepts Prejunctional Renal Receptors Post‐ and Extrajunctional Adrenoceptors Renal Tubular and Vascular Dopamine Receptors Renal Cholinergic Receptors Cellular Transduction of Neurotransmitter Effects Sympathetic Nervous System and Renal Hemodynamics Vasoconstrictor Responses Vasodilatory Responses Sympathetic Nervous System and Renal Tubular Function Studies in Anesthetized Animals Studies in Conscious Animals Effects of Neurotransmitters on Renal Tubular Function Cellular Mechanisms in the Renal Tubular Responses to Catecholamines Sympathetic Nervous System and Renin Secretion by the Kidney General Concepts Effects of Direct and Reflex Stimulation of the Renal Nerves Effects of Renal Denervation on Renin Release Renal Adrenoceptors Involved in Renin Secretion Interactions Between Nerves and Prostaglandins in Renin Release

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Analysis of Direct Renal Actions of Alpha and Beta Adrenergic Stimulation Upon Sodium Excretion Compared to Acetylcholine

Cited by 20 publications

References 29 publications

Mechanism of Antidiuretic Effect of Beta Adrenergic Stimulation

Mechanism of Antidiuretic Effect of Beta Adrenergic Stimulation

Depression of proximal tubular sodium reabsorption in the dog in response to renal beta adrenergic stimulation by isoproterenol

Neural Control of Renal Function

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