Analysis of Different Activation Statuses of Human Mammary Epithelial Cells from Young and Old Groups

Abstract

Human mammary epithelial cells have different proliferative statuses and demonstrate a close relationship with age and cell proliferation. Research on this topic could help understand the occurrence, progression and prognosis of breast cancer. In this article, using significance analysis of a microarray algorithm, we analyzed gene expression profiles of human mammary epithelial cells of different proliferative statuses and different age groups. The results showed there were significant differences in gene expression in the same proliferation status between elderly and young groups. Three common differentially expressed genes were found to dynamically change with the proliferation status and to be closely related to tumorigenesis. We also found elderly group had less status-related differential genes from actively proliferating status to intermediate status and more statusrelated differential genes from intermediate status than the young group. Finally, functional enrichment analyses allowed evaluation of the detailed roles of these differentially-expressed genes in tumor progression.

Breast Cancer Screening Barriers from the Womans Perspective: a Meta-synthesis

“…Regarding the results of the current study, the most important barriers besides the barriers already discussed are: procrastination, embarrassment, long wait for getting an appointment, language barriers, and previous negative experiences that are indicated in various studies (Feng et al, 2014;Floriano et al, 2014). To surmount these barriers we recommend: identification of high risk women and their follow-up to prevent procrastination, providing private service places and appropriate time for service provision to solve the embarrassment problem, management of health service providers having the same language with people, providing the women with translators or teaching the native languages to the service providers to eliminate the language barriers, and presentation of good quality services and appropriate behavior with the patients to prevent negative screening experiences.…”