Analysis of degradation and pathways of three common antihistamine drugs by NaClO, UV, and UV-NaClO methods

Liu, Anchen; Lin, Wenting; Ping, Senwen; Guan, Wenqi; Hu, Ningyi; Zheng, Sichun; Ren, Yuan

doi:10.1007/s11356-022-18760-8

Cited by 11 publications

(3 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has often been detected as an aqueous pollutant, indicating high stability in the environment [ 42 ]. Chemical oxidation methods were tested for cetirizine removal using sodium hypochlorite with a low degradation effect and UV-catalyzed oxidation resulting in high degradation efficiency [ 43 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

Application of Raney Al-Ni Alloy for Simple Hydrodehalogenation of Diclofenac and Other Halogenated Biocidal Contaminants in Alkaline Aqueous Solution under Ambient Conditions

et al. 2022

View full text Add to dashboard Cite

Raney Al-Ni contains 62% of Ni2Al3 and 38% NiAl3 crystalline phases. Its applicability has been studied within an effective hydrodehalogenation of hardly biodegradable anti-inflammatory drug diclofenac in model aqueous concentrates and, subsequently, even in real hospital wastewater with the aim of transforming them into easily biodegradable products. In model aqueous solution, complete hydrodechlorination of 2 mM aqueous diclofenac solution (0.59 g L−1) yielding the 2-anilinophenylacetate was achieved in less than 50 min at room temperature and ambient pressure using only 9.7 g L−1 of KOH and 1.65 g L−1 of Raney Al-Ni alloy. The dissolving of Al during the hydrodehalogenation process is accompanied by complete consumption of NiAl3 crystalline phase and partial depletion of Ni2Al3. A comparison of the hydrodehalogenation ability of a mixture of diclofenac and other widely used halogenated aromatic or heterocyclic biocides in model aqueous solution using Al-Ni was performed to verify the high hydrodehalogenation activity for each of the used halogenated contaminants. Remarkably, the robustness of Al-Ni-based hydrodehalogenation was demonstrated even for the removal of non-biodegradable diclofenac in real hospital wastewater with high chloride and nitrate content. After removal of the insoluble part of the Al-Ni for subsequent hydrometallurgical recycling, the low quantity of residual Ni was removed together with insoluble Al(OH)3 obtained after neutralization of aqueous filtrate by filtration.

show abstract

Section: Resultsmentioning

confidence: 99%

Application of Raney Al-Ni Alloy for Simple Hydrodehalogenation of Diclofenac and Other Halogenated Biocidal Contaminants in Alkaline Aqueous Solution under Ambient Conditions

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Approximately 22% of the global population experiences allergic reactions, 48 and a majority of them rely on antihistamines for relief (e.g., over 50% of people with allergies in USA). 49 Antihistamines are readily accessible as over-the-counter pharmaceuticals, and their global consumption rates have been increasing.…”

Section: Resultsmentioning

confidence: 99%

Pharmaceutical Residues in Edible Oysters along the Coasts of the East and South China Seas and Associated Health Risks to Humans and Wildlife

Wu,

Sin,

Cai

et al. 2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

The investigation of pharmaceuticals as emerging contaminants in marine biota has been insufficient. In this study, we examined the presence of 51 pharmaceuticals in edible oysters along the coasts of the East and South China Seas. Only nine pharmaceuticals were detected. The mean concentrations of all measured pharmaceuticals in oysters per site ranged from 0.804 to 15.1 ng g −1 of dry weight, with antihistamines being the most common. Brompheniramine and promethazine were identified in biota samples for the first time. Although no significant health risks to humans were identified through consumption of oysters, 100− 1000 times higher health risks were observed for wildlife like water birds, seasnails, and starfishes. Specifically, sea snails that primarily feed on oysters were found to be at risk of exposure to ciprofloxacin, brompheniramine, and promethazine. These high risks could be attributed to the monotonous diet habits and relatively limited food sources of these organisms. Furthermore, taking chirality into consideration, chlorpheniramine in the oysters was enriched by the S-enantiomer, with a relative potency 1.1−1.3 times higher when chlorpheniramine was considered as a racemate. Overall, this study highlights the prevalence of antihistamines in seafood and underscores the importance of studying enantioselectivities of pharmaceuticals in health risk assessments.

show abstract

“…Although no significant correlation (p > 0.05) could be found for all of the OMPs degradation with either of the photochemical properties or major functional groups, the OMPs could be degraded through the following major photodegradation routes suggested by Among the 75 OMPs evaluated in this study, information on degradation pathways is available for meclofenamic acid (photocyclisation), norfloxacin (photodehalogenation), , diclofenac (decarboxyllation), atenelol (hydroxylation) (Salgado et al, 2013), sulphamethoxazole (desulphonamidation, photoelimination, hydroxylation), amitryptiline (photohydration) (Nassar et al, 2017), tamoxifen (hydroxylation) (Ferrando-Climent et al, 2017), sertraline (dechlorination and dehydration) (Calza et al, 2021), salicyclic acid (hydroxylation) , rantidine (denitration) , oxazepam (hydroxylation) (Kosjek et al, 2012), diazepam (hydroxylation and demethylation) (Mitsika et al, 2021), cetirizine (dechlorination and dehydroxylation) and fexofenadine (deamination and dehydroxylation) (Liu et al, 2022). Additionally, Lin et al (2022) reported transformation pathways for antidepressants including citalopram, fluoxetine, sertraline and venlafaxine.…”

Section: Discussionmentioning

confidence: 99%

UV-based advanced oxidation process for nutrient stabilisation and organic micropollutant degradation in source-separated human urine

Demissie

2023

View full text Add to dashboard Cite

Urine dehydration is one of the technological approach to recover nutrients in concentrated form from source separated urine. When drying fresh urine, nitrogen loss occurs due to hydrolysis of urea into ammonia unless methods to inactivate urease enzyme are employed. In addition, concerns arise when using urine-derived fertiliser due to the potential presence of organic micropollutants (pharmaceuticals). This thesis evaluated ultraviolet (UV) treatment as an alternative chemical-free nutrient stabilisation (urease inactivation) and organic micropollutant (OMP) degradation technology. Urease inactivation and OMP degradation in water and in urine (synthetic urine, real urine from human subjects) were studied in a photoreactor equipped with a low-pressure mercury UV lamp emitting light predominantly at 185 and 254 nm. Exposure of real urine to 80 min of UV irradiation resulted in more than 90% degradation of 18 out of 75 OMPs and 1-90% degradation of the remaining OMPs. Enzymatic activity fell below the detection limit for real urine exposed to 71 min of UV irradiation. However, electrical energy demand for reducing enzymatic activity below the detection limit in real fresh urine was 52-fold higher than for inactivation in synthetic fresh urine (without urea), while electrical energy demand was more than 10-fold higher for 90% OMP degradation in real fresh urine than in water. The inactivation and OMP degradation observed were probably due to direct photolysis and photo-oxidation. Presence of organic substances in real urine was the likely reason for less efficient inactivation of urease and OMP degradation, as such substances can competitively absorb incoming UV light and scavenge the free radicals formed during UV treatment. Although 20% urea was lost after UV treatment, there was no decrease in total nitrogen. In summary, UV treatment can stabilise urea-N and degrade OMPs in fresh urine and has potential for integration into urine diversion sanitation systems.

show abstract

Analysis of degradation and pathways of three common antihistamine drugs by NaClO, UV, and UV-NaClO methods

Cited by 11 publications

References 63 publications

Application of Raney Al-Ni Alloy for Simple Hydrodehalogenation of Diclofenac and Other Halogenated Biocidal Contaminants in Alkaline Aqueous Solution under Ambient Conditions

Application of Raney Al-Ni Alloy for Simple Hydrodehalogenation of Diclofenac and Other Halogenated Biocidal Contaminants in Alkaline Aqueous Solution under Ambient Conditions

Pharmaceutical Residues in Edible Oysters along the Coasts of the East and South China Seas and Associated Health Risks to Humans and Wildlife

UV-based advanced oxidation process for nutrient stabilisation and organic micropollutant degradation in source-separated human urine

Contact Info

Product

Resources

About