Analysis of dabigatran prescribing

Gil, Juan; Nicolás, F Gutiérrez; Romero, María Micaela Viña; Gomez, Matilla; Conde, José Antonio Martín; Alonso, Francisco Javier Merino

doi:10.1136/ejhpharm-2012-000074.205

Cited by 2 publications

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“…6,7 In the pharmaceutical area, where the concept of Green Pharmacy is more newsworthy than ever, [8][9][10][11][12][13] the mechanical action is used to produce transformations in molecular crystals to enhance properties such as tableting and bioavailability. [14][15][16][17] But, the applications of mechanochemistry for pharmaceuticals go beyond associations at a supramolecular level, including the improvement of active ingredient synthesis, as well as the design of new potential ones. As an example, Tan et al prepared sulfonyl-(thio)ureas, including anti-diabetic drugs, via mechanosynthesis.…”

Section: Introductionmentioning

confidence: 99%

Solvent-free mechanochemical route for green synthesis of pharmaceutically attractive phenol-hydrazones

et al. 2014

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A series of hydrazones, as potential therapeutic agents, were successfully synthesized in a vibratory ball-mill from various substituted organic hydrazines and phenol aldehydes. The degree of conversion was increased by high electronic density on the amino group of the hydrazine reactant, as well as low steric hindrance around both reactive sites. In this particular case, the flexibility of the chain bearing the amino reactive site of hydrazine was highlighted as a factor influencing the reaction rate. The results showed that hydrazones could be obtained with more than a 99% transformation, without concurring by-products. This is highly adapted to the synthesis of active pharmaceutical ingredients, requiring a high level of purity. Owing to the fact that neither an environmentally unadvisable reagent nor additives or catalysts were added to achieve the transformation, this synthesis provides a good example and a prefiguration of an efficient green pharmaceutical process.

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Section: Introductionmentioning

confidence: 99%

Solvent-free mechanochemical route for green synthesis of pharmaceutically attractive phenol-hydrazones

et al. 2014

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Drug use evaluation of dabigatran in a tertiary care hospital in United Arab Emirates

et al. 2012

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Background Dabigatran etexilate is an oral anticoagulant. It was added to our hospital's formulary in 2010 for the indications of thromboprophylaxis in adult patients following total hip replacement (THR) and total knee replacement (TKR) surgeries and for prevention of thromboembolic stroke in patients with non-valvular atrial fibrillation (AF). Purpose To assess the rational drug use of dabigatran at a tertiary care hospital. Materials and methods The design of the study was a retrospective cross-sectional analysis of all the patients who received dabigatran from September 2011 to April 2012 at Tawam Hospital, United Arab Emirates. The required data were extracted from the electronic patient medical records database and relevant data were collected on patient demographics, indication, dosage regimen, adverse events, contraindications and drug interactions. All patients with AF were previously treated with warfarin and our study population did not include any anticoagulation-naïve patients. Patients with AF were followed every month for 6 months. The duration of treatment was 30 days for all patients who had THR, 10 days for four patients who had TKR and 14 days for two patients who had TKR. They were followed for the time period that they received dabigatran, initially in the ward and then in the outpatient clinic. The data were computed, encoded and statistical analysis was done using SPSS, V.17.0. Result A total of 61 patients (30 cardiology, 29 orthopaedic and 2 general medicine) were included in our study. In the cardiology department, the majority (n=28) of patients were prescribed dabigatran for stroke prevention in non-valvular AF, while two patients received dabigatran for off-label indications. An inappropriate dose was administered in seven patients. In the orthopaedic department, of the 29 patients, 6 had elective TKR, 2 had elective THR and the remaining 21 patients were receiving dabigatran for off-label orthopaedic indications. Hip fracture was the most common off-label indication. There was one documented case of upper gastrointestinal bleeding. Conclusions This study highlights the need to standardise a hospital protocol for dabigatran use within our facility, since a noteworthy proportion of patients were receiving it at incorrect doses and for off-label indications.

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Analysis of dabigatran prescribing

Cited by 2 publications

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Solvent-free mechanochemical route for green synthesis of pharmaceutically attractive phenol-hydrazones

Solvent-free mechanochemical route for green synthesis of pharmaceutically attractive phenol-hydrazones

Drug use evaluation of dabigatran in a tertiary care hospital in United Arab Emirates

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