Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction

Liu, Ruixing; Rong, Bei; Tu, Ping; Tang, Yueh‐Bih; Song, Wenjing; Toyos, Rolando; Toyos, Melissa; Yan, Xiaoming

doi:10.1016/j.ajo.2017.08.021

Cited by 168 publications

(190 citation statements)

References 47 publications

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“…Improvements in dry eye symptomology scores, tear film stability, lipid layer thickness, meibomian gland expressibility and capping, and corneal fluorescein staining have been reported following three to four sessions of IPL therapy in these randomized studies [14,15,28,31,38]. Furthermore, reductions in the expression of IL-6, IL-17A, and PGE2 was observed to be associated with improvements in clinical ocular surface parameters in a recent double-masked, paired eye, randomized, sham-controlled trial [15]. Another double-masked, parallelgroup, randomized, sham-controlled trial reported inhibition of periocular Corneybacterium macginleyi load following four sessions of IPL therapy [14].…”

Section: Clinical Efficacymentioning

confidence: 95%

“…In addition, a recent randomized trial showed that a three-month course of IPL therapy inhibited periocular Corneybacterium macginleyi load [14]. Furthermore, the anti-inflammatory action of IPL therapy has also been demonstrated with the reduction of inflammatory markers in tear samples, including IL-4, IL-6, IL-10, IL-17A, TNF-α, and PGE2 [15,16].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

“…To date, a total of five randomized trials investigating the efficacy of IPL therapy for the treatment of MGD have been published [14,15,28,31,38], as summarized in Table 1, and ongoing randomized trials are highlighted in Table 2. Improvements in dry eye symptomology scores, tear film stability, lipid layer thickness, meibomian gland expressibility and capping, and corneal fluorescein staining have been reported following three to four sessions of IPL therapy in these randomized studies [14,15,28,31,38]. Furthermore, reductions in the expression of IL-6, IL-17A, and PGE2 was observed to be associated with improvements in clinical ocular surface parameters in a recent double-masked, paired eye, randomized, sham-controlled trial [15].…”

Section: Clinical Efficacymentioning

confidence: 99%

See 2 more Smart Citations

The use of intense pulsed light therapy in the treatment of refractory meibomian gland dysfunction

Wang

Khatoon

Craig

2020

Expert Review of Ophthalmology

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Section: Clinical Efficacymentioning

confidence: 95%

Section: Mechanisms Of Actionmentioning

confidence: 99%

Section: Clinical Efficacymentioning

confidence: 99%

See 1 more Smart Citation

The use of intense pulsed light therapy in the treatment of refractory meibomian gland dysfunction

Wang

Khatoon

Craig

2020

Expert Review of Ophthalmology

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“…Dry eye cytokine analysis caused by MGD showed an increase in CX3CL1, IL-1Ra, IL-6, IL-8 / CXCL8, and EGF [12][13][14]. These markers should be further investigated for understanding the antiin lammatory mechanism and posttreatment measurement and a possible relationship with IPL failure [18][19][20].…”

Section: Treatment Eff Ectivenessmentioning

confidence: 99%

Dry eye syndrome: Therapeutic challenges and future trends

Araújo-Neto¹,

Rêgo²,

Araújo‐Filho³

2019

Int J Clin Exp Ophthalmol

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Introduction:Intense Pulsed Light (IPL) is the therapeutic tool implemented in the treatment of dry eye, characterized by the emission of waves of 500-1200nm in the region of the upper and lower eyelids. Dry eye is a recurring complaint in ophthalmology offi ces and has an impact on the patient's quality of life. It results from dysfunction of the meibomian glands, duct obstruction, and quantitative and qualitative changes in glandular secretion. It is manifested by dryness and irritation, foreign body sensation, burning, tearing, and eye fatigue. The available treatments are short term palliative with unsatisfactory results. Objective:To determine through a literature review, the benefi t of using intense pulsed light for dry eye treatment. Methodology: We searched the Cochrane database, PubMed, Embase, Scopus, Web of Science, and Google Scholar (gray literature) using the keywords for an independent, blinded, peer-reviewed selection of articles to be met following pre-established criteria.Results and discussion: Studies evaluated the use of IPL in patients with dry eye, despite the benefi t found, focus on the objective and subjective assessment of the eye more frequently. Conclusion:Evidence-based clinical guidelines are required for the use of intense pulsed light in the treatment of Meibomian Gland Dysfunction (MGD), as well as a device and algorithm for indications of therapeutic use. Dry eye syndrome: Therapeutic challenges and future trends

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“…15 Decreasing the threshold of the pain when the ionic concentration is stabilized on both sides of the cellular membrane during sensitive terminations affects the sensory nerve fibers thereby delaying neuronal depolarization.…”

mentioning

confidence: 99%

Dry Eye Post Surgery Update

Scorsetti¹

2017

Ophthalmol Open J

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CitationThe prevalence of dry eye in the USA is around 11-33% and is directly proportional to age. 3 The main objective to reduce or eliminate dry eye symptoms completely is by implementing new strategies of pre-surgical diagnosis and management.Recent advances in the field of refractive surgery have prioritized visual quality as a primary clinical parameter in the treatment of these patients. Dry eye symptoms are one of the most frequent causes of complaints of those patients who undergo refractive or cataract surgery, most often in the immediate post-operative phase. The patients who undergo cataract surgery show relatively higher chances to present dry eye symptoms following surgery, and most commonly disappears within a short span of time.For this reason, it is important to consider the detection for dry eye syndrome prior to any ocular surgery. In cases where this is confirmed, an appropriate treatment should be performed prior to the proposed surgical procedure, because otherwise one runs the risk of suffering associated complications, for example, error calculation for intraocular lenses in cataract surgery or low post-operative visual quality in refractive surgeries. 4 Patients who already experienced dry eyes before surgery underwent greater discomfort and slower recovery. For some of these patients, most frequently the elderly, who already suffered from dry eyes before surgery, the use of peri-surgery medication, intensive treatment with antibiotics, anti-inflammatory drugs and other highly used drops can result in toxic effects to the ocular surface and consequently lead to dry eye.On the other hand, the inflammatory processes generated during the surgery can lead to tear accessories gland damage, which can be further aggravated in prolonged surgeries (the complicated ones or surgeries performed by residents in training who lack adequate experience) based on the application of photolysis for extensive thermic impact on the ocular surface following an exposure to the light microscope.During phacoemulsification the neurological damage is relatively lesser due to refractive surgeries.On the basis of our knowledge, the cornea is densely populated by sensory nerves originating from the trigeminal ganglion ophthalmic division and the autonomic nervous system; parasympathetic fibers and lesser number of sympathetic nerves arising from the superior cervical ganglion. Corneal nerves are divided into branches in the peripheral cornea.Some of these branches are connected with each other creating the stromal neural net-

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Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction

Cited by 168 publications

References 47 publications

The use of intense pulsed light therapy in the treatment of refractory meibomian gland dysfunction

The use of intense pulsed light therapy in the treatment of refractory meibomian gland dysfunction

Dry eye syndrome: Therapeutic challenges and future trends

Dry Eye Post Surgery Update

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