Analysis of Correlations Relations Between Antioxidant Status Parameters and Dermatological Indices in Rosacea Patients

Котельникова, М; Сімонова, Н.В.; Anokhina, R.A.

doi:10.22448/23115068_2022_1_54

Cited by 1 publication

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“…Самостоятельным направлением применения Цито-флавина® является применение препарата в качестве антиастенического средства [64,77,78]. Показано, что препарат при курсовой терапии (100 таблеток в течение 25 дней) приводит к достоверному уменьшению выраженности как астенического, так и невротического синдромов.…”

Section: анализ результатов клинического применения цитофлавина® при ...unclassified

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

Kim,

Shustov,

Ganapolsky

2024

Psychopharmacology & biological narcology

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This study revealed the pathogenetic patterns of the development of hypoxic and ischemic disorders in various pathological conditions and substantiated approaches to the use of drugs with antihypoxic activity. The role of the receptor interaction of succinic acid in the composition of succinate-containing antihypoxants with succinate receptor SUCNR1 has been demonstrated. The pharmacodynamic properties of the combined preparation of succinic acid that also contains vitamin precursors of the cofactors of Krebs cycle dehydrogenases nicotinamide (precursor of NAD) and riboflavin mononucleotide (precursor of FAD) and precursor of purine nucleotides (inosine) (cytoflavin) for intravenous drip and oral administration were analyzed. Literature data were also analyzed to evaluate the effectiveness of the use of the metabolic corrector of energy-dependent and hypoxic conditions (cytoflavin) in various central nervous system and cardiovascular diseases. In the case of ischemic disorders of cerebral and coronary blood flow, the effects of the drug are concentrated on the penumbra zone (ischemic penumbra), which is associated with the intravenous administration of the drug to its metabolic activity by influencing endothelial cells, restoring microcirculation, and enhancing the oxygen transport function of the blood. Among the new areas of drug use, the use of cytoflavin in the complex therapy of traumatic brain injuries, traumatic shock, acute respiratory distress syndrome, toxic lesions of the central nervous system, multiple organ failure syndrome, and post-COVID syndrome is promising.

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Section: анализ результатов клинического применения цитофлавина® при ...unclassified

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

Kim,

Shustov,

Ganapolsky

2024

Psychopharmacology & biological narcology

View full text Add to dashboard Cite

show abstract

Analysis of Correlations Relations Between Antioxidant Status Parameters and Dermatological Indices in Rosacea Patients

Cited by 1 publication

References 0 publications

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

Pathogenetic and pharmacodynamic features of succinic acid derivative application for various diseases of the cardiovascular and nervous systems

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