Analysis of Correlations Between Selected Blood Markers of Liver Function and Milk Composition in Cows During Late Lactation Period

Abstract

The knowledge of the existing levels and the interrelationships between various blood and milk parameters is very useful for the analysis and monitoring of homeostasis high-yielding dairy cows. The aim of the study was to evaluate these values and correlations for selected blood markers of liver function aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), bilirubin, albumin, glucose, cholesterol) and selected milk parameters: somatic cell count (SCC), colony-forming units (CFU), fat, protein, lactose, dry matter (DM), fat-free dry matter (FDM), and milk production in cows during late lactation period. At the same time blood and milk samples were collected from 11 clinically healthy milking cows in later lactation period. The 11 selected cows were examined once a day for 3 days resulting in 33 sets of blood and milk samples for laboratory and statistical analysis. Significant positive correlations were observed between: ALT and albumin, ALT and cholesterol, GGT and glucose, albumin and cholesterol, CFU and fat, CFU and DM, SCC and protein, fat and DM, protein and FDM, lactose and FDM, GPT and FDM, albumin and protein, albumin and FDM, glucose and fat, as well as significant negative correlations between: AST and ALT, AST and GGT, AST and albumin, CFU and lactose, fat and lactose, fat and FDM, lactose and DM, DM and FDM, AST and SCC, AST and protein, AST and FDM, ALT and fat, ALT and DM, glucose and DM, cholesterol and CFU. The results obtained may be important for detecting of different biochemical pathways and helpful in estimating, predicting or determining trends, the direction of changes in liver functions and assessing the risk of alert levels for liver blood markers, when only daily results of milk parameters are available.

The effect of protein supplement from skin wastes on hematological, biochemical metabolic indices and dairy productivity of highly yielding cows

“…). The absence of pathological changes in the liver, as well as the metabolic rate, is to some extent indicated by an increase in the main hepatic enzymes ALT and AST along with increased albumin and cholesterol levels in the blood serum of animals treated with RUP supplement (Mordak et al, 2020). Hematological indicators of lactating cows of all studied groups at all stages of the experiment were within the physiological norm (Table 7).…”

Relationships among Macro-Minerals, Other Selected Serum Markers of Bone Profile and Milk Components of Dairy Cows During Late Lactation

“…Results of these analyses were also presented and discussed in the previous research (Mordak et al, 2020).…”

“…However, during particular life phases such as peripartum, and particularly lactation, female mammals have to adapt to physiological demands and adaptation, thus the comparison with established reference intervals becomes complicated (Arfuso et al, 2016, Fiore et al 2017. Relationships between contents of biochemical metabolites in blood and milk in highly productive dairy cows are important not only during transition or early lactation period but also during other stages of milk such as mid-lactation and late-lactation when the daily values of milk are also high (Nozad et al, 2012, Djokovic et al, 2019, Mordak et al, 2020.…”

“…Milk yield and composition, especially in terms of protein, lactose, fat, number of somatic cells and many other components depends on many factors such as the type of feed dose, the season, and the cow's health, including the udder, which can significantly affect the state of homeostasis of individual organs and tissues including blood (Cozzi et al, 2011, Bobbo et al, 2017, Mordak et al, 2020. Numerous blood parameters are commonly used in diagnostics, but blood proteins, including albumin, can be very important in relation to milk composition in both physiological and pathological conditions (Bondan et al, 2018).…”

Prediction of Reproductive Success in Multiparous First Service Dairy Cows by Parameters from In-Line Sensors

“…Albumins are also negative acute-phase proteins and their low serum levels can be found in various acute or chronic inflammations [28]. In the cows tested, slightly reduced serum albumin levels may have been caused by testing and a slightly reduced feed intake, which only confirmed the need to monitor the internal homeostasis of high-yielding animals [29].…”