Analysis of Correlation between Age and Satisfied Total Weight Loss Percentage Outcome at 1 Year after Bariatric Surgery using the Restricted Cubic Spline Function: A Retrospective Study in China

Li, Zhehong; Chen, Guanyang; Wang, Liang; Wuyun, Qiqige; Sang, Qing; Wang, Jing; Tian, Chenxu; Shang, Mingyue; Wang, Zheng; Du, Dexiao; Zhang, Nengwei

doi:10.1007/s11695-023-06691-3

Cited by 1 publication

(1 citation statement)

References 32 publications

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“…However, from 9 months after surgery, results using the %TWL have shown a significant trend of better outcomes for patients with higher BMI, especially in the case of RYGB [60]. Furthermore, the cut-off point for the %TWL is unclear, with some studies using 20% [61][62][63][64] and others using 25% [65][66][67]. A comparison of the obtained results relating to QoL/depression, miRNAs and adipocytokines with these two indices, %EWL vs. %TWL, is not the aim of the present study.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Depressive Symptoms, Quality of Life and miRNAs 8 Years after Bariatric Surgery

Mela,

Agüera,

Alvarez-Bermudez

et al. 2023

Nutrients

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(1) Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. (2) Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into “good responders” and “non-responders” depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. (3) Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning—physical, role functioning—emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. (4) Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.

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