Analysis of Community-Acquired Urinary Tract Infection Treatment in Pediatric Patients Requiring Hospitalization: Opportunity for Use of Narrower Spectrum Antibiotics

Stultz, Jeremy S.; Francis, Natalie; Ketron, Samantha; Bagga, Bindiya; Shelton, Chasity M.; Lee, Kelley R.; Arnold, Sandra R.

doi:10.1177/8755122520964435

Cited by 8 publications

(5 citation statements)

References 29 publications

(55 reference statements)

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“…Among the 54 included studies, 3,12–69 42 (78%) described infections and 12 (22%) described colonization with at least one of the pathogens of interest ( Table 1 ). 13,18,26,33,37,43,45,47,50,51,53–55,57 Most studies were from the USA (n=42), 3,14–17,20,21,21,23–28,30–33,37,38,40–42,44–51,53–63,67–69 although studies from Israel (n=5), 13,29,34,36,39,52 New Zealand (n=4), 12,43,64–66 Australia (n=2), 19,35 and Brazil (n=1) 18 were also identified ( Figure 1 ). Studies of infection most often included patients with skin and soft tissue infection (SSTI) caused by S. aureus or urinary tract infection (UTI) caused by E. coli or other Enterobacterales, while other infections like community-acquired pneumonia (CAP) were described more rarely.…”

Section: Resultsmentioning

confidence: 99%

“…Ten cohorts in twelve publications reported Hispanic as an ethnicity ( Table 4 ). 14,17,22,24,25,30,37,40,47,51,61,63 MRSA or S. aureus was reported in eight studies with conflicting results, E. coli was reported in three with two reporting higher risk in Hispanic persons, K. pneumoniae was reported in one, P. aeruginosa in one, SSTI in one, and UTI in one.…”

Section: Resultsmentioning

confidence: 99%

“…24,30,61 Three studies reported E. coli infections in Hispanic persons. 22,61,63 One pediatric study reported that Hispanic children were at a higher risk than non-Hispanic children for E. coli UTIs that were non-susceptible to first-generation cephalosporin antibiotics. 63 Another study 22 that reported on two adult cohorts recruited from an outpatient population found that Hispanic adults compared to non-Hispanic adults were at a higher risk of MDR vs non-MDR E. coli infections, while a third study 61 did not report on the comparison for Hispanic vs non-Hispanic White persons for infections caused by E. coli versus other pathogens.…”

Section: Hispanic Vs Non-hispanic Personsmentioning

confidence: 99%

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Race, ethnicity, and risk for colonization and infection with key bacterial pathogens: a scoping review

Avendano,

Blackmon,

Nirmala

et al. 2024

Preprint

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Background: Racial and ethnic disparities in infectious disease burden have been reported in the USA and globally, most recently for COVID-19. It remains unclear whether such disparities also exist for priority bacterial pathogens that are increasingly antibiotic-resistant. We conducted a scoping review to summarize published studies that report on colonization or community-acquired infection with pathogens among different races and ethnicities. Methods: We conducted an electronic literature search of MEDLINE, Daily, Global Health, Embase, Cochrane Central, and Web of Science from inception to January 2022 for eligible observational studies. Abstracts and full-text publications were screened in duplicate for studies that reported data for race or ethnicity for at least one of the pathogens of interest. Results: Fifty-four observational studies in 59 publications met our inclusion criteria. Studies reported results for Enterobacterales,Enterococcus faecium,Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa, andStaphylococcus aureus, and were conducted in Australia, Brazil, Israel, New Zealand, and USA. USA studies most often examined Black and Hispanic minority groups with studies regularly reporting a higher risk of these pathogens in Black persons and mixed results for Hispanic persons. Ethnic minority groups (e.g.Bedouins in Israel, Aboriginals in Australia) were often reported to be at a higher risk in other countries. Conclusion: Sufficient evidence was identified in this scoping review justifying future systematic reviews and meta-analyses evaluating the relationship between community-acquired pathogens and race and ethnicity. However, we noted that only a fraction of studies reported data stratified by race and ethnicity, highlighting a substantial gap in the literature.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Hispanic Vs Non-hispanic Personsmentioning

confidence: 99%

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Race, ethnicity, and risk for colonization and infection with key bacterial pathogens: a scoping review

Avendano,

Blackmon,

Nirmala

et al. 2024

Preprint

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“…Guideline development followed by PAF for targeted antibiotics was the cornerstone strategy of initiatives for our ASP. We previously reported on guideline creation for linezolid use and urinary tract infection treatment [ 14 , 15 ]. Table 1 provides a complete list of ASP initiatives and guideline revisions since program initiation.…”

Section: Methodsmentioning

confidence: 99%

A Culture Change: Impact of a Pediatric Antimicrobial Stewardship Program Based on Guideline Implementation and Prospective Audit with Feedback

et al. 2021

Self Cite

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Reports analyzing the impact of pediatric antimicrobial stewardship programs (ASP) over long periods of time are lacking. We thus report our ASP experience in a pediatric tertiary referral center over a long-term period from 2011 to 2018. Our ASP was implemented in 2011. The program was based primarily on guideline development with key stakeholders, engaging and educating providers, followed by prospective audit with feedback (PAF). Monitored antibiotics included meropenem, piperacillin–tazobactam, and cefepime, followed by the addition of ceftriaxone, ceftazidime, cefotaxime, ciprofloxacin, levofloxacin, linezolid, and vancomycin at various time points. Specifically, the program did not implemented the core strategy of formulary restriction with prior authorization. Process- and outcome-related ASP measures were analyzed. We saw a 32% decrease in overall antibiotic utilization, a 51% decrease in the utilization of antibiotics undergoing PAF, and a 72% reduction in the use of broad-spectrum antibiotics such as meropenem. There was a concomitant increase in organism susceptibility and a reduction in yearly drug purchasing costs of over USD 560,000 from baseline without changes in sepsis-related mortality. Our study highlights that a pediatric ASP based primarily on the principles of guideline development and PAF can improve antibiotic utilization and institutional bacterial susceptibilities without a detrimental impact on patient outcomes by changing the culture of antimicrobial utilization within the institution.

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“…Até 8% das crianças terão pelo menos uma ocorrência de ITU entre as idades de 1 mês e 11 anos, e até 30% dos bebes e crianças, durante os primeiros seis a doze meses, apresentam infecções recorrentes de ITU . Aproximadamente 5 das crianças que dão entrada no pronto-socorro com suspeita de ITU requerem internação hospitalar (STULTZ et al, 2021).…”

Section: Introductionunclassified

Teste Do Coraçãozinho Vivenciado Na Disciplina Do Estágio Saúde Da Mulher. Um Relato De Experiência Dos Acadêmicos De Enfermagem Da Unisuam

Oliveira¹

2022

Enfermagem: Investigação Científica, Ensino E Assistência

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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Analysis of Community-Acquired Urinary Tract Infection Treatment in Pediatric Patients Requiring Hospitalization: Opportunity for Use of Narrower Spectrum Antibiotics

Cited by 8 publications

References 29 publications

Race, ethnicity, and risk for colonization and infection with key bacterial pathogens: a scoping review

Race, ethnicity, and risk for colonization and infection with key bacterial pathogens: a scoping review

A Culture Change: Impact of a Pediatric Antimicrobial Stewardship Program Based on Guideline Implementation and Prospective Audit with Feedback

Teste Do Coraçãozinho Vivenciado Na Disciplina Do Estágio Saúde Da Mulher. Um Relato De Experiência Dos Acadêmicos De Enfermagem Da Unisuam

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