Analysis of cohesion forces between monodisperse microparticles with rough surfaces

Baldelli, Alberto; Vehring, Reinhard

doi:10.1016/j.colsurfa.2016.06.009

Cited by 45 publications

(22 citation statements)

References 72 publications

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“…32 The Dusttrak II instrument was fitted with the PM 10 filter (according to manufacturer's instructions) for all experiments on the basis that it would detect up to the largest sized particles which would be capable of reaching the alveoli. 29 The Dusttrak II was used to determine the concentration of aerosols under 10 lm in the environment and a Qtrak (7565 model TSI Inc.) was used to measure parameters such as temperature and humidity.…”

Section: Particulate Matter Detection -Instrumentation Validationmentioning

confidence: 99%

“…27,28 There is much research into the generation of aerosols that are capable of reaching the lungs for medicinal and therapeutic treatments. 29,30 It is also known that disturbing the air above a water source, as well as agitation of water surfaces, will increase the amount of aerosols generated by it. This is precisely what is observed in a typical toilet flush though admittedly the temperature and relative humidity of the agitated water and air around the water in a toilet would likely be considerably less than in a whirlpool device scenario.…”

Section: Introductionmentioning

confidence: 99%

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To mix or not to mix: Parental attitudes towards translanguaging and language management choices

Wilson

2020

International Journal of Bilingualism

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Aim and objectives: The present study investigates parental language beliefs and management among French-English bilingual families in the UK. It addresses the following two research questions. (a) What are parents’ attitudes towards translanguaging and beliefs about effective language management? (b) Do these beliefs and attitudes translate into language separation strategies versus flexible language practices? Design/methodology: This paper reports part of the results of a mixed-method study consisting of an online survey as well as multiple in-depth case studies. The qualitative portion of the present article focuses on two case studies including face-to-face interviews and observations in the family home. Data and analysis: Responses to the online questionnaire ( n = 164) were analysed using descriptive statistics. Thematic analysis was used for interview data. Observations were analysed through the Family Language Policy framework and by looking at turn-taking sequences and meta-linguistic comments. Results: Parental ideologies appear to have evolved towards more positive attitudes towards language mixing. However, these positive attitudes towards translanguaging do not necessarily result in flexible language practices at home. Findings/conclusions: Language separation strategies such as one parent–one language may be adopted not as a result of ideologies, but despite parents’ beliefs about the flexible nature of bilingualism and owing to the pressure experienced by parents to develop children’s heritage language (HL) proficiency. Originality: The findings contradict previous studies, which reported the predominance of monoglossic language ideologies among middle-class parents. They suggest that parental language beliefs may have evolved and that a translingual ideology is making its way into multilingual families. Significance/implications: The study suggests that practical support in the form of additional sources of HL input, rather than theoretical guidance, would be required for parents to embrace flexible language management at home. The present study findings also highlight the dilemma parents face between prioritising their children’s bilingual development and fostering a harmonious bilingual environment for their families.

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Section: Particulate Matter Detection -Instrumentation Validationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

To mix or not to mix: Parental attitudes towards translanguaging and language management choices

Wilson

2020

International Journal of Bilingualism

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“…Such heterogeneous surface distributions may have significant impact on dispersion behavior due to changes in particle density, morphology and surface energy, which have been investigated extensively. (48, 53–55) This study focuses on effects of such heterogeneous surface distributions on dissolution behavior of composite particles. Since wetting and dissolution of particles begin at the surface of the particles; the surface composition can have a dominating effect on the dissolution of the particle formulation (56).…”

Section: Discussionmentioning

confidence: 99%

Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

Mangal

Park

et al. 2018

Pharm Res

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Purpose: Dissolution behavior of dry powder inhaler (DPI) antibiotic formulations in the airways may affect their efficacy especially for poorly-soluble antibiotics such as azithromycin. The main objective of this study was to understand the effects of surface composition on the dissolution of spray dried azithromycin powders by itself and in combination with colistin. Methods: Composite formulations of azithromycin (a poorly water-soluble molecule) and colistin (a water-soluble molecule) were produced by spray drying. The resultant formulations were characterized for particle size, morphology, surface composition, solid-state properties, solubility and dissolution. Results: The results demonstrate that surfaces composition has critical impacts on the dissolution of composite formulations. Colistin was shown to increase the solubility of azithromycin. For composite formulations with no surface colistin, azithromycin released at a similar dissolution rate as the spray-dried azithromycin alone. An increase in surface colistin concentration was shown to accelerate the dissolution of azithromycin. The dissolution of colistin from the composite formulations was significantly slower than the spray-dried pure colistin. In addition, FTIR spectrum showed intermolecular interactions between azithromycin and colistin in the composite formulations, which could contribute to the enhanced solubility and dissolution of azithromycin. Conclusions: Our study provides fundamental understanding of the effects of surface concentration of colistin on azithromycin dissolution of co-spray-dried composite powder formulations.

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“…54 The difference in deposition properties between porous and unpredictable particles is influenced by differences in the degree of cohesiveness of each particle. 55 From various studies conducted, a conclusion is drawn that porous particles can be deposited more deeply on the inside, but tend to avoid phagocytosis by macrophages. Some examples of porous particles given by the inhalation route are presented in Table 5.…”

Section: Surface Properties Of Particlesmentioning

confidence: 99%

Microsphere-Based Drug Delivery to Alveolar Macrophages - a Review

2020

TJNPR

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Lungs have a complex but coordinated system to eliminate inhaled pathogenic and pollutant particles. Pulmonary contact with pathogenic particles has the potential to cause respiratory disturbances, so the process of eliminating foreign particles must be ensured to continue functioning normally. Pulmonary delivery system becomes the choice of drug delivery, for example in the provision of inhaled antibiotics aimed at several diseases such as tuberculosis and pneumonia. This delivery route is also intended for the treatment of pulmonary hypertension 1 and the administration of paclitaxel and doxurobicin in the treatment of lung cancer. 2 In several studies that have been carried out, inhalation delivery system is also intended to have a systemic effect, for example insulin delivery, 3 delivery of antinerve growth factor hormone, 4 and antithrombotic therapy. 5 Lungs' natural defense mechanism to fight pollutants and potentially pathogenic particles is a complex system and involves several processes such as mucociliary cleansing, the release of anti-pathogenic endogenous proteins, and the presence of leukocyte responses that occur in the lungs. 6 Alveolar macrophages are the first defense

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Analysis of cohesion forces between monodisperse microparticles with rough surfaces

Cited by 45 publications

References 72 publications

To mix or not to mix: Parental attitudes towards translanguaging and language management choices

To mix or not to mix: Parental attitudes towards translanguaging and language management choices

Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

Microsphere-Based Drug Delivery to Alveolar Macrophages - a Review

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