Analysis of Clostridium difficile infections in patients hospitalized at the nephrological ward in Poland

Kujawa-Szewieczek, Agata; Adamczak, Marcin; Kwiecień, Katarzyna; Dudzicz, Sylwia; Z, Prazák; Wiȩcek, Andrzej

doi:10.5604/17322693.1202187

Cited by 8 publications

(9 citation statements)

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“…9,10 Similarly, in one of the few Polish publications related to the CD infection in nephrology wards, the prevalence of 9.9/1000 hospitalizations was reported. 8 High prevalence of the CD infection in CKD patients of our Department confirms our observations, indicating a higher prevalence of the infection in nephrological patients when compared both to the general population and to patients hospitalized in other wards. 6,11 It also indicates that CKD, especially class 5, is an independent risk factor of the CD infection.…”

Section: Discussionsupporting

confidence: 89%

“…[4][5][6] In recent years, a number of reports have appeared, indicating an increased incidence and morbidity of CD-associated infections in patients with chronic kidney disease (CKD). 7,8 These observations corroborated current clinical experience in our Department, which is why we sought to assess the incidence, morbidity and risk factors of the CD infection in our CKD patients.…”

Section: Introductionsupporting

confidence: 73%

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Risk factors of the Clostridium difficile infection in patients with chronic kidney disease

Lis¹,

P²,

Konieczny³

et al. 2018

Adv Clin Exp Med

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In patients with CKD, longer hospitalization time and lower serum albumin concentration significantly increased the risk of the C. difficile infection. The C. difficile infection, age, the number of used antibiotics, longer hospitalization time, and lower initial serum albumin concentration notably augmented the risk of death. Although the incidence of the C. difficile infection did not correlate with the estimated glomerular filtration rate (eGFR), 67% of patients who tested positive were class 5 of CKD, whereas only 5.7% were class 1.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionsupporting

confidence: 73%

Risk factors of the Clostridium difficile infection in patients with chronic kidney disease

Lis¹,

P²,

Konieczny³

et al. 2018

Adv Clin Exp Med

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“…Objawy zakażenia CDI często występują po przeprowadzeniu antybiotykoterapii, szczególnie z zastosowaniem fluorochinolonów, penicylin + inhibitor, karbapenemów, cefalosporyn oraz klindamycyny. Zakażenie częściej jest diagnozowane u osób starszych, obciążonych współistniejącymi chorobami, po przeszczepach narządów, hospitalizowanych oraz przebywających w domach długoterminowej opieki [5,19]. W analizie Ulatowskiej i wsp.…”

Section: Dyskusjaunclassified

“…Obecnie Clostridium difficile (CD) jest jednym z najważniejszych czynników etiologicznych zakażeń szpitalnych na świecie [2], również w Polsce [3,4,5]. Zakażenia CDI w głównej mierze są konsekwencją zastosowania u pacjentów w podeszłym wieku inhibitorów pompy protonowej (IPP) oraz antybiotykoterapii (leki wysokiego ryzyka: klindamycyna, fluorochinolony, cefalosporyny; leki średniego ryzyka, np.…”

Section: Introductionunclassified

Assessment of Clostridium difficile risk in the Provincial Hospital

Ziółkowski¹,

Pawłowska²,

Pełka³

et al. 2018

Medicine

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“…The most commonly used groups of antibiotics were: fluoroquinolones (46%), penicillins (32%), carbapenems and monobactams (27%) and cephalosporins (24%). The onset of CDI symptoms was on average nine days after starting antibiotic treatment [28]. …”

Section: Clostridium Difficile Infection In Patients Hospitalized In mentioning

confidence: 99%

Clostridium Difficile Infection in the Nephrology Ward

Dudzicz¹,

Adamczak²,

Wiȩcek³

2017

Kidney Blood Press Res

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Clostridium difficile is currently the most frequently identified pathogen causing antibiotic-associated diarrhea and the main cause of nosocomial diarrhea. In recent years, increases incidence of infection, severe infection, recurrent infection and mortality from Clostridium difficile infection (CDI) have been observed. This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain of Clostridium difficile. The main risk factors for CDI are: antibiotic therapy, previous hospitalizations and number of comorbid conditions. Prevention of CDI mainly is focused in two directions: reducing the exposure of patients to the disease pathogen by intensifying hygiene measures, and reducing the impact of risk factors. A meta-analyses of clinical studies (observational, cohort and case control) showed significantly higher risk of CDI and CDI recurrence in patients with chronic kidney disease and increased mortality risk in chronic kidney disease patients with CDI comparing those without CDI. Increased risk of CDI in patients with chronic kidney disease can be caused by: frequent antibiotic therapy associated with numerous infections resulting in intestinal microflora dysfunction, frequent hospitalizations, older age of the patients and an impaired immune system. Among preventative measures against CDI, the use of probiotics were also studied. In patients hospitalized in nephrology ward highly significant reduction of the CDI incidence was observed after the introduction of Lactobacillus plantarum 299v as CDI prophylaxis. Therefore, the use of Lactobacillus plantarum 299v seems to be a promising method of CDI prevention in chronic kidney disease patients hospitalized in nephrology ward.

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Analysis of Clostridium difficile infections in patients hospitalized at the nephrological ward in Poland

Abstract: 1. Clostridium difficile infection is particularly common among patients in the early period after solid organ transplantation. 2. Clostridium difficile infection may lead to irreversible deterioration of transplanted kidney function.

Cited by 8 publications

References 0 publications

Risk factors of the Clostridium difficile infection in patients with chronic kidney disease

Risk factors of the Clostridium difficile infection in patients with chronic kidney disease

Assessment of Clostridium difficile risk in the Provincial Hospital

Clostridium Difficile Infection in the Nephrology Ward

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