Analysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma – Retrospective analysis of 517 patients

Safi, Ali-Farid; Kauke, Martin; Grandoch, Andrea; Nickenig, Hans-Joachim; Zöller, Joachim E.; Kreppel, Matthias

doi:10.1016/j.jcms.2017.07.012

Cited by 29 publications

(20 citation statements)

References 25 publications

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“…Its presence therefore merits intensification of adjuvant therapy (Chen et al., 2016; Jardim et al., 2015; Liao et al., 2018; Mermod, Tolstonog, Simon, & Monnier, 2016; Rajappa et al., 2019; Rogers et al., 2009; Suton et al., 2017; Wong et al., 2012; Zanoni et al., 2019). As reported by other groups, the tumour's histopathological grading has a significant influence on OS, DFS and LRC (Camisasca et al., 2011; Chen et al., 2016; Ermer et al., 2015; Rogers et al., 2009; Safi et al., 2017; Yanamoto et al., 2012; Zanoni et al., 2019). However, probably because of the subjective aspect of grading, some researchers do not (Wong et al., 2012) or do only partially (Woolgar, 2006) confirm this influence of grading on the patient's prognosis.…”

Section: Discussionmentioning

confidence: 66%

“…A delay in diagnosis is one of the main reasons for the bad prognosis of recurring OSCC (Camisasca et al., 2011; Ermer et al., 2015; Safi et al., 2017; Vázquez‐Mahía et al., 2012). Individualized surveillance programmes based on the risk of recurrence and the patient's prognosis could make an earlier diagnosis possible.…”

Section: Discussionmentioning

confidence: 99%

“…Relapse was defined as a tumour of similar histology appearing minimally 6 weeks after primary treatment (Safi et al., 2017; Vázquez‐Mahía et al., 2012). The period of record ended at the 31st of December 2016.…”

Section: Methodsmentioning

confidence: 99%

“…Tumour relapse remains one of the major problems in managing oral squamous cell carcinoma (OSCC) and is associated with a dramatic worsening of the patient's prognosis. After curative intended surgery and appropriate adjuvant therapy, recurrence rates of up to 47% have been reported (González‐García, Naval‐Gías, Román‐Romero, Sastre‐Pérez, & Rodríguez‐Campo, 2009; Safi et al., 2017; Shinn et al., 2018; Weckx et al., 2019; Yanamoto et al., 2012). The 5‐year overall survival decreases from 70% to 30% in case of a relapse (Camisasca et al., 2011; Ermer et al., 2015; Safi et al., 2017; Vázquez‐Mahía et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

“…After curative intended surgery and appropriate adjuvant therapy, recurrence rates of up to 47% have been reported (González‐García, Naval‐Gías, Román‐Romero, Sastre‐Pérez, & Rodríguez‐Campo, 2009; Safi et al., 2017; Shinn et al., 2018; Weckx et al., 2019; Yanamoto et al., 2012). The 5‐year overall survival decreases from 70% to 30% in case of a relapse (Camisasca et al., 2011; Ermer et al., 2015; Safi et al., 2017; Vázquez‐Mahía et al., 2012). Several explanations have been described for this poor prognosis of recurrent disease, such as a depletion of therapeutic options after combination therapy, a more aggressive tumour biology and an impact of the previous treatment on the patient's general condition (González‐García et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

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Survival outcomes after surgical treatment of oral squamous cell carcinoma

et al. 2020

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Objective To identify the clinicopathological parameters that influence survival in patients with oral squamous cell carcinoma, in order to allow for the development of individualized surveillance programmes and reduce the delay in diagnosis of recurrence. Materials and Methods Retrospective chart review of 553 patients with a treatment‐naïve primary oral squamous cell carcinoma, who underwent primarily curative intended surgery. Exclusion criteria were neoadjuvant radio(chemo)therapy, follow‐up < 1 year, perioperative death, inoperable disease, synchronous multiple malignancies and inadequate information on clinicopathological parameters. Results The clinicopathological factors that influence overall survival, disease‐free survival and locoregional control were calculated. In the multivariate survival analysis, the occurrence of recurrence, presence of extracapsular spread, T‐ and N‐classification were shown to be independent risk factors for overall survival. Conclusion The identification of these risk factors can lead to the development of individualized follow‐up programmes based on risk stratification. This allows for the earliest possible diagnosis of relapse which is essential to offer the patient a realistic second treatment chance and to improve survival rates.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Survival outcomes after surgical treatment of oral squamous cell carcinoma

et al. 2020

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A novel histopathological scoring system for patients with oral squamous cell carcinoma

et al. 2019

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Improved recurrence rates and progression-free survival in primarily surgically treated oral squamous cell carcinoma – results from a German tertiary medical center

Struckmeier,

Buchbender,

Lutz

et al. 2024

Clin Oral Invest

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Objectives This study aimed to explore survival and recurrence patterns in patients undergoing primarily surgical treatment for oral squamous cell carcinoma (OSCC) at a high-volume tertiary medical center in Germany. Materials and methods The study included 421 patients with primary OSCC who underwent radical tumor resection, neck dissection, and reconstruction with a free flap. Prognostic relevance of clinicopathological characteristics was assessed using Cox proportional-hazards models. Kaplan-Meier method estimated local recurrence-free survival, progression-free survival (PFS), and overall survival (OS), while the log-rank test compared survival outcomes between groups. Results Recurrence manifested in 16.63% of the patients (70 patients), encompassing local recurrence in 54 patients (77.14%) and distant metastasis in 24 patients (34.28%). Neck recurrence occurred in only 1 patient (0.24%) on the contralateral side. The majority of recurrences occurred within the initial twelve months following primary tumor surgery (64.29%). Overall, the 5-year OS stood at 58.29%, while the 5-year PFS reached 72.53%. Patients with early recurrence within ≤ 12 months showed the least favorable prognosis (log-rank, all p < 0.001). Conclusions Our findings show a significant decrease in recurrence rates and enhanced PFS at a high-volume tertiary medical center in Germany compared to previous studies. Local recurrence was the primary form observed, with most recurrences happening within the initial twelve months post-surgery. Opting for treatment at a high-volume center and devising therapy plans in interdisciplinary tumor boards may not only enhance OS but also contribute to improved PFS. Clinical relevance These findings offer valuable insights for physicians regarding the post-treatment care of patients with OSCC. The results underscore the importance of frequent follow-up appointments, particularly during the initial year, and highlight the critical need for vigilance in monitoring for local recurrence.

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Analysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma – Retrospective analysis of 517 patients

Cited by 29 publications

References 25 publications

Survival outcomes after surgical treatment of oral squamous cell carcinoma

Survival outcomes after surgical treatment of oral squamous cell carcinoma

A novel histopathological scoring system for patients with oral squamous cell carcinoma

Improved recurrence rates and progression-free survival in primarily surgically treated oral squamous cell carcinoma – results from a German tertiary medical center

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