Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle

Shirakura, Takuo; Yamada, Yuichi; Nakata, Satoshi; Asayama, Bunsho; Seo, Yoshinobu; Tanikawa, Satoshi; Kato, Takayuki; Komoribayashi, Nobukazu; Kubo, Naohiko; Monma, Nobuhiro; Okura, Naoki; Tanaka, Shinya; Oda, Yoshinao; Hirato, Junko; Yokoo, Hideaki; Nobusawa, Sumihito

doi:10.1007/s00428-022-03403-7

Cited by 5 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both cases were cellular SFTs and exhibited marked areas of periductal hyalinization (Figure 4). Although rare, SFTs developing in the major salivary glands (Boschetti et al, 2022; Goker et al, 2022) and, more rarely involving ectopic salivary glands of the cerebellum have been reported (Shirakura et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Oral solitary fibrous tumors: A collaborative clinicopathologic study of 19 cases

Cunha,

Cavalcante,

Barros

et al. 2023

Oral Diseases

View full text Add to dashboard Cite

ObjectiveTo report the clinicopathologic features of 19 oral solitary fibrous tumors (SFTs).MethodsClinical data were collected from the records of seven pathology services. All cases were re‐evaluated by HE staining and confirmed by immunohistochemistry.ResultsThe series comprised 11 females (57.9%) and 8 males (42.1%), with a mean age of 47.3 ± 14.7 years (range: 22–71 years) and a 1.3:1 female‐to‐male ratio. Most tumors affected the buccal mucosa (n = 7; 36.8%) and presented clinically as an asymptomatic solitary submucosal well‐circumscribed nodule with coloration similar to the oral mucosa. Morphologically, most SFTs (n = 10; 52.6%) exhibited a classic hybrid pattern characterized by a well‐circumscribed proliferation of densely cellular areas alternating with hypocellular areas in a variably collagenous vascular stroma. Remnants of accessory salivary glands were observed in two cases (n = 2; 10.5%). All tumors were positive for STAT6 and CD34 (n = 19; 100%). Outcome information was available from 6 patients (31.6%), with clinical follow‐up ranging from 6 to 24 months (mean ± SD, 9.5 ± 6.8 months), and none developed local recurrence.ConclusionsOral SFTs are rare and often clinically misdiagnosed. Pathologists should consider SFT in the differential diagnosis of oral spindle cell tumors. Accurate diagnosis requires careful morphological evaluation supported by immunohistochemical analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Oral solitary fibrous tumors: A collaborative clinicopathologic study of 19 cases

Cunha,

Cavalcante,

Barros

et al. 2023

Oral Diseases

View full text Add to dashboard Cite

show abstract

“…Concerning the genetic signatures that are implicated in the onset of STF, the discovery of fusion genes between NAB2 and STAT6 in 2013 was determinant to expand knowledge on the molecular subtypes involved in SFT (6). More specifically, the fusion gene variants, NAB2 exon 4-STAT6 exon 2/3 and NAB2 exon 5/6/7-STAT6 exon 16/17/18 are identified in meningeal STFs, but all of them could play an important role for future therapies independently of the histological origin of STFs (47). Interestingly, STFs that are derived from the salivary glands and cases that demonstrate ectopic salivary glands are very rare in the intracranial environment.…”

Section: Conclusion: To Our Knowledge This Is the Second Reported Cas...mentioning

confidence: 99%

Solitary Fibrous Tumor of the Masticator Space withUnusual Extension: a Case Report

GIOTAKIS,

ZARACHI,

DERKA

et al. 2024

Maedica

View full text Add to dashboard Cite

Background: We present the case of a patient with solitary fibrous tumor of the masticator space with unusual extension.Case presentation: A 43-year-old woman presented with a painless mass with intraoral extension on the right cheek. The B-scan sonograph and magnetic resonance imaging revealed the extension of the tumor. The biopsy performed under local anesthesia raised the suspicion of a solitary fibrous tumor. Tumor excision included a preoperative tumor embolization. The surgical removal of the tumor included a partial parotidectomy on the right side, insertion of masseteric and temporalis muscle, resection of the middle part of the zygomatic bone and stabilization of the bone with a plate, mobilization of the tumor from the maxillary sinus and the pterygopalatine fossa through an endoscopic approach and an approach via partial resection of the anterior wall of the maxillary sinus after identifying and sparing the infraorbital nerve. Τhe histological findings confirmed the diagnosis of solitary fibrous tumor. The patient's treatment completed with radiation therapy, and 2.5 years later, there was recurrence in the right temporal area.

show abstract

“…This change is supported by a shared molecular hallmark, the chromosomal inversion at the 12q13 locus, which fuses the NGFI-A-binding protein 2 (NAB2) and the signal transducer and activator of transcription 6 (STAT6) genes [3]. NAB2-STAT6 fusion variants have been identified and are grouped into two major variants: NAB2 exon 4-STAT6 exon 2/3 and NAB2 exon 5/6/7-STAT6 exon 16/17/18 based on clinicopathologic features [4][5][6]. SFTs with NAB2 exon 4-STAT6 exon 2/3 fusion variants are often located in the pleuropulmonary area and are less cellular with low mitotic activity and abundant background collagen.…”

Section: Introductionmentioning

confidence: 99%

“…SFTs with NAB2 exon 4-STAT6 exon 2/3 fusion variants are often located in the pleuropulmonary area and are less cellular with low mitotic activity and abundant background collagen. NAB2 exon 5/6/7-STAT6 exon 16/17/ 18 fusion variants on the other hand are associated with SFT development in the meninges and deep soft tissue and are associated with hypercellularity and recurrent tumors [4][5][6]. Both fusion variants have been reported in the meningeal SFTs [1].…”

Section: Introductionmentioning

confidence: 99%

Solitary Fibrous Tumor of the Central Nervous System: A Report of Two Cases with Emphasis on Diagnostic Pitfalls

Mwazha,

Moyeni,

Zikalala

et al. 2024

Case Reports in Pathology

View full text Add to dashboard Cite

Solitary fibrous tumor (SFT) is a rare primary central nervous system neoplasm that usually presents as a dural-based mass. Awareness of the entity is limited by the rarity of the tumor which renders it prone to misdiagnosis. We present two cases of SFT located in the right parafalx and intraventricular region. The cases were classified as WHO grade 1 and grade 2, respectively. The present study discusses the radiological, histomorphological, and immunohistochemical features of SFT, with emphasis on potential diagnostic pitfalls that may lead to erroneous diagnosis.

show abstract

Analysis of clinicopathological features and NAB2-STAT6 fusion variants of meningeal solitary fibrous tumor with ectopic salivary gland components in the cerebellopontine angle

Cited by 5 publications

References 49 publications

Oral solitary fibrous tumors: A collaborative clinicopathologic study of 19 cases

Oral solitary fibrous tumors: A collaborative clinicopathologic study of 19 cases

Solitary Fibrous Tumor of the Masticator Space withUnusual Extension: a Case Report

Solitary Fibrous Tumor of the Central Nervous System: A Report of Two Cases with Emphasis on Diagnostic Pitfalls

Contact Info

Product

Resources

About