Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood

Knez, Virginia; Bao, Liming; Carstens, Billie; Liang, Xiayuan

doi:10.1080/10428194.2020.1761970

Cited by 10 publications

(13 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23 Conversely, B-ALL/LBL is exceedingly rare in the oral cavity, although children and adolescents are frequently affected by this disease. 26 In our study, most individuals were in the seventh and sixth decades of life, in agreement with a multicentre study from Iran, in which most affected individuals were males in their 50s and 60s. 1 Nonetheless, individuals <60 years (53.6%) were slightly more affected than older adults, i.e., >60 years (46.4%).…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Arruda

Schuch

Neto

et al. 2021

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

“…In addition, it is well recognized that there is a high incidence of BL in childhood, particularly in the scenario of its endemic variant on the African continent 23 . Conversely, B‐ALL/LBL is exceedingly rare in the oral cavity, although children and adolescents are frequently affected by this disease 26 …”

Section: Discussionmentioning

confidence: 99%

Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Arruda

Schuch

Neto

et al. 2021

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Contrary to BCP-ALL, genetic mutations have not been extensively studied in children with BCP-LBL. However, candidate gene approach studies showed that several cytogenetic abnormalities seen in BCP-ALL occur in BCP-LBL as well, e.g., ETV6-RUNX1 fusions and a hyperdiploid karyotype [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Precursor B-Cell Lymphoblastic Malignancies: From Extramedullary to Medullary Involvement

Kroeze

Padilla

Bakker

et al. 2022

Cancers

View full text Add to dashboard Cite

B-cell lymphoblastic lymphoma (BCP-LBL) and B-cell acute lymphoblastic leukemia (BCP-ALL) are the malignant counterparts of immature B-cells. BCP-ALL is the most common hematological malignancy in childhood, while BCP-LBL accounts for only 1% of all hematological malignancies in children. Therefore, BCP-ALL has been well studied and treatment protocols have changed over the last decades, whereas treatment for BCP-LBL has stayed roughly the same. Clinical characteristics of 364 pediatric patients with precursor B-cell malignancies were studied, consisting of BCP-LBL (n = 210) and BCP-ALL (n = 154) patients. Our results indicate that based on the clinical presentation of disease, B-cell malignancies probably represent a spectrum ranging from complete isolated medullary disease to apparent complete extramedullary disease. Hepatosplenomegaly and peripheral blood involvement are the most important discriminators, as both seen in 80% and 95% of the BCP-ALL patients and in 2% of the BCP-LBL patients, respectively. In addition, we show that the overall survival rates in this cohort differ significantly between BCP-LBL and BCP-ALL patients aged 1–18 years (p = 0.0080), and that the outcome for infants (0–1 years) with BCP-LBL is significantly decreased compared to BCP-LBL patients of all other pediatric ages (p < 0.0001).

show abstract

“…For example, while favorable cytogenetics such as an ETV6–RUNX1 fusion or double trisomies of chromosomes 4 and 10 (DT) are associated with improved prognosis in B‐ALL, information in B‐LLy is sparse 21 . In a cytogenetic analysis of 18 B‐LLy specimens (compared to 126 B‐ALLs), the incidence of hyperdiploidy (>50 chromosomes) was comparable (13% in B‐ALL vs. 7% in B‐LLy; p = NS), but other recurrent abnormalities were more prevalent in B‐ALL (35% vs. 7% in B‐LLy; p = .0370) 22 . Meyer et al.…”

Section: Case 1: Newly Diagnosed B‐llymentioning

confidence: 99%

“…21 In a cytogenetic analysis of 18 B-LLy specimens (compared to 126 B-ALLs), the incidence of hyperdiploidy (>50 chromosomes) was comparable (13% in B-ALL vs. 7% in B-LLy; p = NS), but other recurrent abnormalities were more prevalent in B-ALL (35% vs. 7% in B-LLy; p = .0370). 22 Meyer et al conducted the largest molecular B-LLy analysis to date on 23 B-LLy compared to 50 B-ALL specimens. Their data revealed a comparable incidence of deletions in some B-cell-associated transcription factor genes including CDKN2A/B, IKZF1, and PAX5, but fewer deletions in ETV6 and EBF1.…”

Section: Distinguishing Featuresmentioning

confidence: 99%

How I approach B‐lymphoblastic lymphoma in children

Devine

Fries

Hermiston

et al. 2023

Pediatric Blood & Cancer

View full text Add to dashboard Cite

There are limited data pertaining to the prognostic features and optimal therapeutic approach for the 20%-25% of children with lymphoblastic lymphoma (LLy) who have the B-lymphoblastic subtype. Outcomes are favorable following treatment modeled after acute lymphoblastic leukemia (ALL) regimens, but prognosis is dismal after relapse, and there are no established features for predicting therapy response. Ongoing US and international trials will include the largest cohort of uniformly treated patients with B-LLy to date, providing an opportunity to define clinical and molecular predictors of relapse and to establish a standard of care for treatment to improve outcomes for this rare pediatric cancer.

show abstract

Analysis of clinicopathological and cytogenetic differences between B-lymphoblastic lymphoma and B-lymphoblastic leukemia in childhood

Cited by 10 publications

References 21 publications

Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Oral and oropharyngeal lymphomas: A multi‐institutional collaborative study

Pediatric Precursor B-Cell Lymphoblastic Malignancies: From Extramedullary to Medullary Involvement

How I approach B‐lymphoblastic lymphoma in children

Contact Info

Product

Resources

About