Analysis of clinical features, biochemical and inflammatory indexes in patients with acute pancreatitis

Abstract

Background: Acute pancreatitis (AP) is an inflammatory process unpredictability occurring in the pancreas, imposing a substantial burden on healthcare systems. Herein,Exploring the clinical characteristics of patients with acute pancreatitis, biochemical tests and the role of inflammatory indexes in the disease, to predict the prognosis of acute pancreatitis. Methods: We retrospectively analyzed the clinical data, biochemical and inflammatory indexes of 116 patients with acute pancreatitis diagnosed in Puren Hospital affiliated to Wuhan University of Science and Technology. They were divided into non-severe group and severe group. Counting data were expressed as rate (%), X2 test was used, and measurement data were expressed as mean±standard deviation. Comparison between the two groups was performed by t test, and comparison between the mean of more than two samples was performed by a one-way analysis of variance (ANOVA).P<0.05 was considered to be statistically significant.Receiver operating characteristic curve (ROC) analysis was performed according to the inflammatory indexes of the two groups, and the area under the curve (AUC) and the cut-off value (CUT-OFF) are calculated respectively. Results: The mean age of patients in the severe group was older, and the proportion of underlying diseases was higher. The biochemical and inflammatory indexes in the severe group were higher than those in the non-severe group (P < 0.05). The area under the curve (AUC) and CUT-OFF value (cut-off) were obtained by ROC curve analysis of the inflammatory indexes of white blood cell count (WBC), neutrophil count (NEUT), hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT) and interleukin-6 (IL-6). Conclusion: Elderly patients with acute pancreatitis accompanied by underlying diseases are more likely to develop into severe disease. In severe patients, biochemical tests are obviously abnormal and inflammatory indexes are increased or even excessive, which is helpful to judge the condition and prognosis of patients with acute pancreatitis.