Analysis of clinical course of severe acute biliary and non biliary pancreatitis: a comparative study

Kotán, Róbert; Pósán, János; Sápy, Péter; Damjanovich, László; Szentkereszty, Zsolt

doi:10.1556/oh.2010.28760

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…The reported mortality from SAP ranges from 9 to 27 percent. 1,2 The recovery depends on the nutritional reserves of the body, thus mandating the need for adequate nutritional supplement especially in patients of low socioeconomic country. TPN had been the standard nutritional management for many years for SAP.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome in low socioeconomic patients with severe acute pancreatitis treated either with early nasogastric tube or total parenteral nutrition: a randomized controlled trial

et al. 2019

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Background: Early nasogastric feeding has shown beneficial effect in the low socioeconomic group of patient with severe acute pancreatitis (SAP). The current randomized controlled study was performed to assess the effect of early nasogastric feeding as compared to total parenteral nutrition (TPN).Methods: Fifty patients admitted with diagnosis of SAP were randomly allocated to receive nnteral feeding (EF) (at the rate of 25 ml/hour and was gradually increased up to 100 ml/hr) or TPN within 24 hours of hospital admission. The nutritional regimen was aimed to be iso-caloric between the two groups. Patient’s demographics, hospital stay, nutrition, total cost, complication, and mortality were observed for 1 month in follow up.Results: All fifty patients were completed the study. Patient demographics were similar in both groups. 38/50 belonged to low socioeconomic status in the study group (Twenty in EF and eighteen in TPN group). The complications were significantly lower in EF group (pancreatic infection (11 vs. 4, p=0.037), central venous catheter infection (EF=0 vs. TPN=8, p=0.002), multiorgan failure (EF=5, TPN=12, p=0.037). Early recovery in EF group was significant with the mean duration of hospital stay of 6.76 days as compared to 10.4 days in the TPN group. The mean expenditure in the EF group was 1268 as compared to 13688 Indian rupees in the TPN group.Conclusions: This study shows that early EF improves early recovery, lower complications and cost effective measure in SAP especially in low socioeconomic group of patients.

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Section: Introductionmentioning

confidence: 99%

Clinical outcome in low socioeconomic patients with severe acute pancreatitis treated either with early nasogastric tube or total parenteral nutrition: a randomized controlled trial

et al. 2019

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“…As one of the most prevalent gastrointestinal disorders, the global burden of pancreatitis is very severe, with approximate 7 to 9 million patient leading to billions of US dollar's health care cost as well as 40% mortality in severe cases (5)(6)(7)(8)(9). However, pharmacological interventions to prevent the progression of pancreatitis are very limited.…”

Section: Discussionmentioning

confidence: 99%

“…In the United States, 299,150 hospital admissions are diagnosed with pancreatitis, incurring healthcare costs of approximate 8 billion US dollars in 2018 (6). The overall mortality rate for acute pancreatitis is reported to be around 20%, which rises sharply to 40% for severe cases (7)(8)(9). Severe acute pancreatitis can lead to complications such as sepsis or multiorgan failure (10).…”

Section: Introductionmentioning

confidence: 99%

Targeting ductal-endothelial crosstalk alleviate pancreatitis

Gao,

Ma,

Chen

et al. 2024

Preprint

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Pancreatitis are common gastrointestinal disorders that cause hospitalization with significant morbidity and mortality. The mechanistic pathophysiology of pancreatitis is complicated, which greatly limits the discovery of pharmacological intervention methods. Here, we show that administration of antagonist of Integrin-α5, significantly mitigates the pathological condition of acute pancreatitis. In caerulein-induced acute pancreatitis model, the newly emergent CK19 positive cells are highly vascularized with significant increase of vascular density and endothelial cell number. Single cell RNA sequencing analysis shows ductal and endothelial cells are intimate interacting partners. Pancreatitis dramatically reduce the crosstalk in ductal-endothelial interface but promote the integrin-α5 signaling. Blocking this signaling significantly reduce acinar-to-ductal metaplasia, pathological angiogenesis and restore other abnormal defects induced by caerulein. Our work reveals a therapeutic potential of targeting Integrin-α5 as uncharacterized pharmacological method to alleviate the symptom of pancreatitis.

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“…Acute pancreatitis is one of the most common gastrointestinal causes of hospitalization in the United States [1]. Various studies have reported high mortality rates of up to 21% [2,3]. With 618,862 new cases, India had the most number of incident cases in the world in 2019 [4].…”

Section: Introductionmentioning

confidence: 99%

Serum Lipase Amylase Ratio as an Indicator to Differentiate Alcoholic From Non-alcoholic Acute Pancreatitis: A Systematic Review and Meta-Analysis

Ekka¹,

Kujur²,

Guria³

et al. 2023

Cureus

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A lipase/amylase (L/A) ratio of more than three may be a tool for differentiating alcoholic pancreatitis from non-alcoholic pancreatitis. We conducted a systematic literature review to identify published studies. A thorough data search of various databases was conducted using keywords. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 survey. Data were extracted under the following headings: country, sample size, baseline characteristics, specificity, and sensitivity of the L/A ratio. Studies were analyzed using a bivariate random-effects model, and the sensitivity and specificity of the L/A ratio were pooled separately. Summary receiver operating characteristic (SROC) curves were plotted using the hierarchical method. A total of nine studies with 1,825 patients were identified for inclusion. SROC showed estimates of the area under the curve to be 0.75 (confidence interval (CI) = 0.71-0.79). Forest plots for sensitivity and specificity showed pooled estimates of sensitivity to be 74% (95% CI = 62-83%) while that of specificity was 63% (95% CI = 47-77%). The pooled diagnostic odds ratio was estimated to be 5 (95% CI = 3-9), the pooled positive likelihood ratio was estimated at 2.0, and the pooled negative likelihood ratio was estimated to be 0.41. We concluded that an L/A ratio of more than 3 has moderate accuracy for the diagnosis of alcoholic pancreatitis.

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Analysis of clinical course of severe acute biliary and non biliary pancreatitis: a comparative study

Abstract: Female patients suffering from severe biliary acute pancreatitis have higher morbidity and mortality rate. Therefore an elective cholecystectomy is suggested in old female patients with serious co-morbidity and gallstones, before any complications.

Cited by 5 publications

References 20 publications

Clinical outcome in low socioeconomic patients with severe acute pancreatitis treated either with early nasogastric tube or total parenteral nutrition: a randomized controlled trial

Clinical outcome in low socioeconomic patients with severe acute pancreatitis treated either with early nasogastric tube or total parenteral nutrition: a randomized controlled trial

Targeting ductal-endothelial crosstalk alleviate pancreatitis

Serum Lipase Amylase Ratio as an Indicator to Differentiate Alcoholic From Non-alcoholic Acute Pancreatitis: A Systematic Review and Meta-Analysis

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