Analysis of Chlorpheniramine Maleate in Microcapsules Formulation with Eudragit E PO Polymer using Spray Drying Method

Abstract

Research on the analysis of chlorpheniramine maleate (CTM) in microcapsules formulation with eudragit E PO polymer using the spray drying method had been carried out. The study aims to cover the bitter taste of the drug and know the encapsulation efficiency of several formulas by calculating the drug content in them. The formulations were made with the ratio of CTM and eudragit E PO, namely 1:1, 1:2, and 1:3. The evaluation of the microcapsules included the shape and morphology of the particles using a Scanning Electron Microscope (SEM), particle size distribution, infrared spectroscopy, encapsulation efficiency, and leak tests. The results showed that the microcapsules obtained had irregular shapes and morphology in the three formulas. The average particle size distribution of microcapsules ranged from 60-200μm. The results of infrared spectroscopy analysis showed that there was no interaction between the active substance, polymer, and additives, with no new peak formation. The result of the greatest encapsulation efficiency was found in formula 3 (1:3), which was 95%. The results of the leak test on formula 1, formula 2, and formula 3 were 91.57%, 74%, and 67.72%, respectively. The results of the leak test were expected to be negative, but there were leaks in the three formulas. It can be concluded that the CTM-eudragit E PO microcapsules using the spray drying method using an inlet temperature of 80ºC, an outlet temperature of 60ºC, a spraying speed of 3 mL/min, and a nozzle of 30 μm were not very effective.