Analysis of Chinese Medicine Compound in Treatment of Urticaria with Rheumatic Fever

Abstract

Purpose: To explore the rules of prescriptions of modern clinical Chinese medicine compound prescriptions in treatment of urticaria with rheumatic fever, and to provide a reference for the clinical treatment. Methods: The literature on the treatment of urticaria with rheumatic fever with medicine compound prescriptions from October 1st, 1949 to January 1st, 2021 in China National Knowledge Infrastructure (CNKI) was searched to establish an Excel database of medicine prescriptions, and data analysis was performed by SPSS Statistics22.0 and SPSS Modeler18.0. Results: A total of 52 articles are included in this study, involving 54 medicine prescriptions and 97 Chinese medicines with a cumulative frequency of 623 times. Among them, 39 Chinese medicines are used more than 4 times, with the highest frequency of Fangfeng. They are mainly pungent, cold in nature, with the channel tropism of liver and lung. There are 19 second-order association rules for mining TCM association rules, with the first five rules ranked in the descending order of confidence as follows: Fangfeng + Scutellaria baicalensis, Jingjie + Anemarrhenae Rhizoma, Fangfeng + Anemarrhenae rhizoma, Fangfeng + Arctium fruit, Fangfeng + Jingjie, with 103 third-order associations and 124 fourth-order associations, which are consistent with the actual clinical application. Conclusion: The modern clinical treatment of urticaria with rheumatic fever is based on "dispelling wind to relieve exterior syndrome", and also on "curing deficiency", "resolving dampness", "suppressing hyperactive liver for calming endogenous wind", and "promoting blood circulation and removing blood stasis". The data provides reference for the clinical treatment of the disease and Chinese medicine research.