Analysis of chest computed tomography manifestations of non- Mycobacterium tuberculosis induced granulomatous lung diseases

Zhu, Qiao; Xu, X N; Li, Meijiao; Wang, Xiaohua

doi:10.1016/j.jrid.2017.10.001

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…In most studies, non-infectious GLD are the most prevalent among patients submitted to lung biopsy [ 1 , 13 ]. This difference is probably due to the high prevalence of fungal diseases, such as histoplasmosis and tuberculosis in our population.…”

Section: Discussionmentioning

confidence: 99%

“…Among the patients with biopsy proven granulomatous disease, as in the studies of Sakakibara et al [ 15 ] and Zhu et al [ 1 ], the most commonly found radiological pattern was solitary pulmonary nodule, which can be explained by the crescent indication of lung biopsies for investigation of indeterminate solitary pulmonary nodules suspected for malignancy [ 16 ]. This pattern was significantly associated with histoplasmosis (p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Granulomatous Lung Diseases (GLD) encompasses a wide range of infectious and non-infectious conditions characterized by chronic inflammatory response [ 1 ]. Generally, the etiology is defined combining clinical symptoms, laboratorial findings, and imaging features.…”

Section: Introductionmentioning

confidence: 99%

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Etiological profile and main imaging findings in patients with granulomatous diseases who underwent lung biopsy

Oliveira

Horvat

Testagrossa

et al. 2021

European Journal of Radiology Open

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Background: Granulomatous Lung Diseases (GLD) encompasses a wide range of infectious and non-infectious conditions characterized by chronic inflammatory response. However, different GLD may share similar imaging findings. In this context, the purpose of this study was to outline the etiological profile and their imaging features in patients with GLD who underwent lung biopsy. Methods: Patients with granulomatous lesions in lung biopsies and previous chest CT performed from 2014 to 2017 at our institution had imaging data reviewed by three blinded radiologists. The imaging features were analyzed according to the Fleischner Society glossary. Categorical data were represented by absolute (n) and relative (%) frequency. The contingency matrices were analyzed by Pearson's Chi-square test. Interreader agreement was assessed by calculating the intraclass correlation coefficient, using kappa (κ) statistic. Results: Thirty-eight of 75 (50.7%) patients were women with a mean age of 59 ± 39 years. Infection was the most common cause of GLD (47/75, 62.7%) and Histoplasma capsulatum (27/75, 36%) was the most prevalent etiology. Nodular pattern was the most common imaging feature in histoplasmosis cases (25/27, 92.6%), whereas it occurred in half of cases (24/48) of GLD of other causes (p < 0.05). Among patients with tuberculosis, the second etiology of GLD in our study population, the most common imaging pattern was centrilobular micronodules (3/7, 42.9%), significantly more frequent than in other causes of GLD (6/68, 8.8%). Interreader agreement in detecting imaging features was almost perfect (κ = 0.88-1.00), except the nodular pattern, which had substantial agreement (κ = 0.73). Conclusions: In our study population, the main etiologies found in patients with granulomatous disease who underwent lung biopsy were fungal or mycobacterial disease, specially histoplasmosis and tuberculosis, and nodular pattern with focal distribution was the most common imaging finding which was detected with substantial interreader agreement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Etiological profile and main imaging findings in patients with granulomatous diseases who underwent lung biopsy

Oliveira

Horvat

Testagrossa

et al. 2021

European Journal of Radiology Open

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The diagnosis and management of pulmonary actinomycosis

Boot¹,

Archer²,

Ali³

2023

Journal of Infection and Public Health

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Centri-lobular pulmonary nodules on HRCT: incidence and approach for etiological diagnosis

Hafez

Koirala

Hinnawy

et al. 2022

Egypt J Radiol Nucl Med

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Background Centri-lobular nodules are the most common pattern of diffuse pulmonary nodules encountered on high-resolution computed tomography (HRCT). HRCT with post-processing techniques such as obtaining maximum intensity projection (MIP) is helpful in making centri-lobular nodules more conspicuous. The study aimed to highlight the role of HRCT with its reconstruction capabilities in the detection and characterization of centri-lobular pulmonary nodules, interpret the most frequent associated findings, and correlate with the clinical findings to reach the most appropriate diagnosis. Results The study included 58 patients; 41.4% males and 58.6% females. Their age ranged from 2 to 67 years with mean age of 25.69. The centri-lobular nodules numbers, distribution, shape, and associated HRCT chest findings were identified. The top three etiological diagnoses were infection/inflammation in 50.0% of cases followed by acute viral bronchiolitis in 27.6% and inhalation bronchiolitis in 19.0% of cases. Correlation of HRCT findings with the clinical diagnosis was carried out with consequent formulation of an algorithm for the diagnostic approach of various etiologies of centri-lobular pulmonary nodules. Conclusions HRCT is a useful tool in the detection and characterization of centri-lobular pulmonary nodules. It can be used to differentiate the different etiologies that share centri-lobular nodularity. Other associated features and multidisciplinary approach are essential for further characterization of the most relevant etiological diagnosis.

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Analysis of chest computed tomography manifestations of non- Mycobacterium tuberculosis induced granulomatous lung diseases

Cited by 3 publications

References 15 publications

Etiological profile and main imaging findings in patients with granulomatous diseases who underwent lung biopsy

Etiological profile and main imaging findings in patients with granulomatous diseases who underwent lung biopsy

The diagnosis and management of pulmonary actinomycosis

Centri-lobular pulmonary nodules on HRCT: incidence and approach for etiological diagnosis

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