Analysis of chemical warfare agents in organic liquid samples with magnetic dispersive solid phase extraction and gas chromatography mass spectrometry for verification of the chemical weapons convention

Singh, Varoon; Purohit, Ajay Kumar; Chinthakindi, Sridhar; Goud, Raghavender D.; Tak, Vijay; Pardasani, Deepak; Shrivastava, Anchal Roy; Dubey, D. K.

doi:10.1016/j.chroma.2016.04.058

Cited by 15 publications

(4 citation statements)

References 24 publications

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“…The Temkin isotherm is used to determine the heat of absorption, which can describe the adsorption process. A positive B value indicates an exothermic process and based on the Temkin adsorption parameter calculation, all adsorbents have a positive B value; hence, the adsorption process that occurred was exothermic [39][40][41].…”

Section: Isotherm Adsorption Evaluationmentioning

confidence: 99%

“…The model representing the adsorption isotherm of an adsorbent needs to have an R 2 value greater than 0.95. According to the values of R 2 Freundlich (chemical adsorption), the adsorption isotherm model was the most suitable to describe MIP [39][40][41]. Meanwhile, the Langmuir isotherm model was most suitable to describe the NIP adsorption and showed that the interaction between andrographolide and NIP was physical adsorption.…”

Section: Isotherm Adsorption Evaluationmentioning

confidence: 99%

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Purification of Andrographolide Methanolic Extract Using Molecularly Imprinted Polymer Prepared by Precipitation Polymerization

2022

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Molecularly Imprinted Polymer (MIP) has a specific cavity in which the conformity of shape, size, and functionalities corresponds with its template molecule and has been widely used in separation processes. Therefore, this study aims to examine the application of MIP for the purification of andrographolide. The MIP was synthesized by precipitation polymerization using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA) as the functional monomer and cross-linker, andrographolide as a template, and acetonitrile:toluene (3:1) as porogen solvent. The results showed that the binding capacity of Synthesized MIP was 1.2486 mg/g, while the particle size was 295.5 nm with a polydispersity index of 0.064. Furthermore, the imprinting and selectivity factors were 1.148 and 12.37, respectively. The purification process by MIP increased the purity from 55.37 ± 0.69 to 94.94% ± 0.34, while the isolate characterization showed that purified andrographolide had a similar character compared to the standard.

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Section: Isotherm Adsorption Evaluationmentioning

confidence: 99%

Section: Isotherm Adsorption Evaluationmentioning

confidence: 99%

Purification of Andrographolide Methanolic Extract Using Molecularly Imprinted Polymer Prepared by Precipitation Polymerization

2022

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“…Recently, magnetic dispersive solid phase extraction (M-DSPE) has received attention because of its properties such as magnetic recovery capability, ease of operation, high performance, the suitability to preconcentration of the analyte from voluminosity samples, and optional functionalization of materials. 19–22…”

Section: Introductionmentioning

confidence: 99%

Magnetic activated carbon as an adsorbent for extraction of DMMP from aqueous samples followed by GC-IMS analysis

Farahani,

Najafi,

Behbahani

et al. 2023

Anal. Methods

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“…Because some environmental matrices are complex and cannot be directly introduced to instrumental analysis, sample preparation methods are key for the successful confirmation of CWAs and are very important for the selective removal of interferences, including complex hydrocarbon content. These methods may include concentration, dilution, solvent exchange, LLE, solid phase extraction (SPE), and magnetic dispersive solid phase extraction (MDSPE) …”

Section: Introductionmentioning

confidence: 99%

Identification of G‐nerve agents at picogram levels from complex organic samples containing hydrocarbon interferences by aqueous extraction, followed by derivatization and liquid chromatography‐mass spectrometry analysis

et al. 2019

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The chromatograms obtained from the gas chromatography-electron ionization mass spectrometric (GC-EI-MS) analysis of extracts containing G-nerve agents in the presence of diesel, gasoline, etc., are dominated by hydrocarbon backgrounds that "mask" the G-nerve agents, leading to severe difficulties in identification. This paper presents a practical solution for this challenge by transferring the G-nerve agents from the organic phase into the aqueous phase using liquid-liquid extraction (LLE), followed by derivatization with 2-[(dimethylamino)methyl]phenol (2-DMAMP), allowing ultrasensitive LC-ESI-MS/MS analysis of the G-derivatives. The proposed approach enables rapid identification of trace amounts of G-nerve agents with limits of identification (LOIs) at the pg/mL scale.

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Analysis of chemical warfare agents in organic liquid samples with magnetic dispersive solid phase extraction and gas chromatography mass spectrometry for verification of the chemical weapons convention

Cited by 15 publications

References 24 publications

Purification of Andrographolide Methanolic Extract Using Molecularly Imprinted Polymer Prepared by Precipitation Polymerization

Purification of Andrographolide Methanolic Extract Using Molecularly Imprinted Polymer Prepared by Precipitation Polymerization

Magnetic activated carbon as an adsorbent for extraction of DMMP from aqueous samples followed by GC-IMS analysis

Identification of G‐nerve agents at picogram levels from complex organic samples containing hydrocarbon interferences by aqueous extraction, followed by derivatization and liquid chromatography‐mass spectrometry analysis

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