Analysis of Cerebral Aneurysms using Computational Fluid Dynamics (CFD)(&lt;SPECIAL ISSUE&gt;New Concept in Treatment for Cerebral Aneurysm)

洋之, 高尾; 誠, 山本; 忍, 大塚; 貴士, 鈴木; 俊輔, 増田; 雄一, 村山; 俊昭, 阿部

doi:10.7887/jcns.21.298

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…The order of difference in values is up to 20 pa in some regions, as shown in figures 4-c and 5-c. The aneurysmal WSS is a main factor that affects the rapture of cerebral aneurysms [15]. Moreover, severe WSS gradients associated with disturbed flow, effects on the internal elastic lamina of vessels and helps the formation and growth of a cerebral aneurysm [2,9,16].…”

Section: Discussionmentioning

confidence: 99%

Effects of Non-Newtonian Viscosity on the Hemodynamics of Cerebral Aneurysms

Gibaly¹,

El-Bassiouny²,

Diaa³

et al. 2016

AMM

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The purpose of this study is to present a comparative study between Newtonian and non-Newtonian blood viscosity models for simulating the hemodynamic wall shear stress (WSS) of cerebral aneurysms. The non-Newtonian blood viscosity was modeled using the Carreau-Yasuda nonlinear model. Two realistic cerebral aneurysm models, derived from 3D angiography imaging, were studied and simulated via computational fluid dynamics solver based on finite volume method, with a pulsating sinusoidal waveform boundary conditions. The maximum wall shear stresses were found at the aneurysm’s neck and apex, the inlet arteriole recorded an average wall shear stress and as for the blebs and tips the wall shear stress values were remarkably low. The comparison indicated that non-Newtonian blood viscosity model predicted a lower range of WSS than of the Newtonian model, which provides more accuracy for simulating aneurysm hemodynamics.

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Section: Discussionmentioning

confidence: 99%

Effects of Non-Newtonian Viscosity on the Hemodynamics of Cerebral Aneurysms

Gibaly¹,

El-Bassiouny²,

Diaa³

et al. 2016

AMM

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show abstract

“…The simulations were conducted at Re = 100, 400 and 600 which represent the physiological range of Re in the cerebral arteries [64,65]. The Reynolds number is calculated based on (6) for the Newtonian viscosity model and ( 7) for the non-Newtonian viscosity model [66,67]. Table 1 provides a summary for the corresponding mean velocity at different Reynolds number for the Newtonian and non-Newtonian viscosity models.…”

Section: Plos Onementioning

confidence: 99%

“…Intracranial aneurysm (IA) is considered among the most dangerous vascular disorders that cause millions of deaths every year all over the world [ 2 , 3 ]. Intracranial aneurysm, is a cerebrovascular lesion in which, the weak area of the blood vessel usually enlarges [ 2 , 4 – 6 ]. It is a bulging that protrudes when the blood vessel wall becomes excessively weak to withstand the hemodynamic forces [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Numerical study on the energy cascade of pulsatile Newtonian and power-law flow models in an ICA bifurcation

2021

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The complex physics and biology underlying intracranial hemodynamics are yet to be fully revealed. A fully resolved direct numerical simulation (DNS) study has been performed to identify the intrinsic flow dynamics in an idealized carotid bifurcation model. To shed the light on the significance of considering blood shear-thinning properties, the power-law model is compared to the commonly used Newtonian viscosity hypothesis. We scrutinize the kinetic energy cascade (KEC) rates in the Fourier domain and the vortex structure of both fluid models and examine the impact of the power-law viscosity model. The flow intrinsically contains coherent structures which has frequencies corresponding to the boundary frequency, which could be associated with the regulation of endothelial cells. From the proposed comparative study, it is found that KEC rates and the vortex-identification are significantly influenced by the shear-thinning blood properties. Conclusively, from the obtained results, it is found that neglecting the non-Newtonian behavior could lead to underestimation of the hemodynamic parameters at low Reynolds number and overestimation of the hemodynamic parameters by increasing the Reynolds number. In addition, we provide physical insight and discussion onto the hemodynamics associated with endothelial dysfunction which plays significant role in the pathogenesis of intracranial aneurysms.

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Relationship Between Coronary Fractional Flow Reserve and Computational Fluid Dynamics Analysis in Moderate Stenosis of the Coronary Artery

et al. 2020

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Background: Fractional flow reserve (FFR) is used to evaluate the need for percutaneous coronary intervention (PCI) in cases of moderate stenosis of the coronary artery. Recently, diagnostic imaging support with computational fluid dynamics (CFD) analysis has been garnering attention. This study defines the relationship between FFR conducted for cardiac catheterization and CFD analyses conducted using coronary computed tomography (CT) for moderate stenosis, in addition to considering whether wall pressure (WP) and wall shear stress (WSS) can be used to evaluate ischemia. Methods and Results: Cases in which FFR was measured via coronary CT and cardiac catheterization was performed within 3 months were collected retrospectively. In the CFD analysis, WP and WSS were calculated and compared with FFR. Three groups were created to compare results of CFD analysis and FFR values according to the location of the stenosis: the right coronary artery, the left anterior descending artery, and the left circumflex artery. There was a correlation between FFR and WSS according to CFD analysis for moderate stenosis of the coronary artery, with a cutoff value for treatment able to be calculated. Conclusions: The results of this study suggest that ischemia can be evaluated by conducting CFD analysis (WSS) using coronary CT.

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Analysis of Cerebral Aneurysms using Computational Fluid Dynamics (CFD)(<SPECIAL ISSUE>New Concept in Treatment for Cerebral Aneurysm)

Abstract: on the role of WSS is cerebral aneurysm dynamics ． ID this paper ， we report the results of CFD analysis on cerebral aneurysms and we compare our results to other recent papers in the field ．（

Cited by 3 publications

References 24 publications

Effects of Non-Newtonian Viscosity on the Hemodynamics of Cerebral Aneurysms

Effects of Non-Newtonian Viscosity on the Hemodynamics of Cerebral Aneurysms

Numerical study on the energy cascade of pulsatile Newtonian and power-law flow models in an ICA bifurcation

Relationship Between Coronary Fractional Flow Reserve and Computational Fluid Dynamics Analysis in Moderate Stenosis of the Coronary Artery

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Analysis of Cerebral Aneurysms using Computational Fluid Dynamics (CFD)(<SPECIAL ISSUE>New Concept in Treatment for Cerebral Aneurysm)

Abstract: on the role of WSS is cerebral aneurysm dynamics ． ID this paper ， we report the results of CFD analysis on cerebral aneurysms and we compare our results to other recent papers in the field ． （

Cited by 3 publications

References 24 publications

Effects of Non-Newtonian Viscosity on the Hemodynamics of Cerebral Aneurysms

Effects of Non-Newtonian Viscosity on the Hemodynamics of Cerebral Aneurysms

Numerical study on the energy cascade of pulsatile Newtonian and power-law flow models in an ICA bifurcation

Relationship Between Coronary Fractional Flow Reserve and Computational Fluid Dynamics Analysis in Moderate Stenosis of the Coronary Artery

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Resources

About

Abstract: on the role of WSS is cerebral aneurysm dynamics ． ID this paper ， we report the results of CFD analysis on cerebral aneurysms and we compare our results to other recent papers in the field ．（