Analysis of Cerebral Aneurysm Wall Tension and Enhancement Using Finite Element Analysis and High-Resolution Vessel Wall Imaging

Galloy, Adam; Raghuram, Ashrita; Nino, Marco A.; Miller, Alberto Varon; Sabotin, Ryan; Osorno‐Cruz, Carlos; Samaniego, Edgar A; Raghavan, Suresh M. L.; Hasan, David

doi:10.3389/fneur.2021.764063

Cited by 4 publications

(1 citation statement)

References 42 publications

(47 reference statements)

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“…For the same material, the deformation of the three-layer membrane and single-layer membrane structure CA models was basically the same, and the displacement deformation of both membrane structures differed by about 1%. For the same structure, the deformation of the linear elastic material model is larger than that of the hyperelastic material, which is consistent with the results of Galloy et al (2021) . In addition, the calculations showed that the maximum displacements occurred in the intima.…”

Section: Discussionsupporting

confidence: 88%

The biomechanical effects of different membrane layer structures and material constitutive modeling on patient-specific cerebral aneurysms

Fan,

Zhang,

Zheng

et al. 2024

Front. Bioeng. Biotechnol.

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The prevention, control and treatment of cerebral aneurysm (CA) has become a common concern of human society, and by simulating the biomechanical environment of CA using finite element analysis (FEA), the risk of aneurysm rupture can be predicted and evaluated. The target models of the current study are mainly idealized single-layer linear elastic cerebral aneurysm models, which do not take into account the effects of the vessel wall structure, material constitution, and structure of the real CA model on the mechanical parameters. This study proposes a reconstruction method for patient-specific trilaminar CA structural modeling. Using two-way fluid-structure interaction (FSI), we comparatively analyzed the effects of the differences between linear and hyperelastic materials and three-layer and single-layer membrane structures on various hemodynamic parameters of the CA model. It was found that the numerical effects of the different CA membrane structures and material constitution on the stresses and wall deformations were obvious, but does not affect the change in its distribution pattern and had little effect on the blood flow patterns. For the same material constitution, the stress of the three-layer membrane structure were more than 10.1% larger than that of the single-layer membrane structure. For the same membrane structure, the stress of the hyperelastic material were more than 5.4% larger than that of the linear elastic material, and the displacement of the hyperelastic material is smaller than that of the linear elastic material by about 20%. And the maximum value of stress occurred in the media, and the maximum displacement occurred in the intima. In addition, the upper region of the tumor is the maximum rupture risk region for CA, and the neck of the tumor and the bifurcation of the artery are also the sub-rupture risk regions to focus on. This study can provide data support for the selection of model materials for CA simulation and analysis, as well as a theoretical basis for clinical studies and subsequent research methods.

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Section: Discussionsupporting

confidence: 88%