Analysis of Carcinogenic Heavy Metals in Gallstones and its Role in Gallbladder Carcinogenesis

Mondal, B.; Maulik, Dhrubajyoti; Mandal, Mousumi; Sarkar, Gautam Narayan; Sengupta, Sanjay; Ghosh, Debidas

doi:10.1007/s12029-016-9898-1

Cited by 20 publications

(32 citation statements)

References 24 publications

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“…Statistically higher concentrations of cadmium, along with other heavy metals, were observed [47]. Although a causal link involving cadmium was not observed, it does suggest a potential role in malignant growth of the bladder [47]. Cadmium has also demonstrated carcinogenic activity on liver cells in a laboratory setting [44].…”

Section: Cadmiummentioning

confidence: 98%

“…Cadmium also has a proposed role in the development of cancer in the gallbladder. The composition of gallstones, which are recognized as a risk factor for carcinogenesis, were analyzed from patients with this type of cancer [47]. Statistically higher concentrations of cadmium, along with other heavy metals, were observed [47].…”

Section: Cadmiummentioning

confidence: 99%

“…The composition of gallstones, which are recognized as a risk factor for carcinogenesis, were analyzed from patients with this type of cancer [47]. Statistically higher concentrations of cadmium, along with other heavy metals, were observed [47]. Although a causal link involving cadmium was not observed, it does suggest a potential role in malignant growth of the bladder [47].…”

Section: Cadmiummentioning

confidence: 99%

“…Another study concluded that patients with higher levels of blood lead had an increased risk of developing renal cell carcinoma [60]. Lead was one of several heavy metals observed in statistically higher concentrations in gallstones [47]. This suggests exposure to this metal represents an increased risk of malignant growth in the gallbladder [47].…”

Section: Leadmentioning

confidence: 99%

“…Lead was one of several heavy metals observed in statistically higher concentrations in gallstones [47]. This suggests exposure to this metal represents an increased risk of malignant growth in the gallbladder [47]. In a study performed on lead exposed workers, positive correlation was observed between exposure to this heavy metal and increased risk of carcinogenesis in lung tissue and marginal positive correlation for malignant growth in brain, larynx and bladder tissues [62].…”

Section: Leadmentioning

confidence: 99%

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Heavy Metals and Cancer

Carver¹,

Gallicchio²

2018

Cancer Causing Substances

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There has been increased concern surrounding exposure to heavy metals due to the evolving understanding of their role in the development of cancer. This review highlights research related to the impact that heavy metals aluminum, arsenic, beryllium, cadmium, lead, mercury, nickel and radium have on human health. Research was collected through PubMed, and it was compiled to assess the current knowledge of exposure sources, types of cancers induced and therapeutic measures for these metals. Furthermore, it was designed to assist in guiding future research efforts with respect to heavy metals and cancer.

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Section: Cadmiummentioning

confidence: 98%

Section: Cadmiummentioning

confidence: 99%

Section: Cadmiummentioning

confidence: 99%

Section: Leadmentioning

confidence: 99%

Section: Leadmentioning

confidence: 99%

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Heavy Metals and Cancer

Carver¹,

Gallicchio²

2018

Cancer Causing Substances

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Potential hazards of fenvalerate in massive pollution influence the apoptosis sensitivity

Cui

Jin

Sun

et al. 2017

J of Applied Toxicology

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Fenvalerate (Fen), a synthetic pyrethroid insecticide, is widely used in agricultural, domestic and veterinary applications. Fen induces abnormal cell proliferation and apoptosis, which are linked to its hazardous effects. However, this view is controversial and the underlying molecular mechanisms remain elusive. In the present study, the effects of Fen on cadmium (Cd)-induced apoptosis and the associated molecular mechanisms were investigated in human myeloid leukemia U937 cells. U937 cells were treated with 50 μm cadmium chloride (CdCl ) with or without Fen pretreatment at 1-50 μm. Apoptosis was evaluated by externalization of phosphatidylserine on the plasma membrane. The expression levels of apoptosis-related proteins, including Bcl-2 family members were determined by western blot analysis. The results revealed that pretreatment with Fen at 20 μm for 12 hours significantly inhibited Cd-induced apoptosis. Decreased expression of pro-apoptotic Bcl-2 family proteins (Noxa and Bid) and increased expression of anti-apoptotic proteins (Bcl-xL, Mcl-1 and XIAP) were observed after combined treatment with Fen and CdCl . Phosphorylation of ERK and AKT was increased, while phosphorylation of JNK was decreased by the combined treatment, compared with CdCl treatment alone. In conclusion, Fen decreased apoptotic sensitivity induced by Cd in U937 cells. This effect was associated with activation of ERK and AKT, suppression of JNK and changes in expression of Bcl-2 family proteins and XIAP. The present findings suggest a potential influence of Fen on Cd toxicity via suppression of apoptosis. Fen decreased apoptotic sensitivity induced by Cd, and thus it may contribute carcinogenic risk and influence on cancer therapy.

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Arsenic's shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer

Elgenidy,

Odat,

Al‐Ghorbany

et al. 2024

J Hepato Biliary Pancreat

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IntroductionGallbladder carcinoma (GBC) and cholangiocarcinoma are aggressive forms of cancer developed in the gallbladder and biliary tracts which are related to the liver. This systematic review aimed to highlight the significant association between gallbladder, biliary cancers, and arsenic exposure.MethodsAn extensive search was conducted in Embase, Cochrane, Scopus, PubMed, and Web of Science. We included studies that assessed arsenic levels in gallbladder cancer patients, without restrictions on age, sex, or language. Biological samples, such blood, bile, gallbladder tissue, gallstones, and hair were obtained, and arsenic levels were measured. Also, arsenic water and soil concentrations were collected.ResultsA total of 13 studies were included in our review. These studies included 2234 non‐gallbladder carcinoma patients and 22 585 gallbladder carcinoma cases. The participant demographics showed a gender distribution of 862 males and 1845 females, with an age range of 20–75 years. The average body mass index (BMI) was 19.8 kg/m2 for nongallbladder carcinoma patients and 20.1 kg/m2 for gallbladder carcinoma cases. The selected studies examined arsenic concentrations across various biological samples, including blood, hair, gallstones, and bile. Blood arsenic levels ranged from 0.0002 to 0.3893 μg/g and were significantly associated with increased gallbladder carcinoma risk in several studies. Hair also demonstrated a significant correlation, with arsenic concentrations ranging from 0.0002 to 6.9801 μg/g.ConclusionThere is a strong link between arsenic exposure and gallbladder cancer or cholangiocarcinoma. Even chronic exposure to low‐moderate amounts could lead to gallbladder carcinoma. These findings stress the need for more comprehensive and dedicated studies, to control arsenic water/soil levels and seek other preventive measures for this high mortality disease.

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Analysis of Carcinogenic Heavy Metals in Gallstones and its Role in Gallbladder Carcinogenesis

Cited by 20 publications

References 24 publications

Heavy Metals and Cancer

Heavy Metals and Cancer

Potential hazards of fenvalerate in massive pollution influence the apoptosis sensitivity

Arsenic's shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer

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