Analysis of Captan on Nitrile Glove Surfaces Using a Portable Attenuated Total Reflection Fourier Transform Infrared Spectrometer

Abstract

This study developed a method to produce uniform captan surface films on a disposable nitrile glove for quantitation with a portable attenuated total reflection Fourier transform infrared (ATR-FTIR) spectrometer. A permeation test was performed using aqueous captan formulation. Uniform captan surface films were produced using solvent casting with 2-propanol and a 25 mm filter holder connected to a vacuum manifold to control solvent evaporation. The coefficient of variation of the reflectance at 1735 +/- 5 cm(-1) was minimized by selection of the optimum solvent volume, airflow rate, and evaporation time. At room temperature, the lower to upper quantifiable limits were 0.31-20.7 microg/cm2 (r = 0.9967; p < or = 0.05) for the outer glove surface and 0.55-17.5 microg/cm2 (r = 0.9409; p < or = 0.05) for the inner surface. Relative humidity and temperature did not affect the uncoated gloves at the wavelength of captan analysis. Glove screening using ATR-FTIR was necessary as a control for between-glove variation. Captan permeation, after 8 hours exposure to an aqueous concentration of 217 mg/mL of Captan 50-WP, was detected at 0.8 +/- 0.3 microg/cm2 on the inner glove surface. ATR-FTIR can detect captan permeation and can determine the protectiveness of this glove in the field.

Permeation of a straight oil metalworking fluid through a disposable and a chemically protective nitrile glove

“…The chemically protective unsupported/unlined nitrile glove was Sol-Vex (catalog number 37-145, Ansell, Coshocton, OH). These two gloves have reliable quality and have been tested extensively by our research group [12][13][14][15][16]18]. …”

Variability in Surface Infrared Reflectance of Thirteen Nitrile Rubber Gloves at Key Wavelengths for Analysis of Captan

“…To control for within-glove variation the use of paired measurements is still recommended if out-of-box within-glove CVs are greater than 10%. 7 Between-lot variation at 1735 cm À1 was statistically significant (p 0.05) for all lots tested, except for the SafeSkin lots 1 and 2 (Fig. 6).…”

“…Prior ATR-FT-IR work on pesticides has been essentially qualitative, 2,3 except for recent work by Carden et al 6 and this research group. 7 Carden et al 6 used ATR-FT-IR to measure the pesticides azinphos-methyl and captan on skin surfaces, but complex multivariate analysis methods were needed for quantification due to skin variation. Similar spectral variation with CPC has not been examined and needs to be investigated, one of the objectives of the present study.…”