Analysis of Brain Activity Changes in Patients with Parkinson’s Disease Based on Resting-State Functional Magnetic Resonance Imaging

Abstract

This paper uses resting-state functional magnetic resonance imaging to observe the changes in local consistency of brain activity in patients with Parkinson’s disease (PD). Both healthy volunteers and Parkinson’s disease patients were scanned for resting brain functional imaging, and the collected raw data were processed using resting functional magnetic resonance data processing toolkit software. This study adopted the use of Regional Homogeneity (ReHo). The postprocessing method of RS-fMRI is to study the spontaneous brain activity changes of patients with Parkinson’s disease and cognitive impairment and to explore the changes in the function of their brain regions in the hope of providing help for the treatment of Parkinson’s disease cognitive impairment. The results showed that, compared with the normal control group, the brain regions with increased ReHo values in the PD group were the right central anterior gyrus, the right lingual gyrus, the left middle occipital gyrus, and the bilateral anterior cuneiform lobes. The results show that PD patients have abnormal brain nerve activities in the resting state, and these abnormal brain nerve activities may be related to PD cognitive and behavioral dysfunction.

Left middle frontal gyrus (MFG) thickness in Parkinson’s disease patients is associated with abnormal audiovisual conflict

“…This was consistent with previous findings that the degeneration of brain neurons in PD patients led to extensive cortical thickness thinning of the cerebral cortex (Laansma et al, 2021;Sarasso et al, 2021), such as the temporal, frontal, and parietal regions (Tang et al, 2021;Zhang et al, 2014). In addition, previous studies found that PD patients had a significantly higher Regional Homogeneity (ReHo) value in the precentral regions compared with HC group, which might be related to cognitive and behavioral dysfunction of PD patients (Shen & Xu, 2022). Bankssts was found to be associated with the lateralization of motor symptoms, and might play a key role in right-onset of PD (Zhang et al, 2021).…”

Perception, Not Response: The Causes of Abnormal Audiovisual Conflict in Parkinson's disease patients

“…This was consistent with previous findings that the degeneration of brain neurons in PD patients led to extensive cortical thickness thinning of the cerebral cortex 6,13 , such as the temporal, frontal, and parietal regions 14,23 . In addition, previous studies found that PD patients had a significantly higher Regional Homogeneity (ReHo) value in the precentral regions compared with HC group, which might be related to cognitive and behavioral dysfunction of PD patients 24 . Bankssts was found to be associated with the lateralization of motor symptoms, and might play a key role in right-onset of PD 25 .…”

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

“…They provide new avenues for studying functional and structural connectivity, mapping brain networks, decoding cognitive processes, and identifying neurological disease biomarkers. Studying neurological disorders: fMRI is often used to study changes in brain function associated with neurological disorders such as AD, PD, schizophrenia, and depression [17,18]. This can provide insights into the underlying mechanisms of these disorders and help with diagnosis and treatment.…”