Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model

Zhang, Xue; Lv, Xiaoshu; Chen, Mengya; Liu, Haixia

doi:10.1155/2020/6543593

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…Bcl-6 inhibits Blimp-1 and transcription factors of Th1, Th2, and Th17 cells (T-bet, GATA3, and RORγt) to maintain Tfh differentiation 208 , 209 ; Blimp-1 downregulates Bcl-6 and PD-1, inhibiting Tfh differentiation. 209 , 210 ICOS is induced by CD28-CD80/CD86 costimulation and plays an important role in Tfh differentiation by binding to its ligand ICOSL. 211 Studies have shown that ICOS-induced PI3K plays an important role in Tfh differentiation.…”

Section: Differentiation Of Cd4 + T-cell Subsetsmentioning

confidence: 99%

CD4+ T-cell subsets in autoimmune hepatitis: A review

Chen,

Han,

Fan

et al. 2023

Hepatology Communications

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Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis of AIH requires the identification of lymphoblast cell interface hepatitis and serum biochemical abnormalities, as well as the exclusion of related diseases. According to different specific autoantibodies, AIH can be divided into AIH-1 and AIH-2. The first-line treatment for AIH is a corticosteroid and azathioprine regimen, and patients with liver failure require liver transplantation. However, the long-term use of corticosteroids has obvious side effects, and patients are prone to relapse after drug withdrawal. Autoimmune diseases are characterized by an imbalance in immune tolerance of self-antigens, activation of autoreactive T cells, overactivity of B cells, and increased production of autoantibodies. CD4+ T cells are key players in adaptive immunity and can secrete cytokines, activate B cells to produce antibodies, and influence the cytotoxicity of CD8+ T cells. According to their characteristics, CD4+ T cells can be divided into different subsets. In this review, we discuss the changes in T helper (Th)1, Th2, Th17, Th9, Th22, regulatory T cell, T follicular helper, and T peripheral helper cells and their related factors in AIH and discuss the therapeutic potential of targeting CD4+ T-cell subsets in AIH.

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Section: Differentiation Of Cd4 + T-cell Subsetsmentioning

confidence: 99%

CD4+ T-cell subsets in autoimmune hepatitis: A review

Chen,

Han,

Fan

et al. 2023

Hepatology Communications

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“… 1 These tentative factors have been found relating to lymphocytes development and autoimmune diseases. 3 , 4 However, how chromosome remodeling is involved in autoimmune diseases remains largely unknown. Chromodomain helicaseDNA binding protein 4 (CHD4), a newly identified transcription factor, contributes to transcriptional repression, chromatin organization, genomic stability, and cell development.…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, early B cell factor 1 (EBF1), B lymphocyte‐induced maturation protein 1 (Blimp‐1), B‐cell lymphoma 6 protein (Bcl‐6), and histone deacetylases (HDACs) regulate B‐cell development, differentiation, and somatic hypermutation/class switch recombination (CSR) 1 . These tentative factors have been found relating to lymphocytes development and autoimmune diseases 3,4 . However, how chromosome remodeling is involved in autoimmune diseases remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease

Jia

Zou

Yin

et al. 2022

Immunity Inflam & Disease

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Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin assembly. Meanwhile, it is highly related to cell cycle progression and the proceeding of malignancy. Most of the previous studies were focused on the function of CHD4 with tumor cells, cancer stem cells, and cancer cells multidrug resistance. Recently, some researchers have explored the CHD4 functions on the development and differentiation of adaptive immune cells, such as T and B lymphocytes. In this review, we will discuss details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHD4 in the pathogenesis of the autoimmune disease.

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Effects of high-fat diet on thyroid autoimmunity in the female rat

et al. 2022

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Background While contributions of dyslipidemia to autoimmune diseases have been described, its impact on thyroid autoimmunity (TA) is less clear. Programmed cell death 1(PD-1)/PD-ligand 1 (PD-L1) immune checkpoint is crucial in preventing autoimmune attack while its blockade exacerbates TA. We thus unveiled the effect of high-fat diet (HFD) on TA, focusing on the contribution of PD-1/PD-L1. Methods Female Sprague Dawley (SD) rats were randomly fed with a regular diet or HFD (60% calories from fat) for 24 weeks. Then, thyroid ultrasonography was performed and samples were collected for lipid and thyroid-related parameter measure. Results HFD rats exhibited hyperlipemia and abnormal biosynthesis of the unsaturated fatty acid in serum detected by lipidomics. These rats displayed a relatively lower echogenicity and increased inflammatory infiltration in thyroid accompanied by rising serum thyroid autoantibody levels and hypothyroidism, mimicking human Hashimoto’s thyroiditis. These alterations were concurrent with decreased mRNA and immunostaining of intrathyroidal PD-1 and also serum PD-1 levels but not the PD-L1 expression, suggesting a role of a PD-1 pathway. Meanwhile, the infiltration of B and T cell, a key cellular event inhibited by the PD-1 signals, was enhanced in the thyroid of HFD rats, along with thyroid fibrosis and apoptosis. Conclusions Our data suggest that HFD triggers TA through a mechanism possibly involving downregulation of PD-1-related immunosuppression, providing a novel insight into the link between dyslipidemia and autoimmune toxicities.

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Analysis of Blimp-1 and PD-1/PD-L1 Immune Checkpoint in an Autoimmune Thyroiditis Animal Model

Cited by 3 publications

References 39 publications

CD4+ T-cell subsets in autoimmune hepatitis: A review

CD4+ T-cell subsets in autoimmune hepatitis: A review

CHD4 orchestrates the symphony of T and B lymphocytes development and a good mediator in preventing from autoimmune disease

Effects of high-fat diet on thyroid autoimmunity in the female rat

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