2019
DOI: 10.1159/000498919
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Analysis of Biological Properties of Human Adult Mesenchymal Stem Cells and Their Effect on Mouse Hind Limb Ischemia

Abstract: Background: Due to their self-renewal, proliferation, differentiation, and angiogenesis-inducing capacity, human adipose mesenchymal stem cells (AMSC) have potential clinical applications in the treatment of limb ischemia. AMSC from healthy donors have been shown to induce neovascularization in animal models. However, when cells were obtained from donors suffering from any pathology, their autologous application showed limited effectiveness. We studied whether liposuction niche and obesity could determine the … Show more

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Cited by 6 publications
(6 citation statements)
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“…In the past years, there has been an increased interest in developing novel therapeutic products aiming to improve tissue perfusion and/or restoration of tissue function in these patients [25]. The mouse model of HLI is considered the most clinically relevant pre-clinical model of PAD, and especially CLI [26], and has been largely used to assess pre-clinical e cacy of cell therapy products such as mesenchymal stromal cells (MSCs) [27][28][29][30][31]. In most cases, a complete morphologic assessment of tissue using a range of histological techniques is performed for treatment group comparisons.…”
Section: Discussionmentioning
confidence: 99%
“…In the past years, there has been an increased interest in developing novel therapeutic products aiming to improve tissue perfusion and/or restoration of tissue function in these patients [25]. The mouse model of HLI is considered the most clinically relevant pre-clinical model of PAD, and especially CLI [26], and has been largely used to assess pre-clinical e cacy of cell therapy products such as mesenchymal stromal cells (MSCs) [27][28][29][30][31]. In most cases, a complete morphologic assessment of tissue using a range of histological techniques is performed for treatment group comparisons.…”
Section: Discussionmentioning
confidence: 99%
“…In the past years, there has been an increased interest in developing novel therapeutic products aiming to improve tissue perfusion and/or restoration of tissue function in these patients [25]. The mouse model of HLI is considered the most clinically relevant pre-clinical model of PAD, and especially CLI [26], and has been largely used to assess pre-clinical e cacy of cell therapy products such as mesenchymal stromal cells (MSCs) [27][28][29][30][31]. In most cases, a complete morphologic assessment of tissue using a range of histological techniques is performed for treatment group comparisons.…”
Section: Discussionmentioning
confidence: 99%
“…PAD is increasingly recognized as an important cause of cardiovascular morbidity and mortality that affects >230 million people worldwide [ 143 ]. It is estimated that 25% of patients diagnosed with PLI will die within 1 year, and an additional 30% will receive limb amputation [ 144 ]. The symptoms usually experienced by patients include pain at rest, non-healing ulcers, and tissue necrosis with gangrene [ 145 ].…”
Section: Peripheral/critical Limb Ischemia (Pli/cli)mentioning
confidence: 99%
“…The symptoms usually experienced by patients include pain at rest, non-healing ulcers, and tissue necrosis with gangrene [ 145 ]. Thus far, there is no pharmacotherapeutic agent available for the treatment or prevention of PAD [ 144 ]. Treatment options other than limb amputation are restricted to surgical revascularization, which is not recommended in patients with severe co-morbidity, sepsis, limb gangrene, or non-ambulatory individuals [ 146 ].…”
Section: Peripheral/critical Limb Ischemia (Pli/cli)mentioning
confidence: 99%