Analysis of bioheat transfer equation for hyperthermia cancer treatment

Attar, Mohammad Mahdi; Haghpanahi, Mohammad; Amanpour, Saeid; Mohaqeq, Mohammad

doi:10.1007/s12206-013-1141-4

Cited by 34 publications

(18 citation statements)

References 24 publications

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“…heating or cooling), real-time temperature monitoring can be implemented via a metal-free fiber optic sensor that is not affected by the strong applied AMF, or by temperature mapping performed using magnetic resonance temperature imaging [120] or a remote infrared camera. Additionally, the conventional CEM43°C T 90 value and FEM simulations of the bio-heat transfer equation [121] can also be obtained for correlation and comparison. Moreover, to evaluate the extent of thermal damage to the tissues, histology can be performed and compared with both the elasticity and temperature changes.…”

Section: Discussionmentioning

confidence: 99%

Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics

Huang¹,

Pande

Ahmad

et al. 2016

IEEE J. Select. Topics Quantum Electron.

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Magnetic nanoparticles (MNPs) have been used in many diagnostic and therapeutic biomedical applications over the past few decades to enhance imaging contrast, steer drugs to targets, and treat tumors via hyperthermia. Optical coherence tomography (OCT) is an optical biomedical imaging modality that relies on the detection of backscattered light to generate high-resolution cross-sectional images of biological tissue. MNPs have been utilized as imaging contrast and perturbative mechanical agents in OCT in techniques called magnetomotive OCT (MM-OCT) and magnetomotive elastography (MM-OCE), respectively. MNPs have also been independently used for magnetic hyperthermia treatments, enabling therapeutic functions such as killing tumor cells. It is well known that the localized tissue heating during hyperthermia treatments result in a change in the biomechanical properties of the tissue. Therefore, we propose a novel dosimetric technique for hyperthermia treatment based on the viscoelasticity change detected by MM-OCE, further enabling the theranostic function of MNPs. In this paper, we first review the basic principles and applications of MM-OCT, MM-OCE, and magnetic hyperthermia, and present new preliminary results supporting the concept of MM-OCE-based hyperthermia dosimetry.

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Section: Discussionmentioning

confidence: 99%

Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics

Huang¹,

Pande

Ahmad

et al. 2016

IEEE J. Select. Topics Quantum Electron.

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“…Magnetic hyperthermia is a new type of cancer treatment [1][2][3][4], allowing to achieve selective heating of a tumor without damaging of the surrounding healthy tissues. The main idea of this method is in embedding of magnetic nanoparticles in a tumor region and heating them with the help of alternating magnetic field.…”

Section: Introductionmentioning

confidence: 99%

“…3 k B Tis the dimensionless parameter of the dipolar interaction energy between two particles to the thermal energy k B T, m=Mpv, v = 4 is the volume of particle, is the radius particle, of free space, k B = 1.38 • 10 −23 J 0 K…”

mentioning

confidence: 99%

Heat Exchange Within the Surrounding Biological Tissue During Magnetic Hyperthermia

Abu-Bakr¹,

Iskakova²,

Zubarev³

2020

MMEP

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The paper deals with mathematical modeling and theoretical study of the heat distribution within the surrounding biological tissue during the effect of the magnetic hyperthermia. The mathematical model is formulated and solved numerically by using the finite difference method. The intensity of heat production is used in the present model. The obtained results allow predicting the temperature change in tumor as well as in the surrounding tissue depending on intensity of the tumor heating.

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“…Microwave ablation (MWA) is one significant technique in liver tumor treatment. Comparing with the different energy sources, for example, laser, radiofrequency current, and ultrasound, the microwave is a good candidate for a larger ablating zone [5][6][7][8][9][10]. Because MWA is not receptive to tissue coagulated which happens in radiofrequency ablation (RFA) [8,10], the temperature can reach higher and deeper than RFA [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Thermal and Electrical Properties on Porous Liver During Microwave Ablation Using Microwave Coaxial Slot Antenna

Pongpakpien¹,

Preechaphonkul²,

Rattanadecho³

2020

IJHT

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The goal of the microwave ablation is the use of suitable microwave levels which will destroy the target tumor tissues completely without affecting the surrounding healthy tissues. To challenges these phenomena, this work proposes the investigation of porous liver heat model and blood flow including phenomena on thermal and electrical properties effect for enhancing the microwave ablation. The finite element technique is used for solving the transient heat transfer equation and transient momentum equation counterpart with the electromagnetic equation. The verification of the proposed porous model has been conducted by comparing it with the conventional bioheat model and experimental result from previous work. The effect of thermal and electrical properties on thermal transport and blood flow was analyzed. The result has shown that porous liver model agrees with the experimental result than the conventional bioheat model. The characteristic of changed thermal and electrical conductivity of target tissue in porous liver promotes heating rate and lower maximum temperature when compared with normal porous liver tissue conditions. In summary, this study gives the necessary aspects for a principle knowledge of heat transfer in the porous liver and can use as a guideline to enhance the microwave ablation efficacy in future study.

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Analysis of bioheat transfer equation for hyperthermia cancer treatment

Cited by 34 publications

References 24 publications

Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics

Magnetomotive Optical Coherence Elastography for Magnetic Hyperthermia Dosimetry Based on Dynamic Tissue Biomechanics

Heat Exchange Within the Surrounding Biological Tissue During Magnetic Hyperthermia

Effects of Thermal and Electrical Properties on Porous Liver During Microwave Ablation Using Microwave Coaxial Slot Antenna

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