Analysis of Association Between the Serotonin Transporter and Antidepressant Response in a Large Clinical Sample

Kraft, Jeffrey B.; Peters, Eric; Slager, Susan L.; Jenkins, G. Douglas; Reinalda, Megan S.; McGrath, Patrick J.; Hamilton, Steven P.

doi:10.1016/j.biopsych.2006.07.017

Cited by 145 publications

(107 citation statements)

References 46 publications

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“…One study suggested that the G SNP was linked to a reduced response to citalopram [76]; however, in a study using a larger sample (n = 1914), no association was found between this polymorphism and treatment response, although it was not a study of depression post-TBI [77]. The use of the rs25531 SNP augments the existing knowledge of the 5HTTLPR in comparison with previous reports that have not examined it.…”

Section: Discussionmentioning

confidence: 94%

Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury

Lanctôt¹,

Rapoport

Chan³

et al. 2010

Brain Injury

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Objectives-To determine which serotonergic system-related single nucleotide polymorphisms (SNPs) predicted variation in treatment response to citalopram in depression following a traumatic brain injury (TBI).Methods-Ninety (50 M/40 F, aged 39.9, SD = 18.0 years) post-TBI patients with a major depressive episode (MDE) were recruited into a 6-week open-label study of citalopram (20 mg/ day). Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value <0.025). Results-MTHFR CIHR Author Manuscript CIHR Author Manuscript CIHR Author ManuscriptConclusion-Results suggest that polymorphisms in genes related to the serotonergic system may help predict short-term response to citalopram and tolerability to the medication in patients with MDE following a TBI. KeywordsTraumatic brain injury; serotonin receptors; serotonin transporter; brain derived neurotrophic factor (BDNF); methylenetetrahydrofolate reductase (MTHFR); tryptophan hydroxylase (TPH)

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Section: Discussionmentioning

confidence: 94%

Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury

Lanctôt¹,

Rapoport

Chan³

et al. 2010

Brain Injury

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“…112,113 However, findings in Asian and American samples have been inconsistent, including findings of effect in the opposite direction in Korean samples 114,115 and of no association with antidepressant response in a large multicentre USA study. 116 These differential findings suggest that there is no direct association of antidepressant repose and the 5-HTTLPR. Rather, the apparent association may be a marker of other factors, such as polymorphisms in population-specific linkage disequilibria with the 5-HTTLPR.…”

Section: Serotonin Transporter Gene-environment Interaction R Uher Anmentioning

confidence: 99%

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

2007

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“…Many studies have suggested that individuals with 5-HTTLPR S-allele should be more susceptible to depressive symptoms and suicide (Caspi et al 2003;Cervilla et al 2006) and have worse response to antidepressants (Murphy et al 2004;Yu et al 2002). However, the results remained controversial among various populations and areas (Kraft et al 2007;Minov et al 2001;Yoshida et al 2002;Serretti et al 2007). For the STin2 polymorphism, even if some possible positive associations were found with affective disorders (Battersby et al 1996), and response to SSRIs (Kim et al 2000), many studies still have shown contradictory conclusions Yen et al 2003), and therefore further research needs to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response

Min

Ma³

et al. 2009

Psychopharmacology

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Our study revealed a positive association of the NET-T182C polymorphism with susceptibility to and severity of depression, and a positive association between the 5-HTT polymorphisms and the antidepressant response to SSRI. Combinations of these polymorphisms provided some potential gene-gene interaction effects. These findings might be of some clinical values in optimization of depression treatment.

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Analysis of Association Between the Serotonin Transporter and Antidepressant Response in a Large Clinical Sample

Cited by 145 publications

References 46 publications

Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury

Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response

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