Analysis of arterial wall remodeling in hypertension based on lamellar modeling

Taghizadeh, Hadi; Tafazzoli-Shadpour, Mohammad; Shadmehr, Mohammad Behgam

doi:10.1016/j.jash.2015.07.014

Cited by 14 publications

(11 citation statements)

References 48 publications

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“…Stress profiles shown on Figures 3 and 4 indicate the vital role of the fiber orientation on the distribution of circumferential stress in the arterial wall. The profile of the circumferential stress in the arterial wall plays an important role on the regulation of ECM [2]. Stresses higher than physiologic range, stimulate the SMCs and lead to formation of new fibers while, stresses below the normal range, cause fiber degradation in order to keep the mechanical stiffness of the arterial wall in the optimal level.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that the current study investigates the circumferential stress profile resulting from blood pressure and other mechanical couplings between the blood flow and the arterial tissue, e.g. shear stress and harmonic pressure wave, is not considered (additional detail on the FE simulation is published in our previous paper [2]). It should be noted that circumferential stress is the main component of mechanical stimulus that governs the wall remodeling and stimulate smooth muscle cells to synthesize or degrade extracellular matrix (ECM).…”

Section: Finite Element Modelingmentioning

confidence: 99%

“…One of the most important mechanical stimuli in this system is the blood pressure. Blood pressure induces tension in the arterial wall tissue which is sensed by the smooth muscle cells and the appropriate action such as deposition or degradation of the extracellular matrix is taken [1,2]. Also shear stress modulates the transport of lipoproteins and macromolecules from blood flow into the arterial wall and therefore directly affects the formation and progression of atherosclerotic plaques [3].…”

Section: Introductionmentioning

confidence: 99%

“…This mechanical behavior is dictated by the microstructural architecture of the arterial tissue. Hence, exploring these microstructural features and resulting mechanical behavior contributes to deeper understanding of the cardiovascular patho-physiology [2,6].…”

Section: Introductionmentioning

confidence: 99%

“…is composed of a single layer of endothelial cells while the adventitia is constructed by loose connective tissue and serves to attach arterial wall to the surrounding tissues and hence, mechanical behavior of the mid-layer mostly determines the mechanical behavior of the arterial wall [2,7]. On the other hand, microstructure of the media is built of thin and concentric lamellar units.…”

Section: Introductionmentioning

confidence: 99%

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Contribution of Collagen Fibers to the Transmural Stress Distribution in Arterial Wall

Taghizadeh

2018

Zahedan J Res Med Sci

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Background: Cardiovascular system is directly affected by mechanical loads such as blood pressure. Blood pressure induces tension in the arterial wall tissue which is sensed by the smooth muscle cells and the appropriate action such as deposition or degradation of the extracellular matrix is taken. Coupled with the blood pressure, elasticity of the arterial wall govern the load that is sensed by smooth muscle cells. Also the mechanical behavior of the arterial wall is mostly dependent on its fibrous content and hence the orientation of these fibers is a key factor in arterial tissue mechanics. Objectives: The current study aims to illustrate how the fibers can change the transmural stress distribution which will activate smooth muscle cells to balance the fibrous content. Methods: We proposed four models with different fiber orientations across the arterial media and simulated these models in finite element environment. The respective circumferential stress profile from each model is extracted and compared. Results and Conclusions: Obtained stress profiles delineate some similar and some different behaviors, in the case of constant fiber orientation across the wall resulting stress profile is monotonic while with changing the orientation across the wall, the profile becomes different. Our results indicate that considering different fiber orientations across the wall is necessary for prediction of arterial wall remodeling, growth and aging. This role is such that a specific orientation of collagen fibers (model II) results in totally different circumferential stress profile as the respective profile is ascending despite the other three models. These results indicate that single layer models of the arterial wall cannot demonstrate some major characteristics such as circumferential stress profile.

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Section: Discussionmentioning

confidence: 99%

Section: Finite Element Modelingmentioning

confidence: 99%