Analysis of Apoptosis-related Factors and Apoptotic Cells in Lining Epithelium of Odontogenic Keratocysts.

Kimi, Kenji; Kumamoto, Hiroyuki; Ooya, Kiyoshi; Motegi, Katsutoshi

doi:10.3353/omp.5.35

Cited by 22 publications

(40 citation statements)

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“…Moreover, hitstopathologicallY, OOC is very similar to EDC (7,10). A several studies have reported the immunohistochemical analyze in OKC and OOC (3,5,7,8,9), however, the conclusive results have not yet been reported. For that reason, this study focused on identifying differences among OKC, OOC and EDC using immunohistochemical techniques.…”

Section: Discussionmentioning

confidence: 79%

“…Recent studies have suggested that there is a close relationship between bcl-2 protein expression and cell population which are long lived, and/or with high proliferation ability (3,29). Immunoreactivity for bcl-2 protein has been detected in the enamel organs and the dental lamina of tooth germs as well as in most neoplastic cells of ameloblastoma (3,30). OKC showed more aggressive clinical behavior, higher recurrence rate, and a higher proliferative activity than those of OOC and EDC.…”

Section: Discussionmentioning

confidence: 99%

“…The bcl-2 proto-oncogene is a member of a gene family in the suppressors of the programmed cell death (17,(27)(28)(29). Recent studies have suggested that there is a close relationship between bcl-2 protein expression and cell population which are long lived, and/or with high proliferation ability (3,29). Immunoreactivity for bcl-2 protein has been detected in the enamel organs and the dental lamina of tooth germs as well as in most neoplastic cells of ameloblastoma (3,30).…”

Section: Discussionmentioning

confidence: 99%

“…Microscopically, OKC consists of a uniform epithelial lining with a well-developed basal cell layer and a corrugated parakeratinized surface (1,4). Recent studies have discussed the histologic variants (parakeratin vs. orthokeratin) ofOKC (3,(5)(6)(7)(8)(9). Microscopically, the majority of OKC are parakeratinized OKC and orthokeratinized OKCs are only 12.2% (5).…”

Section: Introductionmentioning

confidence: 99%

“…Odontogenic keratocyst (OKC) is a histologically distinct type of developmental odonotogenic cyst that commonly occurs in the tooth-bearing area or in the retromolar region of the jaws (1)(2)(3)(4). OKC is characterized clinically by its aggressive behavior and high tendency for local recurrence (4,5).…”

Section: Introductionmentioning

confidence: 99%

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Odontogenic Keratocyst, Orthokeratinized Odontogenic Cyst and Epidermal Cyst: An Immunohistochemical Study Including Markers of Proliferation, Cytokeratin and Apoptosis Related Factors

Koizumi

2004

Int J Oral-Med Sci

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Objective: There are microscopic similarities among odontogenic keratocyst (OKC), orthokeratinized odontogenic keratocyst (DOC) and epidermal cyst (EDC). This study was to compare with cell proliferation, cell differentiation and apoptosis related factors in OKC, DOC and EDC in order to clarify the characters and category of three hitstopathologically similar cysts.Material and Methods: Fourteen cases of OKC, nine cases of DOC and eighteen cases ofEDC were examined immunohistochemically using antibodies against cytokeratins (CK7,10, 10/13,17,18,19,20) and apoptosis related factors (bcl-2 and Bax).Results: Ki-67 labeling index in OKC was statistically higher than that in DOC and EDC (p<0.05). And that in DOC was higher in EDC (p<0.05). In OKC, CKs and bcl-2 expression patterns were different from DOC and EDC, while both DOC and EDC showed similar reactivity with CKs and bcl-2.Conclusions: The present results suggested that OKC had high cellular proliferation and was relatively low differentiation as compare with DOC and EDC. In addition, there was participation of apoptosis suppressor in OKC. The character of DOC occupied an intermediate position between OKC and EDC. Therefore, it was possible to consider DOC as a distinct entity from OKC. EDC had the lowest cellular activity in the three cysts and it was comparatively maturated lesion.

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