Analysis of Antitumor Activity of the Liposomal Photosensitizer Lipophthalocyan

Ланцова, А. В.; Борисова, Л. М.; Меерович, Г. А.; Bunyatyan, N. D.; Olefir, Yu. V.; Прокофьев, А. Б.; Евтеев, В. А.; Sapovskii, M. M.; Киселева, М. П.; Санарова, Е. В.; Орлова, О. Л.; Дмитриева, М. В.; Полозкова, А. П.; Оборотова, Н. А.; Ogay, Marina Alekseevna; Khadzhieva, Z. J.; Nikolaeva, L. L.

doi:10.1007/s10517-020-04709-9

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Staff at the N. N. Blokhin National Medical Research Center of Oncology developed Lipophthalocyan, an injectable liposomal formulations of an antineoplastic hydrophobic photosensitizer, the active component of which is tetra-3-phenylthiophthalocyanine aluminum hydroxide. The advantages of this medicine include its high degree of selectivity in targeting the nidus of a tumor, its low toxicity for the system and its high level of effectiveness, as confirmed by in vivo and in vitro testing [1]. The proposed drug has considerable potential for use in photodynamic therapy for surface and internal neoplasms, particularly cancers of the skin and lower lip and tumors of the tunica mucosa of the mouth and tongue.…”

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confidence: 93%

Validation of the Qualitative Determination of HPLC Metods for Sucrose and Peg-2000-Dspe in a Liposomal Form of the Photosensitizer Lipophthalocyan

Ланцова¹,

Санарова²,

Дмитриева³

et al. 2020

Int J App Pharm

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Objective: This study was undertaken with the aim of the validate the simple isocratic metods high-performance liquid chromatographic (HPLC) for the estimation of PEG-2000-DSPE and sucrose in liposomal medicinal formulations of the phthalocyanine photosensitizer Lipophthalocyan. Methods: HPLC quantification was carried out by using of YMC-Pack Polyamine II column. The mobile phase (for sucrose: acetonitrile: water: ethyl acetate in the ratio of 450: 200: 20; for PEG-2000-DSPE: water in the ratio 10: 90) was pumped at a flow rate of 1 ml/min. Following the guidelines of the International Conference on Harmonization (ICH), the methods was validated for various analytical parameters like specificity, linearity, detection limit, quantitative limit, correctness, and accuracy. Results: The obtained results of the analysis were validated statistically. The correlation coefficient for the linearity was 0.999292, for sucrose, and 0.997650 for PEG-2000-DSPE. The methods can be assessed as correct, as the results obtained are close to the true value and the confidence interval for both methods include 100%. The coefficients of variation in both methods in determining the accuracy were less than 3%. Conclusion: The proposed HPLC methods were validated according to the ICH guidelines and results and statistical parameters demonstrated that the developed methods are sensitive, precise, reliable and simple for the estimation of PEG-2000-DSPE and sucrose in Lipophthalocyan.

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mentioning

confidence: 93%

Validation of the Qualitative Determination of HPLC Metods for Sucrose and Peg-2000-Dspe in a Liposomal Form of the Photosensitizer Lipophthalocyan

Ланцова¹,

Санарова²,

Дмитриева³

et al. 2020

Int J App Pharm

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Nanomaterials for Pharmaceutical Applications

SINGH

Tiwari

Tyagi

2021

Emerging Trends in Nanotechnology

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Liposomes as a Targeted Delivery System of Drugs (Review)

Горбик

Shprakh

Козлова

et al. 2021

Rossijskij bioterapevtičeskij žurnal

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Liposomal targeted drug delivery makes it possible to achieve effective concentration in the target cell under various pathological conditions. The main advantage of liposomal particles is their biodegradability and immunological neutrality, which improves the safety profile of drugs. The review provides information on the composition of liposomes: the main component of the liposomal membrane is phospholipids, which provide its strength and protect from mechanical impacts. Liposomal particles are distinguished by the size and number of bilayer membranes, also secreted liposomes with a non‑lamellar organization. The composition and size of liposomes are selected depending on the purpose, including excipients in the membrane that affect the properties and functions of liposomes, including the rate of release of the components, the affinity of liposomes for the target tissue, etc. The review considers the main methods for obtaining liposomes and the features of their use, advantages and disadvantages. The creation of liposomes that are sensitive to various external or internal physicochemical factors makes it possible to realize drugs effects, localize the site of its action and reduce the number and severity of side effects. Currently, liposome‑based drugs are successfully used in various fields of medicine – dermatology, cardiology, oncology, neurology, etc. The most active condact preclinical and clinical studies of liposomal drugs for the treatment of malignant neoplasms. Particular attention is paid to the work of Russian researchers in the field of targeted drug delivery. It is shown that today liposomes are an open for study and improvement system for targeted drug delivery.

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Analysis of Antitumor Activity of the Liposomal Photosensitizer Lipophthalocyan

Cited by 3 publications

References 10 publications

Validation of the Qualitative Determination of HPLC Metods for Sucrose and Peg-2000-Dspe in a Liposomal Form of the Photosensitizer Lipophthalocyan

Validation of the Qualitative Determination of HPLC Metods for Sucrose and Peg-2000-Dspe in a Liposomal Form of the Photosensitizer Lipophthalocyan

Nanomaterials for Pharmaceutical Applications

Liposomes as a Targeted Delivery System of Drugs (Review)

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