Analysis of anticoagulation therapy related complications in patients with prosthetic valves: Our experience

Abstract

Purpose: The aim of this study is to analyze anticoagulation-related complications in patients following mechanical valve replacement and factors influencing the outcome. Materials and Methods: A total of 250 patients were analyzed during OPD follow-up for anticoagulation-related complications and various factors influencing outcome. Patients received prosthetic valve at mitral and/or aortic or both. Results: Out of 250 patients, 48% were male and 52% were female. The mean age was 41.9 ± 14.4. A total of 139 had mitral valve replacement (MVR), 70 had aortic valve replacement (AVR), 40 had double valve replacement (DVR), and 1 patient had triple valve replacement. Valves implanted were mechanical bileaflet valve. The mean international normalization ratio (INR) in the study was 2.4 ± 0.56. A total of 49 events occurred during follow-up, of which 4.5% per patient years were anticoagulation-related hemorrhagic events and 4.8% per patient years were thromboembolic events. Among thromboembolic events, valve thrombosis occurred in 10 patients and cerebrovascular accidents occurred in 11 patients. Mean INR for thromboembolic events was 1.46 ± 0.25 and anticoagulation-related hemorrhagic events was 4.4 ± 1.03. Mortality rate was 1.6% in AVR, 4% in MVR, and 0.4% in DVR groups; about 34% of patients needed dose modification of Acenocoumarol and reason for derangement of INR was associated with infectious process and poor compliance; 85% of cases showed good compliance for daily anticoagulation therapy. Conclusion: Anticoagulation for mechanical valve replacement can be managed with INR range of 2.0 to 2.5 in MVR and 1.5 to 2.0 in AVR with acceptable hemorrhagic and thromboembolic events. We must educate and counsel the patients during follow-up for better compliance to optimal anticoagulation.

Stability of Anticoagulation Following Acenocoumarin in Stroke Patients: Role of Pharmacogenomics and Acquired Factors

“…Singh et al . [ 31 ] reported anticoagulation-related hemorrhagic events in 4.5% of patients per year and thromboembolic events in 4.8% of patients per year with prosthetic valve. In the present study also, hemorrhagic complication was associated with high INR and thrombotic complication was associated with low INR.…”

Nanotechnology in interventional cardiology: A state-of-the-art review

“…Valve replacement using a bioprosthetic valve usually results in a rapid ectopic calcification and its durability is shortened due to its tendency to mechanical failure. On the other hand, the replacement of mechanical valves requires long-term anticoagulant treatment and may be subject to life-threatening hemodynamic failure [53] . Therefore, there is an urgent need to develop new therapies that can help reduce or overcome current problems.…”

Bioprosthetic aortic valve replacement: The right valve at the right patient by the right surgeon: The key to success

“…The implantation of a biological prosthesis has become nowadays the most common approach to any aortic valve disease requiring valve replacement 1 . Also young and active patients more and more frequently ask for a biological aortic valve substitute, primarily with the aim of avoiding all the drawbacks related to the anticoagulant therapy 2 . The two most desirable characteristics of a good bioprosthesis consist of its extended durability and its adequate hemodynamics.…”

“…1 Also young and active patients more and more frequently ask for a biological aortic valve substitute, primarily with the aim of avoiding all the drawbacks related to the anticoagulant therapy. 2 The two most desirable characteristics of a good bioprosthesis consist of its extended durability and its adequate hemodynamics. As we shall see, the two features are interdependent.…”