Analysis of antibacterial efficacy of plasma-treated sodium chloride solutions

Hänsch, Mareike; Mann, Miriam; Weltmann, Klaus‐Dieter; Woedtke, Thomas von

doi:10.1088/0022-3727/48/45/454001

Cited by 33 publications

(31 citation statements)

References 51 publications

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“…For comprehensive summaries of the broad variety of discharges in combination with liquids, please refer to [1,14,15]. Regarding the treatment of water, changes of its properties have been examined by many researchers [6][7][8][9][16][17][18][19]. In all cases of discharges operated in contact with or in close vicinity to water, acidification (except for tap water) and nitration was observed.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, it was described that chemical contaminations, e.g., with pharmaceuticals, in the water were decomposed over the course of the plasma treatment [20][21][22]. Further experiments revealed that the plasma-treated water became antimicrobial [5,7,18]. In these experiments, bacteria such as Staphylococcus aureus and Escherichia coli were significantly inactivated.…”

Section: Introductionmentioning

confidence: 99%

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Plasma-Activation of Larger Liquid Volumes by an Inductively-Limited Discharge for Antimicrobial Purposes

et al. 2019

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A new configuration of a discharge chamber and power source for the treatment of up to 1 L of liquid is presented. A leakage transformer, energizing two metal electrodes positioned above the liquid, limits the discharge current inductively by utilizing the weak magnetic coupling between the primary and secondary coils. No additional means to avoid arcing (electric short-circuiting), e.g., dielectric barriers or resistors, are needed. By using this technique, exceeding the breakdown voltage leads to the formation of transient spark discharges, producing non-thermal plasma (NTP). These discharges effected significant changes in the properties of the treated liquids (distilled water, physiological saline solution, and tap water). Considerable concentrations of nitrite and nitrate were detected after the plasma treatment. Furthermore, all tested liquids gained strong antibacterial efficacy which was shown by inactivating suspended Escherichia coli and Staphylococcus aureus. Plasma-treated tap water had the strongest effect, which is shown for the first time. Additionally, the pH-value of tap water did not decrease during the plasma treatment, and its conductivity increased less than for the other tested liquids.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma-Activation of Larger Liquid Volumes by an Inductively-Limited Discharge for Antimicrobial Purposes

et al. 2019

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“…Furthermore, the method could be efficient in generating peroxinitrite (ONOO − ) in plasma-treated liquids, a species which contributes to the antibacterial properties of plasma activated liquids and is often associated to its longterm efficacy. [36][37][38][39]…”

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confidence: 99%

How to produce an NO_x- instead of O_x-based chemistry with a cold atmospheric plasma jet

Schmidt-Bleker

Bansemer

Reuter

et al. 2016

Plasma Process. Polym.

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A novel method is presented, which allows to generate a nitrogen oxides (NOx)‐dominated chemistry with a cold atmospheric plasma (CAP) jet which typically produces an oxygen‐based reactive species (Ox) cocktail. The reactive oxygen and nitrogen (RONS) production of the CAP jet kinpen is monitored using Fourier transform infrared (FTIR) absorption spectroscopy. While in previous approaches, the plasma chemistry of CAP jets operated with noble gases has been influenced with molecular feed gas admixtures of O2 and N2, humidified feed gas, and shielding gas, these methods are now combined in order to obtain a previously unattainable range of operating regimes: The plasma chemistry can be tuned continuously from Ox to NOx dominated, while the degree of oxidation of the produced NOx can easily be influenced.

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“…Other studies have indicated that the ratio of aqueous NO 2 - to H 2 O 2 in addition to plasma discharge parameters are critical to establish long-term antibacterial effects of saline solutions. 84 To further extend the shelf life of PAW solutions, it has been demonstrated that the addition of N -acetyl-cysteine (NAC) prior to plasma treatment resulted in solutions with a shelf life of 2 years; however, the mechanism is unclear. 185 These results indicate the potential for these plasma-activated solutions to be prepared in advance for subsequent shipment, storage, and clinical use; however, if shelf-life limitations become apparent in future work, the commercial focus may shift to on-site generation for direct use upon preparation.…”

Section: App Applicationsmentioning

confidence: 99%

“…84 This approach has been proposed in light of the complex plasma species involved that suggest multiple modes of disinfectant action, where plasma treatment in general has been implicated for broad spectrum bacterial kill. 186 Antibacterial resistance is currently an overwhelming issue in the healthcare arena; thus, the development of plasma-activated aqueous solutions with the capability to address this problem and effectively reduce bacterial loads will be hugely beneficial.…”

Section: App Applicationsmentioning

confidence: 99%

Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications

et al. 2016

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Plasma pharmacy is a subset of the broader field of plasma medicine. Although not strictly defined, the term aqueous plasma pharmacy (APP) is used to refer to the generation and distribution of reactive plasma-generated species in an aqueous solution followed by subsequent administration for therapeutic benefits. APP attempts to harness the therapeutic effects of plasma-generated oxidant species within aqueous solution in various applications, such as disinfectant solutions, cell proliferation related to wound healing, and cancer treatment. The subsequent use of plasma-generated solutions in the APP approach facilitates the delivery of reactive plasma species to internal locations within the body. Although significant efforts in the field of plasma medicine have concentrated on employing direct plasma plume exposure to cells or tissues, here we focus specifically on plasma discharge in aqueous solution to render the solution biologically active for subsequent application. Methods of plasma discharge in solution are reviewed, along with aqueous plasma chemistry and the applications for APP. The future of the field also is discussed regarding necessary research efforts that will enable commercialization for clinical deployment.

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Analysis of antibacterial efficacy of plasma-treated sodium chloride solutions

Cited by 33 publications

References 51 publications

Plasma-Activation of Larger Liquid Volumes by an Inductively-Limited Discharge for Antimicrobial Purposes

Plasma-Activation of Larger Liquid Volumes by an Inductively-Limited Discharge for Antimicrobial Purposes

How to produce an NO_x- instead of O_x-based chemistry with a cold atmospheric plasma jet

Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications

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Analysis of antibacterial efficacy of plasma-treated sodium chloride solutions

Cited by 33 publications

References 51 publications

Plasma-Activation of Larger Liquid Volumes by an Inductively-Limited Discharge for Antimicrobial Purposes

Plasma-Activation of Larger Liquid Volumes by an Inductively-Limited Discharge for Antimicrobial Purposes

How to produce an NOx- instead of Ox-based chemistry with a cold atmospheric plasma jet

Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications

Contact Info

Product

Resources

About

How to produce an NO_x- instead of O_x-based chemistry with a cold atmospheric plasma jet