Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV

Li, Rui; Qiao, Songlin; Zhang, Gaiping

doi:10.1016/j.jinf.2020.02.013

Cited by 113 publications

(132 citation statements)

References 10 publications

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“…Some studies have suggested that SARS-CoV-2 predominantly enters alveolar epithelial cells through the human ACE2 receptor. 19,20 Therefore, the lung is considered the main target organ of SARS-CoV-2 infection. However, previous studies have found that bile duct epithelial cells may also express ACE2 receptor at a concentration 20 times higher than in hepatocytes and these findings suggest that SARS-CoV-2 infection might also cause bile duct epithelial cell damage.…”

Section: Putative Mechanisms Of Covid-19-related Liver Dysfunctionmentioning

confidence: 99%

COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

Feng¹,

Zheng²,

Yan³

et al. 2020

Journal of Clinical and Translational Hepatology

366

380

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The outbreak of coronavirus disease 2019 , caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has attracted increasing worldwide attention. Cases of liver damage or dysfunction (mainly characterized by moderately elevated serum aspartate aminotransferase levels) have been reported among patients with COVID-19. However, it is currently uncertain whether the COVID-19related liver damage/dysfunction is due mainly to the viral infection per se or other coexisting conditions, such as the use of potentially hepatotoxic drugs and the coexistence of systemic inflammatory response, respiratory distress syndromeinduced hypoxia, and multiple organ dysfunction. Based on the current evidence from case reports and case series, this

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Section: Putative Mechanisms Of Covid-19-related Liver Dysfunctionmentioning

confidence: 99%

COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

Feng¹,

Zheng²,

Yan³

et al. 2020

Journal of Clinical and Translational Hepatology

366

380

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“…Biophysical and structural evidence that new SARS-CoV-2 may bind ACE2 receptor with higher affinity than SARS-CoV has been recently reported [9]. The wide distribution and similarity of this receptor in the animal kingdom may account for cross-species transmission [16], while the pattern of expression of ACE2 in human respiratory epithelia and oral mucosa may explain the fast humanhuman transmission [17]. Despite the crucial need for a clinical strategy to counteract this epidemiological outbreak, no specific drug has been identified yet.…”

Section: Introductionmentioning

confidence: 99%

Master Regulator Analysis of the SARS-CoV-2/Human interactome

Guzzi

Mercatelli

Ceraolo

et al. 2020

Preprint

103

119

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the recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 and causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. In this paper, we set out to shed light on the SARS-CoV-2/host receptor recognition, a crucial factor for successful virus infection. Based on the current knowledge of the interactome between SARS-CoV-2 and host cell proteins, we performed Master Regulator Analysis to detect which parts of the human interactome are most affected by the infection. We detected, amongst others, affected apoptotic and mitochondrial mechanisms, and a downregulation of the ACE2 protein receptor, notions that can be used to develop specific therapies against this new virus.

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“…Protein repertoire of the coronaviruses consists of four main structural and approximately 16 major non-structural proteins [3,7]. Among the four structural proteins, the Spike protein (also known as S-protein) is involved in host tropism by means of recognition and attachment to the angiotensin-converting enzyme 2 (ACE2) receptor exposed in the outer layer of the host cell membrane [8]. A very recent amino acid sequence alignment of ACE2 from different animal species including humans, pets and the major domestic animals highlighted high protein sequence similarity between the tested animal species, suggesting a potential interaction of the viral particles with a wider array of host cells [8].…”

mentioning

confidence: 99%

“…In accordance with the hypothesis of interspecies transmission of the beta coronaviruses [8], we performed sequence homology analysis of the aminoacidic sequence of the Spike protein from SARS CoV-2 against taxonomically related coronaviruses with tropism for other animal species. Although the low homology scored while comparing the whole protein sequence (Table 1), particular interest was dedicated to the canine respiratory coronavirus, the bovine coronavirus revealing and the human enteric coronavirus 36.93%, 38.42% and 37.68% sequence homology to SARS CoV-2 spike protein, respectively.…”

mentioning

confidence: 99%

Molecular basis of COVID-19 relationships in different species: a one health perspective

Tilocca

Soggiu

Musella

et al. 2020

Microbes and Infection

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a b s t r a c tOutside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of "unconventional" biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.

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Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV

Cited by 113 publications

References 10 publications

COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies

Master Regulator Analysis of the SARS-CoV-2/Human interactome

Molecular basis of COVID-19 relationships in different species: a one health perspective

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