Analysis of an automated background correction method for cardiovascular MR phase contrast imaging in children and young adults

Rigsby, Cynthia K.; Hilpipre, Nicholas; McNeal, Gary R; Zhang, Gang; Boylan, Emma E.; Popescu, Andrada; Choi, Grace; Greiser, Andreas; Deng, Jie

doi:10.1007/s00247-013-2830-y

Cited by 15 publications

(10 citation statements)

References 10 publications

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“…Recently, automated background correction was assessed in a heterogeneous population of patients referred for phase contrast MRI, including 15 TOF patients. Background correction improved the quantification of flow in these patients [ 17 ]. However, clinical implications for a homogenous cohort of patients were lacking.…”

Section: Discussionmentioning

confidence: 99%

“…Especially for congenital heart diseases this phantom correction may therefore be time-consuming, because clinical assessment of these patients generally include multiple phase contrast sequences. Therefore, post-processing image correction, based on phase offset elimination across regions of signal from static tissues, has been developed [ 15 – 17 ]. This automated background correction method is promising, yet the clinical consequences are unknown.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary regurgitant volume is superior to fraction using background-corrected phase contrast MRI in determining the severity of regurgitation in repaired tetralogy of Fallot

Gorter

Melle

Freling

et al. 2015

Int J Cardiovasc Imaging

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In the assessment of pulmonary regurgitation (PR) using phase contrast MRI, phase offset errors affect the accuracy of flow. This study evaluated the use of automated background correction for phase offset in the quantification of PR fraction and volume in patients with repaired tetralogy of Fallot (TOF), and to assess its clinical impact. We retrospectively analyzed 203 cardiac MRI studies, performed on 1.5-T scanner. Pulmonary flow (QP) and systemic flow (QS) was assessed both with and without background correction. Non-corrected and corrected QP was correlated with QS. PR was correlated with (1) indexed right ventricular end-diastolic volume (RVEDVi) and (2) with differential right and left ventricular stroke volumes (PRSV). Both PR fraction and volume showed major change after correction (−43 to +36 % and −13 to +13 ml/m2). Corrected QP and QS were stronger correlated with each other than non-corrected QP and QS [r = 0.78 vs. 0.73 (p < 0.001)]. Both PR fraction and volume were stronger correlated with RVEDVi, compared to their non-corrected counterparts (p < 0.001). PR volume was stronger correlated with RVEDVi, compared to PR fraction [r = 0.74 vs. 0.69 (p < 0.001)]. When patients were divided according to PR severity, 12 % of patients reclassified after correction. Background correction for phase offset significantly changed the quantification of PR. Non-corrected assessment of PR may result in the misclassification of patients. Our data suggest that the use of PR volume is favourable in the follow-up of patients with repaired TOF.Electronic supplementary materialThe online version of this article (doi:10.1007/s10554-015-0670-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary regurgitant volume is superior to fraction using background-corrected phase contrast MRI in determining the severity of regurgitation in repaired tetralogy of Fallot

Gorter

Melle

Freling

et al. 2015

Int J Cardiovasc Imaging

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“…Q s is typically assessed from an additional 2D PC measurement through the ascending aorta with minimal time delay to the pulmonary flow measurement. 29 Employing velocity offset corrections for both measurements, normal Q p : Q s ratios of 1.0 ± 0.1, 37 1.05 ± 0.07 71 and 0.98 ± 0.11 72 are reported. Current guidelines 2 recommend PC imaging-based assessment of Q p : Q s to exclude atrial septal defects and/or anomalous pulmonary venous return in the diagnostic work-up of patients with PH.…”

Section: Standard Pc Parameters Of the Main Pulmonary Artery In Phmentioning

confidence: 99%

MR phase-contrast imaging in pulmonary hypertension

Reiter

Fuchsjäger

2016

BJR

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Pulmonary hypertension (PH) is a life-threatening, multifactorial pathophysiological haemodynamic condition, diagnosed when the mean pulmonary arterial pressure equals or exceeds 25 mmHg at rest during right heart catheterization. Cardiac MRI, in general, and MR phase-contrast (PC) imaging, in particular, have emerged as potential techniques for the standardized assessment of cardiovascular function, morphology and haemodynamics in PH. Allowing the quantification and characterization of macroscopic cardiovascular blood flow, MR PC imaging offers non-invasive evaluation of haemodynamic alterations associated with PH. Techniques used to study the PH include both the routine two-dimensional (2D) approach measuring predominant velocities through an acquisition plane and the rapidly evolving four-dimensional (4D) PC imaging, which enables the assessment of the complete time-resolved, three-directional blood-flow velocity field in a volume. Numerous parameters such as pulmonary arterial mean velocity, vessel distensibility, flow acceleration time and volume and tricuspid regurgitation peak velocity, as well as the duration and onset of vortical blood flow in the main pulmonary artery, have been explored to either diagnose PH or find non-invasive correlates to right heart catheter parameters. Furthermore, PC imaging-based analysis of pulmonary arterial pulse-wave velocities, wall shear stress and kinetic energy losses grants novel insights into cardiopulmonary remodelling in PH. This review aimed to outline the current applications of 2D and 4D PC imaging in PH and show why this technique has the potential to contribute significantly to early diagnosis and characterization of PH.

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“…These errors, which manifest as phase shifts on a regional, global, and temporal basis, will compromise the ability to accurately quantify integrated parameters such as stroke volume 231-234 . A number of studies have investigated various correction approaches 57,234-236 ; however, there is no widespread agreement as to a universal correction protocol. The lack of standardised analysis tools for regional flow quantification and analysis of PC data with three-directional velocity encoding and/or 3D volumetric coverage is currently a major hurdle for their more widespread clinical application.…”

Section: Discussionmentioning

confidence: 99%

Advanced flow MRI: emerging techniques and applications

et al. 2016

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Magnetic resonance imaging (MRI) techniques provide non-invasive and non-ionising methods for the highly accurate anatomical depiction of the heart and vessels throughout the cardiac cycle. In addition, the intrinsic sensitivity of MRI to motion offers the unique ability to acquire spatially registered blood flow simultaneously with the morphological data, within a single measurement. In clinical routine, flow MRI is typically accomplished using methods that resolve two spatial dimensions in individual planes and encode the time-resolved velocity in one principal direction, typically oriented perpendicular to the two-dimensional (2D) section. This review describes recently developed advanced MRI flow techniques, which allow for more comprehensive evaluation of blood flow characteristics, such as real-time flow imaging, 2D multiple-venc phase contrast MRI, four-dimensional (4D) flow MRI, quantification of complex haemodynamic properties, and highly accelerated flow imaging. Emerging techniques and novel applications are explored. In addition, applications of these new techniques for the improved evaluation of cardiovascular (aorta, pulmonary arteries, congenital heart disease, atrial fibrillation, coronary arteries) as well as cerebrovascular disease (intra-cranial arteries and veins) are presented.

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Analysis of an automated background correction method for cardiovascular MR phase contrast imaging in children and young adults

Cited by 15 publications

References 10 publications

Pulmonary regurgitant volume is superior to fraction using background-corrected phase contrast MRI in determining the severity of regurgitation in repaired tetralogy of Fallot

Pulmonary regurgitant volume is superior to fraction using background-corrected phase contrast MRI in determining the severity of regurgitation in repaired tetralogy of Fallot

MR phase-contrast imaging in pulmonary hypertension

Advanced flow MRI: emerging techniques and applications

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