Analysis of Alpina officinarum Hance, chemically and biologically

Abstract

Alpinia officinarum Hance is one of the most commonly used herbs belongs to Family Zingiberaceae. The current work deals with the qualitative and quantitative chemical study of this plant rhizomes in addition to the investigation of its anticancer activities. The results of the qualitative analysis showed a variation of phytochemical contents in this plant. While quantitative analysis showed a very promising percentage of active materials and Pharmacopeial constants. Analysis of elements like Cu, Zn & Mg were variable chromium was the lowest (0.680 ppm). The active constituents showed the highest percentage of carbohydrate (20.25 ± 1.11) and the lowest was of lipid (2.79 ± 1.03), other constituents percentage ranged from 5.11 ± 1.31 to 18.26 ± 1.24 for protein and flavonoids respectively. The pharmacopeial constant determinations reported the highest in moisture content (11.02 ± 1.05), Total ash, water-soluble ash, and acid insoluble ash were varied in values (5.64 ± 1.31 to 2.01 ± 1.12).The evaluation of the antitumor activities (in vitro) of the investigated plant rhizomes extract showed that; it exhibited a direct cytotoxic effect on the growth of some cell lines compared to the standard drug vinblastine sulphate. The activities were recorded against two cell lines; A-549 (Lung carcinoma) and CACO (colorectal carcinoma) with IC50 6.72 ± 0.5 and 7.6 ± 0.3 µg/ml respectively, these effects were better than the standard drug vinblastine sulphate (IC50 were 24.6 ± 0.7& 30.3 ± 1.4 µg/ml). Moreover, the effect of the investigated extract was also promising on the other three cell lines (HCT-116 (Colon carcinoma, Hela (Cervical carcinoma) & Pc3 (prostate cancer) the best effect was on Hela with IC50 of 24.5 ± 1.1 µg/ml better than vinblastine sulphate (59.7 ± 2.1 µg/ml).

Effect of Adding Alpinia officinarum Powder on The Properties and Shelf Life of White Soft Cheese Made from Goat's Milk

“…The phenolic content and antioxidant activity in AOP may be responsible for the increased antioxidant activity of supplemented cheese. These results were in agreement with Housman et al, (2014) and Alasmary et al, (2019). Table 6, showed, also, that adding AOP to cheese was accompanied by high amounts of dietary fibers, because AOP has a higher dietary fiber content, 16.6 % (Gazal et al, 2014 andTang et al, 2018).…”

Antibacterial Activity and Components of the Methanol-Phase Extract from Rhizomes of Pharmacophagous Plant Alpinia officinarum Hance

“…One such herb is Alpinia officinarum Hance that is known as the smaller galangal. A. officinarum Hance belongs to the Zingiberaceae family and is widely cultivated in southern China and many Asian countries [3]. The rhizomes of A. officinarum Hance have been used as a traditional medicine to relieve stomachache, to invigorate circulation, treat colds, and to reduce swelling for over 1000 years.…”

“…Previous studies have revealed three major groups of chemical constituents isolated from the rhizomes of the smaller galangal, including flavonoids, glycosides and diarylheptanoids [5]. Recently, pharmacological activities of these phytochemicals have been reported, including anti-inflammatory, antioxidant, and anticancer effects [3,6,7]. Nevertheless, the current literature is limited with respect to the bacteriostatic activity of the herb rhizomes.…”

Evaluation of the chemical constituents and potential biological activities of Cunninghamella blakesleeana

“…The oral median lethal dose (LD 50 ) of the investigated alcohol extract determined at doses up to 4000 mg/kg ( Alasmary et al, 2019 ).…”