Analysis of alkyl methylphosphonic acids in aqueous matrices by ion-pair reversed-phase ion chromatography

Bossle, P.C.; Reutter, Dennis J.; Sarver, Emory W.

doi:10.1016/s0021-9673(01)92644-5

Cited by 51 publications

(13 citation statements)

References 2 publications

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“…CWA screening will be conducted during field activities and by the CRDEC in the CRDEC Laboratory with methods developed at APG by Bossle et al (1988Bossle et al ( , 1989Bossle et al ( , 1990. A field technique based on colorimetry developed by USATHAMA (USATHAMA 1984) will be used in the OSL to analyze for nitroaromatics.…”

Section: Munition Compounds and Chemical Warfare Agentsmentioning

confidence: 99%

“…USATHAMA methodologies, including those developed by the CRDEC at APG (Bossle et al 1988(Bossle et al , 1989, 19901, will be used for chemical analysis of explosives, CWA degradation products, and water chemistry analytes. These analytes are listed in Tables 8.6 through 8.11.…”

Section: Laboratory Analytical Proceduresmentioning

confidence: 99%

“…Explosives will be analyzed by HPLC with USATHAMA Methods UW14 (aqueous) and LW12 (solid) and/or as proposed by Bossle et al (1988Bossle et al ( , 1989Bossle et al ( , 1990 (Tables 8.18 and 8.19). The methods involve solid-phase extraction of 500 mL of an environmental aqueous sample or 1 g of environmental solid sample with acetonitrile.…”

Section: -34mentioning

confidence: 99%

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Remedial investigation sampling and analysis plan for J-Field, Aberdeen Proving Ground, Maryland: Volume 2, Quality Assurance Project Plan

Prasad¹,

Martino²,

Patton³

1995

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Section: Munition Compounds and Chemical Warfare Agentsmentioning

confidence: 99%

Section: Laboratory Analytical Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Remedial investigation sampling and analysis plan for J-Field, Aberdeen Proving Ground, Maryland: Volume 2, Quality Assurance Project Plan

Prasad¹,

Martino²,

Patton³

1995

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“…9 Recently Sadi et al 9 applied ICP-MS detection to phosphorus containing herbicides through the use of state of the art collision/reaction cell technology. Separation of two phosphorus based general purpose herbicides, as well as aminomethylphosphonic acid (AMPA) by reversed phase ionpairing high-performance liquid chromatography (RP-IP-HPLC) 18 achieved detection limits of less than 32 pg mL À1 . 9 In this study reversed phase ion-pairing chromatography was coupled with ICP-MS detection for the analysis of three organophosphorus degradation products of Sarin (GB) and VX.…”

Section: Introductionmentioning

confidence: 99%

Reversed phase ion-pairing HPLC-ICP-MS for analysis of organophosphorus chemical warfare agent degradation products

Richardson

Sadi

Caruso

2006

J. Anal. At. Spectrom.

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“…Several papers have been published on the analysis of chemical warfare agent degradation products using either gas chromatography/mass spectrometry (GC/MS) or high-performance liquid chromatography (HPLC) with fluorescence detection. − The limitations of the methods used in these studies include the following: insufficient sensitivity, interference from naturally occurring components in the matrixes, requirement for derivatization, or long analysis times. Others have reported on microcolumn liquid chromatography and CE with flame photometric detection for the determination of a series of organophosphoric and organophosphonic acids in environmental samples. , Also, ion chromatography (IC) can be used for the analysis of alkylphosphonic acids and their monoesters. − The IC separation requires gradient elution, which adds substantially to the analysis time, makes retention times less reproducible, produces more waste solvent, and requires more sophisticated instrumentation. CE has also been used as an alternative approach, as it offers short analysis times, little sample preparation other than dilution and filtration, and flexibility in formulating electrolytes to minimize matrix interference. − Also, because the required daily solvent/buffer usage is measured in milliliters as compared to liters with HPLC and IC, the portability of instrumentation dramatically improves, as well as allowing analysis of much smaller samples.…”

mentioning

confidence: 99%

Determination of Chemical Warfare Agent Degradation Products at Low-Part-per-Billion Levels in Aqueous Samples and Sub-Part-per-Million Levels in Soils Using Capillary Electrophoresis

1999

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A significant enhancement in the method detection limits is observed in the analysis of chemical warfare agent (CWA) degradation products in environmental samples by capillary electrophoresis (CE) using electrokinetic injection. The CE method uses indirect UV detection of the nonderivitized acidic analyte and a cationic surfactant, didodecyldimethylammonium hydroxide, for reversal of the electroosmotic flow. Analytes studied include the dibasic acid methylphosphonic acid (MPA) and its monoacid/monoalkyl esters, RMPA, where R = ethyl, isopropyl, and pinacolyl (2-(3,3-dimethylbutyl)). The CE method uses an attractive buffer system which is highly stable and inexpensive, and, in addition to reversing the electroosmotic flow, provides excellent separation efficiencies within a 3-min run. This CE method is also free from interference caused by carbonate, humic acids, and fluoride. Compared to pressure injection, electrokinetic injection with this CE buffer system provided substantially lower detection limits, up to 100-fold lower for samples in reagent water. However, to best realize the benefits of the electrokinetic injection enhancement for environmental samples, a prior cleanup of the sample using standard ion-exchange cartridges is necessary. This cleanup step uses sequential cartridges to remove sulfate (barium cartridge), chloride (silver cartridge), and cations (H+ cartridge). Using this approach, detection limits for these four acids were as low as 1-2 micrograms/L for water samples and 25-50 micrograms/L for aqueous leachates of soil samples (10 mL of leachate/1.5 g of soil). The utility of this method for separation of CWA degradation products by CE is discussed in terms of pressure injection versus electokinetic injection. The effects of voltage and time of injection on the separation were investigated. Results from three types of soils and four types of water (groundwater, artificial seawater, tap water, bay water) indicated that the method has potential for environmental monitoring. Quantitative CE analysis with electrokinetic injection enhancement of detection limits of these types of environmental samples requires the use of an appropriate internal standard approach. The data presented here indicate that an internal standard-based approach could be expected to give analysis results in the sub-part-per-million concentration range of 90-110% of the true value.

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Analysis of alkyl methylphosphonic acids in aqueous matrices by ion-pair reversed-phase ion chromatography

Cited by 51 publications

References 2 publications

Remedial investigation sampling and analysis plan for J-Field, Aberdeen Proving Ground, Maryland: Volume 2, Quality Assurance Project Plan

Remedial investigation sampling and analysis plan for J-Field, Aberdeen Proving Ground, Maryland: Volume 2, Quality Assurance Project Plan

Reversed phase ion-pairing HPLC-ICP-MS for analysis of organophosphorus chemical warfare agent degradation products

Determination of Chemical Warfare Agent Degradation Products at Low-Part-per-Billion Levels in Aqueous Samples and Sub-Part-per-Million Levels in Soils Using Capillary Electrophoresis

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