Analysis of aggregation profile of glucagon using SEC-HPLC and FFF-MALS methods
Zhongli Bao,
Ya-Chi Cheng,
Mary Ziping Luo
et al.
Abstract:Recently, the first generic glucagon for injection was approved for the treatment of severe hypoglycemia. Unlike its brand name recombinant glucagon, the generic glucagon is synthetic. Since glucagon has a high propensity to form aggregates in solution, it is essential to assess the aggregation profile of the synthetic glucagon compared to the recombinant glucagon. In this study, two robust separation methods, size-exclusion chromatography (SEC-HPLC) and field-flow fractionation coupled with a multi-angle ligh… Show more
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