Analysis of age-related changes in the left ventricular myocardium with multiphoton microscopy
Juan M. Bueno,
Rosa M. Martínez-Ojeda,
María Pérez-Zabalza
et al.
Abstract:Aging induces cardiac remodeling, resulting in an increase in the risk of suffering heart diseases, including heart failure. Collagen deposition increases with age and, together with sarcomeric changes in cardiomyocytes, may lead to ventricular stiffness. Multiphoton (MP) microscopy is a useful technique to visualize and detect variations in cardiac structures in a label free fashion. Here, we propose a method based on MP imaging (both two-photon excitation fluorescence (TPEF) and second harmonic generation (S… Show more
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